CLU_BRUMA
ID CLU_BRUMA Reviewed; 1453 AA.
AC A8PJX4;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN ORFNames=Bm1_28595;
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDP33970.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DS239371; EDP33970.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001897167.1; XM_001897132.1.
DR AlphaFoldDB; A8PJX4; -.
DR SMR; A8PJX4; -.
DR STRING; 6279.A8PJX4; -.
DR GeneID; 6100617; -.
DR CTD; 6100617; -.
DR WormBase; Bm4445; BM40048; WBGene00224706; Bma-clu-1.
DR InParanoid; A8PJX4; -.
DR OrthoDB; 60958at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1453
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366389"
FT DOMAIN 439..690
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1235..1268
FT /note="TPR 1"
FT REPEAT 1277..1310
FT /note="TPR 2"
FT REGION 78..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1453 AA; 163098 MW; 58B2380A5E7068D9 CRC64;
MCVCACARVC VYVCTRHHPP LDVFPADDVI TPPCSSWPLR GVMSRPACQC LRRCEVMGEV
NGPVCSPEIV LASAGKTLSE NGQENSPHNS DSGHETSSPD SPLTPIEEGA VSPGDDSFFV
VWIKFMVLPR KLCINKDVEK LFSAAEKTGN DGEVLCPSDE CDTFRIRIIA PGAEPFDLQV
NSNEMVQELH QVLLEREATC HRTCFSLQLN GVSLDHFTEL KNISGLTDGS VLRVVEQPYT
TREARIHVRH IRDLIRSLDM SDAVNGTDGA SMSYLASMTL GDRKKNADKT LECSPPDYVL
PGYKERPLIP LLPVMKEPVL ALKSLAISPF NPPPGHRKLK GDVLYLTFDT REGRRYHITC
CTKGFYVNAT TEAGFRPTPS PSHRTVHHSL LDLLSSISIS FKRAMALILK RRSEKHIFER
LPTPYQVNSW IAPVFEQIED GIRAEDCTQP HKIGLEDHIP GQIRDWNEEL QTTHELPRET
LGERLIRERA IFKIHSDFVS AAIKVNVSMA VVDGNVVAIN PADEPRTHMY IWNNIFFSLG
FDVKDHYKDL GGDAAAHAAT SNDLQGVRAY AQLDNPKLFT LGMVIVDYKG FRVTAQSIIP
GILEREQEQS VIYGSVDFGK TVVSSEEYHD LLSKPAEQLK ILPHEVHSGK DDGKIIKLCS
SFETKGIVGN DSRHYILDLL RTFPPDVNYL EDAEVTDICK ANGYPRTFPH KLASLRQELI
DAFVEYRYLM FIRIAAYHVQ QTKLGLLETD YNDDKKETTK EDTVLKVTGF SEDAIMSQIK
REITADIKID EMPLLETEAA KKIMEEVIDS DHKKVDSLDK EISETIMAKA AKAVGSIRMD
AFDVRFNPDC YCSTVRHAES EDITKQRRLV AEAAEFLIVQ QLPNFVRDCL QRTIMLLDGA
SLIDSLHSRG INIRYLGKLT KYIQNVGQLS YVKVICITEL LCRCAKHIFR GYLQPVSSAH
TAAAVSHFLN CLLSSSTEPL TPSNEEVSMP INSVKKSRSS KRRKQISSGG KENDDWAQMS
SHKLWERVKS DADFYYAFTI DEENIDAYLS TVGIQKTSFL RRFVQIVGIQ MLLRDYNLES
GKKSQLFVED DIQSLYCQAK HVDPKAVDAH SLFLSGQTKV QQGQLRAGFD LVLESLNLMN
SVYGAMHSDM AQCMRLLARL SYILGDPSEA LSQQHKATLM SERCNGLDSA NTIIEYLNLA
HFSFANLHIA AALKLLYRAR YLLLLIHGEN HPFMAEIDGN IGVILYAVQE FDDALKFLQN
ALKLHQIYLE PQALKTALIY HLLARTYSCR GDFRTALQME KETFTIYSKT FGIDHEKTKE
SSDCLKHLTQ QAVTFQKRIN EANRQGSNNI GQLLPVEIHR PSLHSVLEVL NILNGIIFIQ
LKGISTSSDI GEENYELGNN NNNNNKRKKK AVEDLAVKKN GNNDDTTVIS SRPQVNNMSG
SSTVQVMQEV ALD
