ID   CLU_DANRE               Reviewed;        1400 AA.
AC   A0JMD0; Q5CZT5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=cluh {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=zgc:152873;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; BC090714; AAH90714.1; -; mRNA.
DR   EMBL; BC125829; AAI25830.1; -; mRNA.
DR   RefSeq; NP_001071028.1; NM_001077560.1.
DR   AlphaFoldDB; A0JMD0; -.
DR   SMR; A0JMD0; -.
DR   STRING; 7955.ENSDARP00000047470; -.
DR   PaxDb; A0JMD0; -.
DR   PeptideAtlas; A0JMD0; -.
DR   PRIDE; A0JMD0; -.
DR   GeneID; 562666; -.
DR   KEGG; dre:562666; -.
DR   CTD; 562666; -.
DR   ZFIN; ZDB-GENE-061103-457; cluha.
DR   eggNOG; KOG1839; Eukaryota.
DR   InParanoid; A0JMD0; -.
DR   OrthoDB; 60958at2759; -.
DR   PhylomeDB; A0JMD0; -.
DR   PRO; PR:A0JMD0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR   GO; GO:0048312; P:intracellular distribution of mitochondria; ISS:UniProtKB.
DR   GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.30.2280.10; -; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS51823; CLU; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1400
FT                   /note="Clustered mitochondria protein homolog"
FT                   /id="PRO_0000366374"
FT   DOMAIN          380..622
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REPEAT          1088..1121
FT                   /note="TPR 1"
FT   REPEAT          1130..1163
FT                   /note="TPR 2"
FT   REPEAT          1172..1205
FT                   /note="TPR 3"
FT   REPEAT          1214..1247
FT                   /note="TPR 4"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          56..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          684..741
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1377..1400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..227
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        708..741
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        1304
FT                   /note="L -> S (in Ref. 1; AAH90714)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1400 AA;  155810 MW;  515A6C85819C1ED9 CRC64;
     MVSKTDDIPA SVPNCSPADF ARDGETANSK GTTSKKEASC ACGHGVETAV MNGDAGHDQA
     EEADSKQDGS GDADQAEDAN EQEVIVIQDT GFTVKIQAPG TEPFDLQVSP QEMVQEIHQV
     LMDREDTCHR TCFSLQLDGN VLDNFAELKS IEGLQEGSLL KVVEEPYTVR EARIHVRHIR
     DLLKSLDPSD AYNGVDCNSL SFLSVFSEGD LGDTGKRKKK GSELEQIDCT PPEHILPGSK
     ERPLVPLQPQ NKDWKPMQCL KVLTMSSWNP PPGNRKMHGD LMYLYIVTVE DRHVSITAST
     RGFYLNQSTT YNFSPKPANP SFLSHSLVEL LSQISAAFKK NFTTLQKKRV QRHPFERIAT
     PFQVYSWTAP QIDHAMDCVR AEDAYTSRLG YEEHIPGQTR DWNEELQTTR ELSRKNLPER
     LLRERAIFKV HSDFAAAATR GAMAVIDGNV MAINPGEETR MQMFIWNNIF FSLGFDVRDH
     YRELGGDSAA HAAPTNDLNG VRAYSAVDVE GLYTLGTVVV DYRGYRVTAQ SIIPGILERE
     QEQSVIYGSI DFGKTVVSHP KYLELLEKTS RPLKVQRHAV LNEKDSAVEL CSSVECKGII
     GNDGRHYILD LLRTFPPDLN FLPVEGEELT PESQKLGFPR QHRHRLACLR QELIEAFVEH
     RYLLFMKMAA LQLMQQKANK DKTAALQDSN AAGAGSENKP LALESCDGTP DSPTSSESTL
     TPEDSEATTV SENSSAENQE AMTEVPVASI NGTHEPLAAE RQNGGCDGPL EGKEADENIP
     GLAQAKELAE SLAAEDGSGI DPKSREVVLN ACKAVGSISN TSFDIRFNPD IFSPGVRFPD
     DSNDDIKKQK QLLKDAAAFL VSCQIPSLVK DCLDHSSLPM DGATLTEALH QRGINVRYLG
     TVLEFMDNMP AKAQLEHIYR IGISELITRC AKHIFKTYLQ GVDLSALSAA VSYFLNCLLS
     SFPDAVAHLP ADELVSRKKS RKRRNRVPGG GDNTAWASLT PSELWKNITS EAHGYYNFSL
     QCESVDQAVE KYGLQKITLL REISIKTGIQ ILIKEYNFDS RHKPAFTEED ILNIFPVVKH
     VNPKASDAFH FFQSGQAKVQ QGFLKEGCEL INEALNLFNN VYGAMHVEIC ACLRLLARLN
     YIMGDHPEAL SNQQKAVLMS ERVLGIEHPN TIQEYMHLAL YCFANGQLST ALKLLYRARY
     LMLVVCGEDH PEMALLDSNI GLVLHGVMEY DLSLRFLENA LAINTKYHGP RSLKVALSHH
     LVARVYESKA EFRSALQHEK EGYTIYKNQV GEAHEKTKES SEYLKYLTQQ AVALQRTMNE
     IYKNGSNASI MPLKFTAPSM ASVLEQLNII NGIIFIPLSQ KDLENLKAEV QRRQLMQDSG
     KIQEQQGSHL ELDDKLPVDD