CLU_ASPFU
ID CLU_ASPFU Reviewed; 1310 AA.
AC Q4WXV2;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu1 {ECO:0000255|HAMAP-Rule:MF_03013}; Synonyms=tif31;
GN ORFNames=AFUA_3G10800;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; AAHF01000002; EAL92501.1; -; Genomic_DNA.
DR RefSeq; XP_754539.1; XM_749446.1.
DR AlphaFoldDB; Q4WXV2; -.
DR SMR; Q4WXV2; -.
DR STRING; 746128.CADAFUBP00003755; -.
DR EnsemblFungi; EAL92501; EAL92501; AFUA_3G10800.
DR GeneID; 3512080; -.
DR KEGG; afm:AFUA_3G10800; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR InParanoid; Q4WXV2; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1310
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366394"
FT DOMAIN 375..619
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1033..1066
FT /note="TPR 1"
FT REPEAT 1075..1108
FT /note="TPR 2"
FT REPEAT 1117..1150
FT /note="TPR 3"
FT REGION 662..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1245..1266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..959
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1310 AA; 145979 MW; 420DF201189665F3 CRC64;
MAIWSTRKVG LDNLRISQLL NFRGFDPSAL VTKLTDPFSL QRLLTLNQSR SPPMVNRLKD
SRKRRAAVVC RIRDTRDGWF SSLSSLTSSV IGLFQISVKL PHEPYKIQVM VSSQEQVQDV
RQSIVELPST FQYTCFHLEF NGKRINDFVE LSEVEGLKAD SEIVLVEDPY TEKEARMHVV
RFRDLVGAAG DRSDNLHGLN AGLSLHDAVT AEAATDDVKE HSLSKYDIAA SPSLETILPR
AEAPLPKTVK SISLSAWNPP PYHLRQKGHL LYLQVTTNEG EQFQITSHVS GFYVNKCSNH
KFDPLPRTTP KKVSAHSLLT LISKLSPSFN SAFEALQESN NKKDLLTTFP FQNAIPNSPW
LVTPPSSNPN SHQADITRSQ ESYLVSGVDN AETLRDWNEE FQTTRELPRE TVQDRVFRER
LTSKLFADYN EAAARGAVLV ARGEVAPLNP TEERDAQIFV YNNIFYSFGA DGVGTFVSEG
GDEAARVAVG KDVLGIKAVN QLDINGLFTP GTVVVDYLGK RIVGQSIVPG IFKQREPGEH
QIDYGGVEGK DVVATHPDFV SVFEKMSKAL RIKKHPVWDK EGKRHDLEGS VETKGLLGTD
GRKYVLDLYR VTPLDVVWQE EPGSEDYPHR MSVLRLELVE AYWRSKMSQY VKAEVERRRA
AKAQEDAANK EQPSETTESK EGESEEKAEE ALDQERVDIS GFQLALNPDV CSGQVPQTEE
EKKQWAEDEK EVRDACEFLR SKVIPELIQD LHDGDVGFPM DGRSLSQLLH KRGINIRYLG
KLAQLSKEKG SRLEALTTLL VQEMIARAFK HIANRYLRNV PAPFVASCVA HLLNCLLGAD
VNPKPSAEID ASLREIYPEG DFSFEKVTPE TLRAEVEKQV TVRYRYTLET EWFSSLRHLQ
LLRDIAIKLG LQLGARDYAF TKAQLPAKVP VANGVNGASH DESKKKKKKG GDSKSPSRAV
VEEKPVVSIV PDDIVNVVPL VKDASPRSSL AEEALEAGRI SLMQNQKQLG QELILESLSL
HEQIYGILHP EVAKLYHQLS MLYYQTDEKE AAVELARKAV IVTERTLGVD SADTILAYLN
LSLFEHASGN TKTALVYIKH AMDLWKIIYG SNHPDSITTM NNAAVMLQHL KQYSDSRKWF
EASLAVCESL FGKQSINTAT ILFQLAQALA LDQDSKGAVG KMRDAYNIFL NQLGPNDRNT
KEAETWLEQL TQNAVSIAKH AKDIQARRLR RINMNPRVTT LGTKVQPQVG QTAPEASGAK
GAANASMDSR SIDELLKFIE GGDATSSRSK QKKRAAASNP KLRGSKKSSA
