CLU_DEBHA
ID CLU_DEBHA Reviewed; 1323 AA.
AC B5RSP9;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013};
GN OrderedLocusNames=DEHA2A03102g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CR382133; CAR65355.1; -; Genomic_DNA.
DR RefSeq; XP_002769962.1; XM_002769916.1.
DR AlphaFoldDB; B5RSP9; -.
DR SMR; B5RSP9; -.
DR STRING; 4959.XP_002769962.1; -.
DR EnsemblFungi; CAR65355; CAR65355; DEHA2A03102g.
DR GeneID; 8998111; -.
DR KEGG; dha:DEHA2A03102g; -.
DR VEuPathDB; FungiDB:DEHA2A03102g; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR InParanoid; B5RSP9; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR Proteomes; UP000000599; Chromosome A.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1323
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366404"
FT REPEAT 103..141
FT /note="TPR 1"
FT DOMAIN 351..608
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 530..563
FT /note="TPR 2"
FT REPEAT 1042..1076
FT /note="TPR 3"
FT REPEAT 1099..1132
FT /note="TPR 4"
FT REPEAT 1141..1174
FT /note="TPR 5"
FT REPEAT 1183..1216
FT /note="TPR 6"
FT REGION 149..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1323 AA; 149363 MW; 845EBEBD4BD5DDAD CRC64;
MSSDEASSEA LAQEDIKQIT LRIKLPACIS NEEDLEVPSL LSETLADIRE TLNLSAATQN
LTNFNVFYQD INLSENFDDL VPLNDILTEL GVGEIDSLNL VLKEKPYNLA AIYDHLNKFR
EVIGLHFLDK YSSEVGVLSG VSKFGDIDLQ DVKETEPETQ DDKDKETDET KSTKEDSNQT
EEKKSEIVFT AEEKQQIGKI TDELISGNTP SLVEFGTFDN ISGSIKTPIK SLTVSQWSPV
PSFQKLKGDL LYITLQTLEN ETLNITCHLS GFFVNKSSTI NFNPAIKMNE NGKVHKDYLL
INLVDSLSPS FSKTIQENEL VLSRSSKHPE SFLIPSNSLM SSPWIVNPSK FANQPDASRS
QLPLISNGVD GSGFVKEWNE DFQAIRELPN STINERILRE KLLMKSLHEF NKVATETAMN
VIKGNLTPLN PNEPKDYHIY LRNGIFYSLG VNATGAFDCT GGNEAARYTS SKDLAAIKLL
NRIDAKGIYN LVTCIVDYMG QRVICQAPVP GILDSSHEDE NEEEPTDKVC YGLSTDGSKI
FSDSSFENVL KPIAEAFHLK PHPVTLLDNV KSQGDLITSK DIKGVKGTDE RKYIIDLYRA
TPLDIEFIES NWDESKETSY PHRETALRHE AVEEWWKRKV SVLFKAETER LEKEGKLESK
DGEKPQIVLP SDQITINTDA FTTIDESSDD QNEVREVSKF IKEHLIEEFL EENSKQISPF
DGNHLTSMLH KQGINLRYLG HIAEQACVRK DEHLKKITEA RKVNEEEISK RKEESEKKAT
EGKDQDKEEE KANDNEKNKE DDKEEVSNGE FEPIVANFDS LYRISVQEMV ARSVKHLLRK
ISADIPVYLI PAFVSHFHNC LLGSEINSSP ECIIDETLKG FYNATELEFT KLNSNKVIAL
VANEVLIRFR YELPTDWIST LIRPFQLFRE IAIKYGIQWK SQEYAFTNEE FEKVKDKLAV
ETQVFEAKTS KHKKNKKQQS QLITKSVDRT TIFVTDDIVN FVPIVKDSTY RSSLVDEIFE
TARAQIFKGE TETGINLLNN LLSVYEQIYG RVHPETSKFY GLLSQYYAEL GLKSEACNIA
RKACILAERT TGFDSYESIT AYINSAFFES TNDDYINALN LYNKAINDWT LVYGDGHPSS
VNTYANLAEL LSEHKLFQQA NKLFEKAISI STKLNGEESQ ICGMLRYRYG GTLLGGGDFK
SALDQFKSAN DIFTKFIGPD DQLSKKSLSF VTNISTYLAY NEHQKSEQKK ALAQQASASN
GKVKAKSAVE QQLKSSKKGK KNDATQPNPE IASKSVDDIL QYIEGKNPKK QLKKKSNNKK
SKK
