CLU_CULQU
ID CLU_CULQU Reviewed; 1377 AA.
AC B0W2S0;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN ORFNames=CPIJ001445;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB;
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; DS231828; EDS29823.1; -; Genomic_DNA.
DR RefSeq; XP_001843004.1; XM_001842952.1.
DR AlphaFoldDB; B0W2S0; -.
DR SMR; B0W2S0; -.
DR STRING; 7176.CPIJ001445-PA; -.
DR PRIDE; B0W2S0; -.
DR GeneID; 6032399; -.
DR KEGG; cqu:CpipJ_CPIJ001445; -.
DR VEuPathDB; VectorBase:CPIJ001445; -.
DR VEuPathDB; VectorBase:CQUJHB016298; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR InParanoid; B0W2S0; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR PhylomeDB; B0W2S0; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1377
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366378"
FT DOMAIN 353..595
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 519..552
FT /note="TPR 1"
FT REPEAT 1022..1055
FT /note="TPR 2"
FT REPEAT 1148..1181
FT /note="TPR 3"
FT REPEAT 1183..1216
FT /note="TPR 4"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1310..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1377 AA; 154112 MW; F97A9841848990AB CRC64;
MLKSIQRNGK KQKNGSKDKE PTPPKEQPLV NGNHDMNGHA SDSVAPTEQQ NGETKKKSDS
EVMEIIQDAG FTVQIMSPGV EPLSIQVSSM ELVQEIHQLL MDREDTCHRT CFSLQLDGVT
LDNFAELKNV EGLKEGSVIK VVEEPYTMRE ARIHVRHVRD LLKSMDPADA YNGVDCSSLT
FLHTITAGDI LEKKKGRSDS VDCTPPEYIM PGAKERPLLP LQPGVGKKGP QPLKVLTTSA
WNPPPGPRKL HGDLMYLYVV TMEDKRFHIS ACPRGFYINQ STDDTFEPRP DNPSYLCHSL
IDLLSQISPT FRRCFAQMQK KRTQRHPFER VATPYQVYTW SAPTLDHTID AIRAEDTFSS
KLGYEEHIPG QTRDWNEELQ TTRELPRETL PERLLRERAI FKVHSDFVTA ATRGAMAVID
GNVMAINPGE DAKMQMFIWN NIFFSLGFDV RDHYKELGGD AAAFVAPRND LHGVRVYSAV
DVEGLYTLGT VVIDYRGYRV TAQSIIPGIL EREQEQSVVY GSIDFGKTVL SHEKYLELLN
NAGKHLKIYP HSVLNDDEEE IELCSSVECK GIIGNDGRHY ILDLLRTFPP DVNFLKLDEE
LSKDCKAFGF PIEHKHKLSC LRQELLEAFI ESRYLLFIKH AAFQLQQLNT NKRQQKQDTP
KEETKAIEPA AKEDSANNNK EEPAAKKGEP KAATGGVPKV ETEEAKKLME SLLSSDEKNE
SREVVKRACE AVGSLKDYEF DIRFNPDVYS PGIQHVDNPN AANSIKKQKQ LVKDAAEFLV
KHQIPSFVHD CLDHTAAPMD GSTLTETLHS RGINVRYLGK VANLLAKIKQ LEYLHTIAVS
ELIIRAAKHI FVTYMQNTEM MSMAAAISHF LNCFLTTATS VSSESDVLTK SGSSGKQQRK
QNKRTAAGGG KGGKSSFQCT QDNNEWQLLT SKSLWAQIQQ ELKSYWDYDL LPAGTVDSAD
PVVTHNHLQK ISLLRAFCLK TGVQILLREY NFETKNKPTF NENDIVNVFP VVKHINPRAS
DAYNFYTTGQ TKIQQGYFKD GYDLISEALN LLNNVYGAMH PENAQCLRML ARLSYIMGDP
QEALAIQQRA VLMSERVNGI DHPYTIAEYA PLALYCFANS QISTALKLLY RARYLATIVC
GDNHPDIALL DSNISLILHA VGEYELSLRF LEHALALNIK YYGEKSLKVA VSYHLVARTQ
SCMGDFRSAL NNEKETYAIY KQQLGEAHEK TQESSECLRH LTQQAVVLQK KMNDIYSNGK
LTTGLPPIHI QPPSMGSVLD MLNAINGIIF VQISSKEIAN LKNEIEKRQK EGGAAGESSV
AQANQEEVDR LLTETMAKTA AGIPFEEQDN YELPLPAATT GDEASSSSKA NPVASSS
