ID   CLU_COCIM               Reviewed;        1282 AA.
AC   Q1E101; J3KCE8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE   AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=CIMG_03762;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC       factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; GG704916; EAS32738.3; -; Genomic_DNA.
DR   RefSeq; XP_001244321.1; XM_001244320.2.
DR   AlphaFoldDB; Q1E101; -.
DR   SMR; Q1E101; -.
DR   STRING; 246410.Q1E101; -.
DR   PRIDE; Q1E101; -.
DR   EnsemblFungi; EAS32738; EAS32738; CIMG_03762.
DR   GeneID; 4563128; -.
DR   KEGG; cim:CIMG_03762; -.
DR   VEuPathDB; FungiDB:CIMG_03762; -.
DR   InParanoid; Q1E101; -.
DR   OMA; VSGFYVN; -.
DR   OrthoDB; 60958at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR   GO; GO:0051640; P:organelle localization; IEA:UniProt.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 2.
DR   Gene3D; 3.30.2280.10; -; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS51823; CLU; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1282
FT                   /note="Clustered mitochondria protein homolog"
FT                   /id="PRO_0000366402"
FT   DOMAIN          341..585
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REPEAT          1003..1036
FT                   /note="TPR"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          631..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          892..936
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1202..1282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        910..924
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1208..1227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1282 AA;  143048 MW;  39C48CCC7D6ED3F8 CRC64;
     MEQNNGTTEH PKEVLDQTNP SNEVTGVPNG NHAEGEGDQN AGEAPGLFQI TVKLPHEPYK
     IQVMVSNQEQ VQDVRQSIVE LPGTFQYTSF HLEHNGERIN DYVELSEVKD LKPDAEIVLV
     EDPYTEKEAR MHLVRIRELI GASGDRVDNL HGICAGLSLH DSVAAGEQLS DDIPSKEENS
     ANGTAEHALV GYEVPGPADL RTILPRKQAP FPKTVKSISL SPWNPPPYHL RQKGHLLYLQ
     VTTNEGEQYQ ITSHVSGFFV NKCSNSKFDP FPRAAPKNYS AHSLLTLISL ISPSFENSFK
     ALQEANNKKD LLTTFPFQNS IPHNPWLVPP TSSPATAHQS DITRPQENYL IAGVDNSETL
     RDWNEEFQTT RELPRDTVQD KVFRERLTSK LFADYNDAAA RGAVLVARGE VAPLNPTEGR
     DAQIFVYNNI FFSFGADGVG TFASEGGDEA ARVAVAKDVM GVKAVNQLDI AGLFTPGTMV
     IDYLGKRVVG QSIVPGIFKQ REPGEHQIDY GGVDGKDVIA KHEAFVPVFE KLSKALRVKK
     HPVWDKDGAR HELESSVETK GLLGTDGRKY VLDLYRITPL DVLWYEDSEN HEPYPHRMSV
     LRLELVESYW RFKMGQYVKE EVEKRRKAKK EAEEKAEESK PNGEAADASE NAESEKKETT
     SPDQERVDIS DFKLALNPDV FSGQVPQTDE EKEEWAQDEK EVRDACNYLR SKVLPELIQD
     LHDGDVGFPM DGQSLSQLLH KRGINVRYLG KLAALAKEKG ARLQALTALM TQDMVARAFK
     HIANRYLRNL PSAFATSCIA HLLNCLLGTE VNSKPRAEID ESLREIYPEG DFSFEQVTPT
     ALKEDIEKQI KIRYRFSLDA DWTSSLRHLQ LLRDISLKLG LQLGAKNYAF DRSQLKNQDH
     SPAANGTRTP EEGGKKKKKK GSDQASPRPA QSPAPAVTFV PDDILNIVPI VKDASPRSAL
     SEEALEAGRI SLMQNQKELG QELILESLSL HEQIYGILHP EVAKLYHQLS MLYYQSDDKD
     AAVELARKAV IVTERTMGVD SADAILSYLN LSLFEHATGN TKVALVYIRH ALELWKIIYG
     PNHPDSITTM NNAAVMLQHL KLYPDSRKWF EASLTVCEEL FGRQSVNTAT ILFQLAQALA
     LDQDSKAAVN RMRDAYNIFL NELGPEDRNT KEAESWLEQL TQNAVYIAKH AKDIQARRRR
     LANLPTRLGT KPQPQVGQTT SEMANAAEAR GNASLDPRSI DELLKFIEGG ESSAPRTKQK
     KRAAARNPKL RGSKQSTVKP SS