CLU_CRYNB
ID CLU_CRYNB Reviewed; 1502 AA.
AC P0CR87; Q55HY4; Q5K7G8;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013};
GN OrderedLocusNames=CNBM2330;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAEY01000064; EAL17429.1; -; Genomic_DNA.
DR RefSeq; XP_772076.1; XM_766983.1.
DR AlphaFoldDB; P0CR87; -.
DR SMR; P0CR87; -.
DR PRIDE; P0CR87; -.
DR EnsemblFungi; AAW46737; AAW46737; CNM02490.
DR EnsemblFungi; EAL17429; EAL17429; CNBM2330.
DR GeneID; 4939595; -.
DR KEGG; cnb:CNBM2330; -.
DR VEuPathDB; FungiDB:CNBM2330; -.
DR HOGENOM; CLU_003256_2_0_1; -.
DR Proteomes; UP000001435; Chromosome 13.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm.
FT CHAIN 1..1502
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000410305"
FT DOMAIN 399..693
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1054..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1381..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..606
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1081
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1435..1461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1502 AA; 164198 MW; AEF63A266216FF3C CRC64;
MSESAKAAAQ NGQAEEQQLQ QQLDEQQQLE EQQQLPPVTI RIPSPTCSRT VPKPKDSTEP
LDRITLYPQP QETIQDIKLL INDWVGAYWL GPYSLQLPFV KGEDGRGKIY SKKKDFSEVR
AGEKLNEWLE VQDAFEHLQE GEERVLEAVR EPYGELSARQ SIIRLLELIA PSGTTANTTS
NPLGLQAGST IFEQVRDGLV SANAETTYEE VEVSLPSGRK GKGGKKELVK VKRSVSGDKA
HAFADWKGWA PASFGSLAVS SDPVEVAPSL KSIQISHFNP PPPHLRQKGH ELYLQVSLLE
GEVVTLICST RGWYVSKSNV NNFDPSPRPS ADGSIPAPTH SLIDLLHSIS PLFSERVSRL
PPISLDGALA DPISTVAIPQ ATPAYPFLTS PPKPAISPEI LRTQLAFLHT GAYGPDLVDA
ARDWNEEIQG IRELPRGTMQ ERVFREKMLQ KVWAEFDQAA ARAVQAVSKG DIPPINPAED
PKAHMYLQSN IFITQGDSDA LDTYAHLGGD AAMRISHGKD AAGVKLLNKI DADGLYLLGH
TIVDWQGRRW ICQSILPGIF SNRRAVEEEK AQAETEAEAE TADAVEGEQK KEDWVDVEKP
TEKSGSETES DNPMMIYGLD SERPTSVHWD AATHSLLSTI ATPLRLAAHT IKDGEGKEHE
FYASAEVKGL KGQDGRRYLL DAQRLAPVDV EWLEKDITGP LVGPKKDDES AEEGVQYPHR
LVMLRPELIE QFWESELKRW ARGVAEKAQA KKAEAEAEAA AAADAEGEKK KEGEQSEIPQ
EEQSAAASAA AARRAEEDRP VDASLIGDIK QFNLSFNPDA FVEQPVLEAE GQEGKTEIKA
AITDESDPSV KAVRDAGLFL RQIAIPAVVL DVLTGNTSGV MDGESLSKHL HQRGVNIRYL
GHLASTIIQF STSKDGAAKE PSGHLAALQS IVLQEMVFRA AKHILRELLY PLQPETATDA
VSHFLNCLLG SCLNPAPVAS YTPIGINSNE PEPAYVKLTP ECLRAQIIKE VKSRFRWTLD
ESFLESGLRK KQLLRELASR VGFQLAQREY VFSKDQEEEE NKREENIKSK EKKKGSKAGA
KGETVKRTTT FEGEDVLTLV PVIKSTAPSV SVAEEILEAG RNTINRGKIE FGLDFMLEAI
QLYESIHSVI HPEVASVYNS YAQAIHQIAR LKIQQIAAQE NPDPEQPLGV DISGALRFQR
QAVAIAERTL GVYHHETAGY YFQLAMLENL EGNAQQSLRY FRHLLTLWDV IYGPGHPEIS
TILSNAGIVL QSMNDLSLSL SLQKQAYEST LACFGPNHIQ TGQSLHQLVQ GHFLAGDMAS
ALETAKQALE IFKARLGEEH NQTKEEAKNV ELLTAVIENQ ERQKEREEAV KKEATERLKM
ARERIGGGAA STSRPTGIRR LGGAGAGALP QGVRVVDPQT LAALAAAAGQ GGNPSANAAA
ATAGQGEQAN GESTGTPQIG ERGTESLEEL VRYIQGSAPG VGGSAKRGKN ALRGKRRTGA
KR
