CLU_ASPNC
ID CLU_ASPNC Reviewed; 1249 AA.
AC A2QDB9;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu1 {ECO:0000255|HAMAP-Rule:MF_03013}; Synonyms=tif31;
GN ORFNames=An02g06530;
OS Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; AM270014; CAL00651.1; -; Genomic_DNA.
DR RefSeq; XP_001399789.1; XM_001399752.2.
DR AlphaFoldDB; A2QDB9; -.
DR SMR; A2QDB9; -.
DR PaxDb; A2QDB9; -.
DR PRIDE; A2QDB9; -.
DR EnsemblFungi; CAL00651; CAL00651; An02g06530.
DR GeneID; 4979144; -.
DR KEGG; ang:ANI_1_892024; -.
DR VEuPathDB; FungiDB:An02g06530; -.
DR HOGENOM; CLU_003256_2_0_1; -.
DR Proteomes; UP000006706; Chromosome 4R.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR GO; GO:0051640; P:organelle localization; IEA:UniProt.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1249
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366396"
FT DOMAIN 318..562
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 974..1007
FT /note="TPR 1"
FT REPEAT 1016..1049
FT /note="TPR 2"
FT REPEAT 1058..1091
FT /note="TPR 3"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..900
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1249 AA; 138709 MW; 1E16790EE4A263DD CRC64;
MAQTNGELEH SKETPEQLTN GNHPEETQEE DNTGGLFQIT VKLPHEPYKI QVMVSSQEQV
QDVRQSIVEL PSTFQYTCFH LEFNGQRIND FVELSEVPDL KADSEITLVE DPYNEKEARM
HVVRMRELVG AAGDRVDNLH GISAGLSLHD AISAEVADAS EKEHSLSKYD ITSSPSLKTI
LPRAEAPLPK TVKAISLSPW NPVPYHLRQK GHLLYLQVTT NEGEQFQITS HISGFYVNKN
SNMKFDPSPK TIPKSGRAHS LLTLIAHLSP SFNASFEALQ ESNNKKDLLT TFPFQNAIPN
NPWLVPPPTS TANAHQPDIT RSQENYLISG VDNAETLRDW NEEFQTTREL PRETVQDRVF
RERLTSKLFA DYNEAAARGA VLVARGEVAP LNPTESRDAQ IFVYNNIFYS FGADGVGTFA
SEGGDEAARV AVGKDVVGIK AVNQLDINGL FTPGTVVVDY LGKRIVGQSI VPGIFKQREP
GEHQIDYGGV EGKDVVATHP DFVSVFEKMS KALRVKKHAV WDKEGQRHEL EGSVETKGLL
GTDGRKYVLD LYRVTPLDVM WQEEEGSDAY PHRMSVLRLE LVESYWRHKM SQYVKAEVER
RRSAKAEADA AKAESSEATE SKEQASEEKS EEDQERVDIS GFSLALNPDV CSGQVPQTDE
EKEQWAQDEK EVRETCDYLR SKIMPELIQD LHDGDVGFPM DGQSLSQLLH KRGINIRYLG
KLAQLSKEKG SRLDALSTLL VQEMIARAFK HIANEYLRNV PAPFVASCIS HLLNCLLGAD
VNPNPVAEID ASLRSIYPEG DFSFEKATPA TLRAAIEKQV TIRYRFTLEA EWFNSLRHLQ
LLRDLSIKLG LQLGAREFIF DKSQIPAKAP ATNGANGVAQ EEGKNKKKKK GGDSSSPARA
AKEEKPILAI VPDDILNIVP LVKDASPRSS LAEEALEAGR ISLMQNQKQL GQELILESLS
LHEQIYGILH PEVAKLYHQL SMLYYQTDEK EAAVELARKA VIVTERTLGV DSADTILSYL
NLSLFEHASG NTKTALAYIK HAMDLWKIIY GANHPDSITT MNNAAVMLQH LKQYSDSRKW
FEASLEVCES LFGRQSINTA TILFQLAQAL ALDQDSKGAV GKMRDAYNIF LSQLGPNDRN
TKEAETWLEQ LTQNAVSIAK HAKDIQARRL RRVNMNPRSL GTKIQPQVGQ TAPEVAGARA
PGSASLDSRS VDELLKFIEG GDAGSSKAKQ KKRAAASNPK LRGSKKSSA
