CLU_CAEEL
ID CLU_CAEEL Reviewed; 1247 AA.
AC P34466;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu-1 {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=F55H2.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; Z27080; CAA81605.1; -; Genomic_DNA.
DR EMBL; Z22176; CAA81605.1; JOINED; Genomic_DNA.
DR PIR; E88557; E88557.
DR PIR; S40989; S40989.
DR RefSeq; NP_499097.1; NM_066696.5.
DR AlphaFoldDB; P34466; -.
DR SMR; P34466; -.
DR BioGRID; 41537; 5.
DR STRING; 6239.F55H2.6; -.
DR EPD; P34466; -.
DR PaxDb; P34466; -.
DR PeptideAtlas; P34466; -.
DR EnsemblMetazoa; F55H2.6.1; F55H2.6.1; WBGene00000550.
DR GeneID; 176341; -.
DR KEGG; cel:CELE_F55H2.6; -.
DR UCSC; F55H2.6.1; c. elegans.
DR CTD; 176341; -.
DR WormBase; F55H2.6; CE00213; WBGene00000550; clu-1.
DR eggNOG; KOG1839; Eukaryota.
DR GeneTree; ENSGT00390000012485; -.
DR HOGENOM; CLU_003256_1_0_1; -.
DR InParanoid; P34466; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR PhylomeDB; P34466; -.
DR PRO; PR:P34466; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000550; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..1247
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000123554"
FT DOMAIN 329..579
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1222..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1247 AA; 139921 MW; CF44F3EF27D8774F CRC64;
MTLGSETKTD VEVPIINGKH EIPQEENDSG HSSINTPDSS EPDKQVDKFV KITIQPSCGD
AFELHLSDNE LVQELYQTLL DREATCHRTC FSLYLNGTAV DNYSEVRAIP GFVDGCTLNV
VDEPYTIRDA RLHLRQVREL LKFGLTEDQH EPPCTNDAQS YLTTINLQPE EKKEPKPSDI
LPPDHALPGC KERSLAHLLV PQPKELIALK DIAFSPYNPP PGPRKLRGDV LYIDITTVEN
RIYHVTCCTR GFYVNNSQDG RFDPTVSNSN KTVYQSVIEL LQNVSPGFKK VYPQILKRRQ
EKTLVERLPT SYPVSSWVGN PLKTDGYMSD SLRAIELTEP FRVGFEDHMP GLLRDWNEEL
QTTFEMTRKS ISERVIRDRS YYKIHADYVN AAARGVQSIL DGNILAINPG EDKKTHMYIW
NNIFFSLGFD VRDHYKELGG DAAAFAATST DLQGVRAFAT LDDPKLNTLG MAIFDYRGYR
VTAQSIIPGI LEREQEQSVV YGSIDFGKTV VSDEKYHELL EDAAHKLKML PHTVISEKDG
VKEELKLYTS YEAKGIIGND GRKYVLDLLR SMPPDVHYLD DAEVSEAAKT LGYPRKFPHK
LSALRRELID AFCESRLVTF IQLTAKKIRD LITESKEKND ETLIKQAAEA ETELSLLFMA
ISEDKEFEAK NKVVQDAIKE ACAVVHSIYE DRYVMKFNPD CFSSNVKHAP TENLERQRRV
VVDAADFLLT QKIPELVQNL KDCVVQPIDG DNLADIMHIN GINIRYLGEI GKRLENSVSF
ARPLVLSDIV ARSAKHVIRK INVQITADQL SASTSHILNC LFSVVLDPSP IAANVAKKAN
KKNGKKRVTS AWSSLTTSAL WNSIREDSAS YYGYPIEADS LEKFTELHDI QKTALFRRIC
KVMGVQLVAR DYQLDNSTAK KTSIFVEDDI INFFPIIKHH EPFTADAKKM FIRGQQAMSI
GASREAYECI GESLNLMTLV YGVMHPDMPQ CLRALARLSH VLGETGDALN NQHKAAVMSE
RLIGLDAGNT IIEYINLAHF AFGALLIPGS LRPLYRARYL MNLVFGEKHP VMAQIDANIG
LILFTVQEFD TALKYLQSAD AITKTIGEPR KLKTGLISNL IARTHAARGD FRAALVAEKE
TFAIYSELYG PNHPRVNESS EYLRTLTQQA VTFQKKMLKL DNSTNITELF QAQPPTVTSL
FDTLNIINGI LIIGVPGLSS LGKQQNGTTE ESKTTDVAAQ LDNETLD
