CLU_ASPTN
ID CLU_ASPTN Reviewed; 1274 AA.
AC Q0CNX5;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu1 {ECO:0000255|HAMAP-Rule:MF_03013}; Synonyms=tif31;
GN ORFNames=ATEG_04609;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH476599; EAU35056.1; -; Genomic_DNA.
DR RefSeq; XP_001213787.1; XM_001213787.1.
DR AlphaFoldDB; Q0CNX5; -.
DR SMR; Q0CNX5; -.
DR STRING; 341663.Q0CNX5; -.
DR PRIDE; Q0CNX5; -.
DR EnsemblFungi; EAU35056; EAU35056; ATEG_04609.
DR GeneID; 4320025; -.
DR VEuPathDB; FungiDB:ATEG_04609; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR GO; GO:0051640; P:organelle localization; IEA:UniProt.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1274
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366398"
FT REPEAT 293..326
FT /note="TPR 1"
FT DOMAIN 342..586
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 510..543
FT /note="TPR 2"
FT REPEAT 628..661
FT /note="TPR 3"
FT REPEAT 998..1031
FT /note="TPR 4"
FT REPEAT 1040..1073
FT /note="TPR 5"
FT REPEAT 1082..1115
FT /note="TPR 6"
FT REPEAT 1124..1157
FT /note="TPR 7"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..918
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1274 AA; 141353 MW; 379E87DA636D281D CRC64;
MAQTNGELEH SKGMSSPAVR ISQAQKSTKL TVDPESPEQV ANGTHAEGEQ PEENAGGLFQ
ISVKLPHEPY KIQVMVSSQE QVQDVRQSIV ELPSTFQYTC FHLEFNGKRI NDFVELSEVP
DLKADSEIVL VEDPYTEKEA RMHVVRMREL VGAAGDRVDN IQGVNAGLSL HDAIAAEAAA
GEASEKEHSL SKYEIAGSSS LKTILPRPET PLPKTVKSIA LSPWNPAPYH LRQKGHLLYL
QVTTNEGEQF QITSHVSGFY VNKCSNAKFD PFPKTIPKKR SAHSLLTLIS QLSPSFNSSF
EALQEANNQK DLLTTFPFQN AIPNNPWLVP APSSNVNAHQ PDITRSQENY LISGVDNAET
LRDWNEEFQT TRELPRETVQ DRVFRERLTS KLFADYNEAA ARGAVLVARG EVAPLNPTEE
RDAQIFVYNN IFYSFGADGV GTFASEGGDE AARVAVGKDV LGIKAVNQLD INGLFTPGTI
VVDYLGKRIV GQSIVPGIFK QREPGENQID YGGVEGKDVV ATHPDFVPVF EKLSKALRIK
KHPVWDKEGK RHDLEGSVET KGLLGTDGRK YVLDLYRVTP LDVMWQEEEG SDVYPHRMSI
LRLELVESYW RHKMSQYVKA EVERRRVAKE AAKKEQSETA EPKEEGAEEK SEEALDQERV
DISGFSLALN PDVCSGQVPQ TAEEKEQWAQ DEKEVRDTCD FLRSKVMPEL VQDLHDGDVG
FPMDGQSLSQ LLHKRGINIR YLGKLAQMSK EKGARLDALT TLLVQEMIAR AFKHIANNYL
RNVPAPFVAS CLAHLLNCLL GADVNANPRA EIDSSLREVY PEGDFSFEKA TPASLRADIE
KQVTIRYRFS LDAEWYNSLR HLQLLRDIAI KLGIQLGARD FVFAKADLPK TPVSNGVNGA
GHDDSNSNKK KKKKGGDSNS PARAAVEDKP ALSIVVDDIV NVVPLVKDAS PRSSLAEEAL
EAGRISLMQN QKQLGQELIL ESLSLHEQIY GILHPEVAKL YHQLSMLYYQ TDEKEAAVEL
ARKAVIVTER TLGVDSADTI LSYLNLSLFE HASGNTKTAL VYIKHAMDLW KIIYGPNHPD
SITTMNNAAV MLQHLKQYSD SRKWFEASLV VCESLFGRQS INTATILFQL AQALALDQDS
KGAVGKMRDA YNIFLQQLGP NDRNTKEAET WLEQLTQNAV SIAKHAKDIQ ARRLRRINMT
PRTLGTRVQP QVGQTAPESA GAKDASNTSL DSRSIDELLK FIEGGDTTSA SRSKQKKRAA
ASNPKLRGSK KSSA
