CLU_ASPOR
ID CLU_ASPOR Reviewed; 1249 AA.
AC Q2UKX8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu1 {ECO:0000255|HAMAP-Rule:MF_03013}; Synonyms=tif31;
GN ORFNames=AO090003000629;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; AP007155; BAE57787.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2UKX8; -.
DR SMR; Q2UKX8; -.
DR STRING; 510516.Q2UKX8; -.
DR PRIDE; Q2UKX8; -.
DR EnsemblFungi; BAE57787; BAE57787; AO090003000629.
DR HOGENOM; CLU_003256_2_0_1; -.
DR OMA; VSGFYVN; -.
DR Proteomes; UP000006564; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR GO; GO:0051640; P:organelle localization; IEA:UniProt.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1249
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366397"
FT DOMAIN 321..565
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 975..1008
FT /note="TPR 1"
FT REPEAT 1017..1050
FT /note="TPR 2"
FT REPEAT 1059..1092
FT /note="TPR 3"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1178..1208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1249 AA; 138805 MW; 98434E1A984CB49F CRC64;
MAQTNGELEH SKAETPEQLT NGNHPEETQE EEQNGGLFQI SVKLPHEPYK IQVMVSSQEQ
VQDVRQSIVE LPSTFQYTCF HLEFNGKRIN DFVELSEVPD LKADSEIVLV EDPYTEKESR
MHVIRMRELV GAAGDRVDNL QGISAGLSLH DSISEEAAAG ETTEKEHSLS KYDIAGSPSL
NTILPKAEAP LPKTVKSISL SPWNPVPYHL RQKGHLLYLQ VTTNEGEQFQ ITSHVSGFFV
NKCSNARFDP FPKPMPKKGS AHSLLTLISH LSPSFTTSFE ALQEANNKKD LLTTFPFQNA
IPNSPWLVAP PSSSVNAHQP DITRSQENYL ISGVDNAETL RDWNEEFQTT RELPRDTVQD
RVFRERLTSK LFADYNEAAA RGAVLVAKGE VAPLNPTEDR DAQIFVYNNI FYSFGADGVG
TFASEGGDEA ARVAVGKDVV GIKAVNQLDI NGLFTPGTVV VDYLGKRIVG QSIVPGIFKQ
REPGEHQIDY GGVEGKDVVA THPDFVPVFE KLSKALRIKK HAVWDKDGKR HDLEGSVETK
GLLGTDGRKY VLDLYRVTPL DVMWQEEEGS DAYPHNMSVL RLELVESYWR HKMSQYVKAE
VERRRAAKAV ETASKEKSEE NAESKEEGSE EKSEEALDQE RVDISGFSLA LNPDVCSGQI
PQTDEEKEQW AQDEKEVRET CDFLRSKVMP ELIQDLHDGD VGFPMDGQSL SQLLHKRGIN
IRYLGKLAQM SKEKGARLDA LTLLLVQEMI ARAFKHIANS YLRNVAAPFT ASCIAHLLNC
LLGADVNSNP QADIDASLRE IYPEADFSFE KVTPTTLRAE IEKHVSTRYR YTPEPEWFNS
LRHLQLLRDI SIKLGLQLSA REYAFAKSQL PAKVPATNGA SQEEGKKKKK KGGDSKSPAR
AASPEKPAVS IVPDDIVNIV PLVKDASPRS SLAEEALEAG RISLMQNQKQ LGQELILESL
SLHEQIYGIL HPEVAKLYHQ LSMLYYQTDE KEAAVELARK AVIVTERTLG VDSADTILSY
LNLSLFEHAS GNTKTALVYI KHAMDLWKII YGPNHPDSIT TMNNAAVMLQ HLKQYSDSRK
WFEASLTVCE SLFGRQSINT ATILFQLAQA LALDQDSKGA VGKMRDAYNI FLSQLGPEDR
NTKEAETWLE QLTQNAVSIA KHAKDIQARR LRRINMNTRT LGTKVQPQVG QSAPSASGAS
SANPSLDSRS IDELLKFIEG GDTSSSRTKQ KKRAAASNPK LRGSKKSSA
