CLU_CANAL
ID CLU_CANAL Reviewed; 1363 AA.
AC Q59MA9; A0A1D8PDF8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013};
GN OrderedLocusNames=CAALFM_C104970WA; ORFNames=CaO19.51, CaO19.7712;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CP017623; AOW26169.1; -; Genomic_DNA.
DR RefSeq; XP_710862.2; XM_705770.2.
DR AlphaFoldDB; Q59MA9; -.
DR SMR; Q59MA9; -.
DR BioGRID; 1230621; 1.
DR STRING; 237561.Q59MA9; -.
DR PRIDE; Q59MA9; -.
DR GeneID; 3647528; -.
DR KEGG; cal:CAALFM_C104970WA; -.
DR CGD; CAL0000196200; orf19.7712.
DR VEuPathDB; FungiDB:C1_04970W_A; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR InParanoid; Q59MA9; -.
DR OrthoDB; 60958at2759; -.
DR PRO; PR:Q59MA9; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1363
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366400"
FT REPEAT 29..63
FT /note="TPR 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT REPEAT 120..154
FT /note="TPR 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT REPEAT 283..316
FT /note="TPR 3"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT DOMAIN 361..631
FT /note="Clu"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT REPEAT 548..581
FT /note="TPR 4"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT REPEAT 1057..1090
FT /note="TPR 5"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT REPEAT 1141..1174
FT /note="TPR 6"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT REPEAT 1183..1216
FT /note="TPR 7"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT REPEAT 1225..1258
FT /note="TPR 8"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT REGION 172..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..832
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1363 AA; 155834 MW; 36A066BE4FAD1497 CRC64;
MSSEEKIEET QQQQQESVPV KELLLKVQLP SFFNVGDDYL TIPSSYEENI ADLKQALNII
VLCRNLTNYS ILIKGIDIIE NFGELITFEQ IISHFELDKQ EEQEEQGQER EISELKIVIK
EKSYNLASIY EQISRFREVI GLHYIDRLSN DIGSCGGVSK FNGIQLDDIK PKEAKKEEST
EKEQQEKEEL SISKEEVSKI SDFAKQFISD SFDGNDFTKL TKFDDINGKV KIPIKSLTIS
QWSPVPPFQQ AKGDLLYLSL QTLEHETFNI TCHFSGFFVN KSSTINFNPT IKINEKGKFN
KSYLLYDLVC QLSPLFSKTI AENEINLSDS TKYPETYLLP GNSFPAYPWL VNEKDLQNVP
DLSRSQLSSL INGVDGADYI KDWNNDIQSI KELPTTTVQE RIIREKLIQK SLFEFNKTAT
ETAINIIKGN IPPLNPDESS DKFIYLRNGI FYSSGTSTVN GFENTGGEEA SRYVASKDLT
GIKLINRHDI RGISSLVTCI VDYMGKRVVC QAPVPGILDT PVITSPTTDA EGKNEAEEPE
SEPVEKVVYG LSSDGSRILE DKSFEEPLKQ IGDFFHLKPH KVQLSSSSSG DDVKTESNLV
VSKDTKGLKG TDGRKYVIDL YRTTPRDIEF IEQHFKLDDD HQETSYPHGE ALIRHEAVNE
WWRRKVAVLF KKETEQLEKE GKLLDKNQDQ DQENKPQIAI PTDQVVFNPD AFSSDNENEI
EQDREEVREI SKFIKEKLIE EFLDEIKDQV IPFDGQQLTD VLHRSGINMR YLGYVAERLV
VKKEKHLVDL EELIKENEAK AEKKREEEKE KEEKEATESE DKKEKKEDKE DAEKEEAEAE
EEVPTKATYQ LTLANYSTLH RIIIQEMISR SVKHILRNLT KSLPSYLIST AIAHFHNCLF
GGAINPTPKV DFIDEIYKNF CSKSDLESFI KLTHDDVIKL VSKEVFSRFR YKLSSNWINT
IQLPQLFREI AFKYGIQWKS QNYPFTKEEF ELQNNQNKET PTQIQIIETK SSKKSKKKTQ
TQVITEKSIQ RSSIFIADDI IGFIPIIKDS SYKSTIVEEI YSNARSHLVQ GNKEMGMALF
NELLAINESI YGKVNPETAK FYNLVAQVYQ ELGYDIEAAL IGRKAVILCE RSCGFDSYDT
ITAYMNSAYY ESSNEQYLNS LKLYKEAMNT WSLVYGKDHP TLINTLTNLS ESLLKIKAYD
SALELLQEAL EITKKLNGEI SEITGFIYYR IANIVVTLNK FKESKELFDK AYDIFMKLLG
PDDSMTKQVA KYVSSVGLYV EYLKRQQQQQ QQETQKKSKT KTKAAPVNNI ATTSTSTTKN
GKKSKKNNTP PQSNPEIANQ SIDEILRFIE GKPSGSKKSN KKK
