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CLU_CRYNB
ID   CLU_CRYNB               Reviewed;        1502 AA.
AC   P0CR87; Q55HY4; Q5K7G8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE   AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013};
GN   OrderedLocusNames=CNBM2330;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC       factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; AAEY01000064; EAL17429.1; -; Genomic_DNA.
DR   RefSeq; XP_772076.1; XM_766983.1.
DR   AlphaFoldDB; P0CR87; -.
DR   SMR; P0CR87; -.
DR   PRIDE; P0CR87; -.
DR   EnsemblFungi; AAW46737; AAW46737; CNM02490.
DR   EnsemblFungi; EAL17429; EAL17429; CNBM2330.
DR   GeneID; 4939595; -.
DR   KEGG; cnb:CNBM2330; -.
DR   VEuPathDB; FungiDB:CNBM2330; -.
DR   HOGENOM; CLU_003256_2_0_1; -.
DR   Proteomes; UP000001435; Chromosome 13.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 2.
DR   Gene3D; 3.30.2280.10; -; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS51823; CLU; 1.
PE   3: Inferred from homology;
KW   Cytoplasm.
FT   CHAIN           1..1502
FT                   /note="Clustered mitochondria protein homolog"
FT                   /id="PRO_0000410305"
FT   DOMAIN          399..693
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          571..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          755..799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1054..1085
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1381..1403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1429..1502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..606
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        755..778
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1054..1081
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1435..1461
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1502 AA;  164198 MW;  AEF63A266216FF3C CRC64;
     MSESAKAAAQ NGQAEEQQLQ QQLDEQQQLE EQQQLPPVTI RIPSPTCSRT VPKPKDSTEP
     LDRITLYPQP QETIQDIKLL INDWVGAYWL GPYSLQLPFV KGEDGRGKIY SKKKDFSEVR
     AGEKLNEWLE VQDAFEHLQE GEERVLEAVR EPYGELSARQ SIIRLLELIA PSGTTANTTS
     NPLGLQAGST IFEQVRDGLV SANAETTYEE VEVSLPSGRK GKGGKKELVK VKRSVSGDKA
     HAFADWKGWA PASFGSLAVS SDPVEVAPSL KSIQISHFNP PPPHLRQKGH ELYLQVSLLE
     GEVVTLICST RGWYVSKSNV NNFDPSPRPS ADGSIPAPTH SLIDLLHSIS PLFSERVSRL
     PPISLDGALA DPISTVAIPQ ATPAYPFLTS PPKPAISPEI LRTQLAFLHT GAYGPDLVDA
     ARDWNEEIQG IRELPRGTMQ ERVFREKMLQ KVWAEFDQAA ARAVQAVSKG DIPPINPAED
     PKAHMYLQSN IFITQGDSDA LDTYAHLGGD AAMRISHGKD AAGVKLLNKI DADGLYLLGH
     TIVDWQGRRW ICQSILPGIF SNRRAVEEEK AQAETEAEAE TADAVEGEQK KEDWVDVEKP
     TEKSGSETES DNPMMIYGLD SERPTSVHWD AATHSLLSTI ATPLRLAAHT IKDGEGKEHE
     FYASAEVKGL KGQDGRRYLL DAQRLAPVDV EWLEKDITGP LVGPKKDDES AEEGVQYPHR
     LVMLRPELIE QFWESELKRW ARGVAEKAQA KKAEAEAEAA AAADAEGEKK KEGEQSEIPQ
     EEQSAAASAA AARRAEEDRP VDASLIGDIK QFNLSFNPDA FVEQPVLEAE GQEGKTEIKA
     AITDESDPSV KAVRDAGLFL RQIAIPAVVL DVLTGNTSGV MDGESLSKHL HQRGVNIRYL
     GHLASTIIQF STSKDGAAKE PSGHLAALQS IVLQEMVFRA AKHILRELLY PLQPETATDA
     VSHFLNCLLG SCLNPAPVAS YTPIGINSNE PEPAYVKLTP ECLRAQIIKE VKSRFRWTLD
     ESFLESGLRK KQLLRELASR VGFQLAQREY VFSKDQEEEE NKREENIKSK EKKKGSKAGA
     KGETVKRTTT FEGEDVLTLV PVIKSTAPSV SVAEEILEAG RNTINRGKIE FGLDFMLEAI
     QLYESIHSVI HPEVASVYNS YAQAIHQIAR LKIQQIAAQE NPDPEQPLGV DISGALRFQR
     QAVAIAERTL GVYHHETAGY YFQLAMLENL EGNAQQSLRY FRHLLTLWDV IYGPGHPEIS
     TILSNAGIVL QSMNDLSLSL SLQKQAYEST LACFGPNHIQ TGQSLHQLVQ GHFLAGDMAS
     ALETAKQALE IFKARLGEEH NQTKEEAKNV ELLTAVIENQ ERQKEREEAV KKEATERLKM
     ARERIGGGAA STSRPTGIRR LGGAGAGALP QGVRVVDPQT LAALAAAAGQ GGNPSANAAA
     ATAGQGEQAN GESTGTPQIG ERGTESLEEL VRYIQGSAPG VGGSAKRGKN ALRGKRRTGA
     KR
 
 
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