CLU_DICDI
ID CLU_DICDI Reviewed; 1320 AA.
AC O15818; Q54CI7;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clua {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=DDB_G0292806;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=9207087; DOI=10.1073/pnas.94.14.7308;
RA Zhu Q., Hulen D., Liu T., Clarke M.;
RT "The cluA-mutant of Dictyostelium identifies a novel class of proteins
RT required for dispersion of mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:7308-7313(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP PROTEIN SEQUENCE OF 532-546; 592-605 AND 634-640, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC STRAIN=AX2;
RA Bienvenut W.V., Ura S., Insall R.H.;
RL Submitted (JUL-2009) to UniProtKB.
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013,
CC ECO:0000269|PubMed:9207087}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- DISRUPTION PHENOTYPE: Causes mitochondria to cluster within cells.
CC {ECO:0000269|PubMed:9207087}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U49332; AAC26527.1; -; mRNA.
DR EMBL; AAFI02000197; EAL60952.1; -; Genomic_DNA.
DR RefSeq; XP_629429.1; XM_629427.1.
DR AlphaFoldDB; O15818; -.
DR SMR; O15818; -.
DR STRING; 44689.DDB0215379; -.
DR PaxDb; O15818; -.
DR EnsemblProtists; EAL60952; EAL60952; DDB_G0292806.
DR GeneID; 8628948; -.
DR KEGG; ddi:DDB_G0292806; -.
DR dictyBase; DDB_G0292806; cluA.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR InParanoid; O15818; -.
DR OMA; VSGFYVN; -.
DR PhylomeDB; O15818; -.
DR PRO; PR:O15818; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IMP:dictyBase.
DR GO; GO:0000266; P:mitochondrial fission; IMP:dictyBase.
DR GO; GO:0008053; P:mitochondrial fusion; IMP:dictyBase.
DR GO; GO:0000281; P:mitotic cytokinesis; IMP:dictyBase.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..1320
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000123555"
FT DOMAIN 379..649
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 955..988
FT /note="TPR 1"
FT REPEAT 997..1030
FT /note="TPR 2"
FT REPEAT 1039..1072
FT /note="TPR 3"
FT REPEAT 1081..1114
FT /note="TPR 4"
FT REPEAT 1123..1156
FT /note="TPR 5"
FT REGION 166..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1204..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 22
FT /note="G -> GEQV (in Ref. 1; AAC26527)"
FT /evidence="ECO:0000305"
FT CONFLICT 97..98
FT /note="SE -> Q (in Ref. 1; AAC26527)"
FT /evidence="ECO:0000305"
FT CONFLICT 158..161
FT /note="KSNI -> NQY (in Ref. 1; AAC26527)"
FT /evidence="ECO:0000305"
FT CONFLICT 1166
FT /note="E -> Q (in Ref. 1; AAC26527)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1320 AA; 148687 MW; 3EF4E6D787621958 CRC64;
MSETIDNPTV EEYNEKETVV SGEQVEQVEQ VEQENEQVSQ SFQISIKTPA EIGTINIQVQ
PTDTLIDIQS FLYETSETCL YSSFEFRLYG KQIPEYSELS SIEGLVEGAT LEMVPVDYNE
RSAKLHVKRL RDIMNTGLTE FANMNNPSLF TSFSFPEKSN ILTEEQQLEE QKQKFEQQQQ
QQQQTEDKEE KETIATEQQQ NKKNKHHNKK GNKKNNGDES LNNENNEEKL TPQQKERKQK
MTEIKGIDKP MLSSYYPESP IAPVQCVKSM IYSGWSPVPG YRKLFGDLFY LDITLLEGTT
ICVTASTQGF FINQSSNATF NPSVSPKATI NHSLHQLLTQ VSRLFRRGLN QILTNIGRNH
PFDMLPGVLP VHNWVASSKT NRYDINKGTD TFVSVQDVEL RGNPRDWNEE IQAPKELPKS
TVQERIIRDR AISKVNSEFV ECAIRGAQVI VDKAILPINP AENQRSHMFL YNNIFFSYAL
DTRDSFTDCG GDDAARTSAN NDLKGIRLYN LADIDGLYTL GTAIVDYKGQ RIIAQSLIPG
ILTTEKTSKI YYGSMDTPTN EEEEQQQKEE NEENKNNNTK SIKADPEFHS RLLQAASLLH
LSESKVISED TNQEVSVCTS FESKGIIGID GRRYILDLIK ATPRDPNYTE TKDQLSVLRP
EAIATYSEYF KVTWLNQKRQ QKLKEKEERQ KKEGIDPPTA TARDEDVQLT EEDLAQSPVV
SFNPNLFSKV KLGGTPEEQQ KDIEDLKAIG AFLKGILIPR LIEDLMLFNV APVDGQTLTQ
VMHVRGINMR YLGYIAKNES ANVPFIQDLL FNEMVSRAAK HCFNRLLRST NASDMAHSIS
HFLNCFLGTE TGSVSADEKS KKAKQIKSSA INELTQGKLW SEIAQLVSSK FDFEIPTHSV
PMESRLIVLR CICLKMGIQI LAKDYNFTTD APFSPEDIVD LFPIVKHVNP RSTDGLDLLE
AGKTFFNQRK YELATELLGE ALAIYHQVHG PIHPDAGACF THLAMLAYQN EQYDLAIEYQ
KNALVITEKT AGLDHHETVQ AYTTLAVFCQ RSGRYNESIG YMKHVLYLTD LLGGEYNPER
ASIYTAIAAI LEDTERFDLA LEFLKQTLKH QEFLFTPDHL MCSTTYHKMA IVCARATNFD
DSIIHQKKST DILEKELGEA HPRTKESLEF YTGLSQTANQ IKLFKQHQAL KAEQDELARL
QKEKADQFKK SQPRVSAMPP SLENGSVSEL LNYINGKPKK SQSKKSKSTN TTTTTNTTTA
TTSKSKITMA KTPNPTTKAT TSKSSATASS AATNKSTTKT NPTSSSAADS SKPNKKSSKN
