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CLU_CANAL
ID   CLU_CANAL               Reviewed;        1363 AA.
AC   Q59MA9; A0A1D8PDF8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE   AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013};
GN   OrderedLocusNames=CAALFM_C104970WA; ORFNames=CaO19.51, CaO19.7712;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC       factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; CP017623; AOW26169.1; -; Genomic_DNA.
DR   RefSeq; XP_710862.2; XM_705770.2.
DR   AlphaFoldDB; Q59MA9; -.
DR   SMR; Q59MA9; -.
DR   BioGRID; 1230621; 1.
DR   STRING; 237561.Q59MA9; -.
DR   PRIDE; Q59MA9; -.
DR   GeneID; 3647528; -.
DR   KEGG; cal:CAALFM_C104970WA; -.
DR   CGD; CAL0000196200; orf19.7712.
DR   VEuPathDB; FungiDB:C1_04970W_A; -.
DR   eggNOG; KOG1839; Eukaryota.
DR   HOGENOM; CLU_003256_2_0_1; -.
DR   InParanoid; Q59MA9; -.
DR   OrthoDB; 60958at2759; -.
DR   PRO; PR:Q59MA9; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 2.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS51823; CLU; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1363
FT                   /note="Clustered mitochondria protein homolog"
FT                   /id="PRO_0000366400"
FT   REPEAT          29..63
FT                   /note="TPR 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   REPEAT          120..154
FT                   /note="TPR 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   REPEAT          283..316
FT                   /note="TPR 3"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   DOMAIN          361..631
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   REPEAT          548..581
FT                   /note="TPR 4"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   REPEAT          1057..1090
FT                   /note="TPR 5"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   REPEAT          1141..1174
FT                   /note="TPR 6"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   REPEAT          1183..1216
FT                   /note="TPR 7"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   REPEAT          1225..1258
FT                   /note="TPR 8"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   REGION          172..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          799..844
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1291..1363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        799..832
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1291..1340
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1363 AA;  155834 MW;  36A066BE4FAD1497 CRC64;
     MSSEEKIEET QQQQQESVPV KELLLKVQLP SFFNVGDDYL TIPSSYEENI ADLKQALNII
     VLCRNLTNYS ILIKGIDIIE NFGELITFEQ IISHFELDKQ EEQEEQGQER EISELKIVIK
     EKSYNLASIY EQISRFREVI GLHYIDRLSN DIGSCGGVSK FNGIQLDDIK PKEAKKEEST
     EKEQQEKEEL SISKEEVSKI SDFAKQFISD SFDGNDFTKL TKFDDINGKV KIPIKSLTIS
     QWSPVPPFQQ AKGDLLYLSL QTLEHETFNI TCHFSGFFVN KSSTINFNPT IKINEKGKFN
     KSYLLYDLVC QLSPLFSKTI AENEINLSDS TKYPETYLLP GNSFPAYPWL VNEKDLQNVP
     DLSRSQLSSL INGVDGADYI KDWNNDIQSI KELPTTTVQE RIIREKLIQK SLFEFNKTAT
     ETAINIIKGN IPPLNPDESS DKFIYLRNGI FYSSGTSTVN GFENTGGEEA SRYVASKDLT
     GIKLINRHDI RGISSLVTCI VDYMGKRVVC QAPVPGILDT PVITSPTTDA EGKNEAEEPE
     SEPVEKVVYG LSSDGSRILE DKSFEEPLKQ IGDFFHLKPH KVQLSSSSSG DDVKTESNLV
     VSKDTKGLKG TDGRKYVIDL YRTTPRDIEF IEQHFKLDDD HQETSYPHGE ALIRHEAVNE
     WWRRKVAVLF KKETEQLEKE GKLLDKNQDQ DQENKPQIAI PTDQVVFNPD AFSSDNENEI
     EQDREEVREI SKFIKEKLIE EFLDEIKDQV IPFDGQQLTD VLHRSGINMR YLGYVAERLV
     VKKEKHLVDL EELIKENEAK AEKKREEEKE KEEKEATESE DKKEKKEDKE DAEKEEAEAE
     EEVPTKATYQ LTLANYSTLH RIIIQEMISR SVKHILRNLT KSLPSYLIST AIAHFHNCLF
     GGAINPTPKV DFIDEIYKNF CSKSDLESFI KLTHDDVIKL VSKEVFSRFR YKLSSNWINT
     IQLPQLFREI AFKYGIQWKS QNYPFTKEEF ELQNNQNKET PTQIQIIETK SSKKSKKKTQ
     TQVITEKSIQ RSSIFIADDI IGFIPIIKDS SYKSTIVEEI YSNARSHLVQ GNKEMGMALF
     NELLAINESI YGKVNPETAK FYNLVAQVYQ ELGYDIEAAL IGRKAVILCE RSCGFDSYDT
     ITAYMNSAYY ESSNEQYLNS LKLYKEAMNT WSLVYGKDHP TLINTLTNLS ESLLKIKAYD
     SALELLQEAL EITKKLNGEI SEITGFIYYR IANIVVTLNK FKESKELFDK AYDIFMKLLG
     PDDSMTKQVA KYVSSVGLYV EYLKRQQQQQ QQETQKKSKT KTKAAPVNNI ATTSTSTTKN
     GKKSKKNNTP PQSNPEIANQ SIDEILRFIE GKPSGSKKSN KKK
 
 
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