CLU_DROAN
ID CLU_DROAN Reviewed; 1450 AA.
AC B3MIW0;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Protein clueless {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=GF12179;
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH902619; EDV36020.1; -; Genomic_DNA.
DR RefSeq; XP_001959198.1; XM_001959162.2.
DR AlphaFoldDB; B3MIW0; -.
DR SMR; B3MIW0; -.
DR STRING; 7217.FBpp0115371; -.
DR EnsemblMetazoa; FBtr0116879; FBpp0115371; FBgn0089218.
DR GeneID; 6495035; -.
DR KEGG; dan:6495035; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR InParanoid; B3MIW0; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR PhylomeDB; B3MIW0; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0031315; C:extrinsic component of mitochondrial outer membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblMetazoa.
DR GO; GO:0072686; C:mitotic spindle; IEA:EnsemblMetazoa.
DR GO; GO:0098799; C:outer mitochondrial membrane protein complex; IEA:EnsemblMetazoa.
DR GO; GO:0003729; F:mRNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0043022; F:ribosome binding; IEA:EnsemblMetazoa.
DR GO; GO:0055059; P:asymmetric neuroblast division; IEA:EnsemblMetazoa.
DR GO; GO:0051646; P:mitochondrion localization; IEA:EnsemblMetazoa.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1450
FT /note="Protein clueless"
FT /id="PRO_0000366379"
FT DOMAIN 425..667
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1102..1135
FT /note="TPR 1"
FT REPEAT 1228..1261
FT /note="TPR 2"
FT REPEAT 1263..1296
FT /note="TPR 3"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1410..1450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..769
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1428..1450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 271
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1450 AA; 161078 MW; 9EF4AD43F89067C5 CRC64;
MALETDAKNS NAVAPGDAAT VATTKAKENN SSAGKKQQQQ QQPNQNQNLV NGNGNAADGP
AAKKKGKKNR NKSPPEPAAE PVEASLSNGH AEKTTSEEGG DTAAPDTNAN VGEKSEDGGG
AAPGSELETE DIDLDALHEV GITVNISSPG ADILSVQLSS MELVQEIHQL LMDREETCHR
TCFSLQLDNV TLDNFAELKT IEQLEQGSTI RVVEEPYTMR EARIHVRHVR DLLKNLDPAD
AYNGIDCTSL TYLNTITQGD LLDKKKTRPD SVDCTPPEYV TPGVSEPPLL PLHPNIKNAK
GPQALKVLTT SAWNPPPGPR KLHGDLMYLY VVTMEDKRFH ISACSKGFYI NQSTDDTFNP
KPDNPSHLSH SLIDLLSHIS PSFRRAFQTI QKRRTTRHAF ERVATPYQVY QWASPVLEHT
VDAIRAEDAF SSKLGYEEHI PGQTRDWNEE LQTTRELPRK TLPERLLRER AIFKVHGDFV
TAATRGAMAV IDGNVLAINP GEDAKMQMFI WNNIFFSLGF DVRDHYKELG GDAAAFVAPR
YDLHGVRVYN AVDVEGLYTL GTVVIDYRGY RVTAQSIIPG ILEREQEQSV VYGSIDFGKT
VLSHPKYLDL LRQAGKHLKI LPHAVLNERD EPVELCSSVE CKGIIGNDGR HYILDLLRTF
PPDVNFLKLP EVQLSKELVD MGFPIEHRHK LCCLRQELLE AFIEDRYVSF IRIAAVHLQQ
LNAKKQSEKT EEKALPALEE AEKESSETKE AEAEKPVEKK EEEKQQPSSN ETKTAEAMVN
AIREAQSNVA TSNEVQAAEV VKRACAAVGS LKEKEFDFRF NPDVFSNGIR HVDGEEGTCS
SLAKQKVLVQ DAAEFLVVKQ IPAFIKEHLA HSSPPIDGQS LTESLHSHGI NVRYLGKVIK
LLAQMPRMDY LHRIAVLELI VRATKHIYYT YMQNTEPLHL SAAISHFLNC LLTTGPVNPA
VSSEEAHKKR SNGNKHNKHK SKGNKQQASG NQNGSSAGSS SGGSSSSSDW TLVTPRSLWQ
QIRREAKSYW DWELDCDSIE TAVSKYGILR ISLLRAFCLK VGIQVLLREY NFESKHKPTF
GDEDIVNVFP VVKHISPRAT DAYNFYTTGQ AKIQQGMFKE GYELISEALN LLNNVFGAMH
QENGSCLRML ARLSYLLGDA QDALAIQQRA VIMSERVNGI DHPSTILEYT HLSLYSFANG
HVGMSLKLLY RARYLMVLIC GEDHPEVALI DSNISLILHA LGEYELSLRF IEHALKLNIK
YFGSKAMHVA FSYHLMARTQ SCMGDFRSAL NNEKETYSIY KSQVGEKHEK TRDSAECLRL
LTQQAVLLQR KMNDIYSNGK LTSDLPPIHI TPPSMGSVLD MLNTINGILF VQISQKDIVK
VRSEIEKHFK ANSAENEVND AIKSIVAAAN NNGDTEAETK DATKDNKDLA GASTQLTNGD
KDAETAVASS
