CLU_BOTFB
ID CLU_BOTFB Reviewed; 1306 AA.
AC A6SFG0;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu1 {ECO:0000255|HAMAP-Rule:MF_03013}; Synonyms=tif31;
GN ORFNames=BC1G_11770;
OS Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis
OS cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=332648;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B05.10;
RX PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH476926; EDN32665.1; -; Genomic_DNA.
DR RefSeq; XP_001550012.1; XM_001549962.1.
DR AlphaFoldDB; A6SFG0; -.
DR SMR; A6SFG0; -.
DR GeneID; 5430505; -.
DR KEGG; bfu:BCIN_10g03630; -.
DR OMA; VSGFYVN; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR GO; GO:0051640; P:organelle localization; IEA:UniProt.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Repeat; TPR repeat.
FT CHAIN 1..1306
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366399"
FT DOMAIN 336..580
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1032..1065
FT /note="TPR 1"
FT REPEAT 1074..1107
FT /note="TPR 2"
FT REPEAT 1116..1149
FT /note="TPR 3"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1275..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1306 AA; 143626 MW; EA8FAED7FDC1528F CRC64;
MAVNNEVNNA ASETPTDVSS SSQKLATEET ALTNGADHEE EDGGEAGGEV FQLTVVLPRE
PHKIQIIVSS QEAIHDVRQS IIELPGTFQY SCFHLEHKGE RINDFVQISE VPGLTADSEI
HLVEDPYTEK EARIHIIRVR ELIGAAGDRT DTLNGIISGA SLLDSVTSKE SSQNGTSTAP
SHPMVGFDFQ GSGNLSTLLP RAQEPGPKTV KSISVSPWNP PPYHLRQKGH LLYLQVTTNE
GEQFQITSHV SGFYVNKSST GKFDPSPKSA PKAHSAHSLL ALLSDLSPSF EESFKGLQEY
NNAKEPLATF QITNATPSNP WIVPSATAPL VAHQADITRT QENYLIAGIE NSETLRDWNE
EFQSTRELPK DTVQDRVFRE RLTSKLFADY NDAAARGAIL VARGEIAPLN PTEGKDAQIF
VYNNVFFSFG ADGVGTFASE GGDEAARAAV GKDVMGVRMV NQLDIDGLFT PGTVVVDYLG
KRIVGQSIVP GIFKQRDPGE NQIDYGAVDG KDIVASDEKF VSVFEKLSKA LKVKKHAVWD
KDAKRHDLEG SIETKGLLGT DGRKYVLDLY RVTPLDITWM EEVGTALDSP KEADAASESA
YPHRMTVIRP ELVEAYWKVK MREWVNGELE RKRQAQKAVE PAAEGKEIEA ATEASEPAKS
EEPPENGELA KKSESDEAAE PSKPDQERID IGDFKFALNP DAFSGQQPQT DEEKTEFAED
EQQVRLVCEF LRKTVLPELV KDLKEGDVGF PMDGQSLSRL LHKRGINLRY LGQVATLADG
KRLESLRILA VQEMVSRAFK HVAGNYLRYL PIPLTSSCIA HLLNCLLGTD LNAAPKPDVD
EAIAALYPEA DLKFKEVTPE SLKQEIEGQV LRRFRYTLDS TWTAGIKHLQ LLREVSLKLG
IQLEMKPYHF TKQSQTESAA APPATNGEAT KEAAPTGKST NGKKKKKNAR EASPAAVVSA
NAASPVTFNP DDILNTVPVI KEASPRSSLA EEALEAGRIS LLQDQKKLGQ ELLLESLSLH
EQIYGILHPE VARVYNSLSM LYYQLDEKEA AMELARKAVI VSERTLGVDN AETLLNYLNL
GLIAHASGET KLALTYIKHA LDLWKVVYGP NHPDSITTIN NAAVMLQHLK EYHDSRTWFE
ASLKICEEVY GKHSINAATL LFQLAQALAL DQDSKSAVNR MRESYNIFLT ELGAEDKNTK
EAEKWLEQLT QNAVSIAKHA KDVQARRNRG IRVSPRVTLG QTQVQPQIGQ TVEAAAGRDT
PRGLDSRSID ELLKFIEGSD QSNQNKKRPG RSNPKRRGGA AATAGK
