ID   CLU_CAEBR               Reviewed;        1262 AA.
AC   A8XAA9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=clu-1 {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=CBG10067;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; HE601459; CAP29577.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8XAA9; -.
DR   STRING; 6238.CBG10067; -.
DR   WormBase; CBG10067; CBP02460; WBGene00031546; Cbr-clu-1.
DR   eggNOG; KOG1839; Eukaryota.
DR   HOGENOM; CLU_003256_1_0_1; -.
DR   InParanoid; A8XAA9; -.
DR   OMA; VSGFYVN; -.
DR   OrthoDB; 60958at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 2.
DR   Gene3D; 3.30.2280.10; -; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR007967; GSKIP_dom.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF05303; DUF727; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS51823; CLU; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..1262
FT                   /note="Clustered mitochondria protein homolog"
FT                   /id="PRO_0000366390"
FT   DOMAIN          335..580
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1262 AA;  141688 MW;  D156A2249C1B5247 CRC64;
     MTSGSELKAE VDAPVVNGKD ELVHEEDNND SGHSSINTPD ASEDKQTDKL VKVTIQPSCG
     EAFDLHLSDN ELVQELYQTL LDREATCHRT CFSLYLNGTA VDNYSEVRSV PGFIDGCTLN
     VVDEPYTVRD ARLHLRQVRE LLRFGLVQDQ HEPPCGNEAQ SYLASIDLNP SEKKESKQSD
     ILPPDYVLPG CKERSLAHLV VPQQKELIAV KDIAFSPFNP PPGPRKLRGD VLYIDVTTVE
     NRVYHLTCCT RGFYVNNSQE QKFDPTISNA NKTIYQSVIE LLQNVSPGFK KVYPQILKRR
     VEKSLVERLP TSYPVSTWVA SPLKPDNYSS DSLRAIELIE PFRVGFEDHM PGLLRDWNEE
     LQTTFEMPRK SLAERAVRDR SYYKIHADYV NAAAKGVQSI LDGNILAINP GEDKKTHMYI
     WNNIFFSLGF DVRDHYKELG GDAAAFAATS TDLQGVRAFA TLEDPKLNTL GMAIFDYRGY
     RVTAQSIIPG ILEREQEQSV VYGSIDFGKT VVSDEKYHAL LEDAAQQLKM LPHNVISVKD
     GVEQELKLFT SYEAKGIVGN DGRKYVLDLL RSMPPDVHYL EDAEVSETAK DLGYPRKFPH
     KLSALRRELV DQFCESRLVM FIQSTARKIR ALITEAKEKN DEELIKQAAE AESELSLVFV
     AVSEDREIET KNKIVQDAIK EACAEIHSIY EDRFVIKFNP DCFSPNVKHA PSENLERQRR
     VVIDAAEYLL TNQIPEIVQS FKDCTVQPID GNNLADILHS KGINIRYLGE IGKRVQDTNS
     FARPLVLSDI VARSAKHVIR KINVQTPVDQ LVVSTSHILN CLFSTVSEPS PVASHAHKKS
     SKKNGKKKNS GVWATLTTAS LWKSICEESA YYYGYHIDTE TLDKFLEQHE IQKTALFRRV
     VKIMGVQIVA RDYQLDSSAK KVAAFTEDDI INFYPIIKHH QPFTVDAKKM IIRGQHAMSL
     GASREAYECI SEAINIMTAV YGVMHPDMPQ CLRALARLGH VLGETPDALN HQHKATVMSE
     RLIGLDSGNT IIEYNSLIHY LLICFQINLA HFAFGALLIP GSLRPLYRAR YLMNLVFGEK
     HPIMAQIDAN IGTILFTIQE YDTALKYLQS ADAISKAIGE PRKLKTGLIS NLIARTHAAR
     GDFRAALVAE KETSSIYTEL YGKNHQRVKD SGEYLRTLTQ QAVTFQKKML NPDNNTNINE
     LFQIQPPPIS ALFDILNIIN GIMIIGIPGL SNLAALEKEQ IGTAEESKAT DVAAQLDNET
     LD