CLU_DROER
ID CLU_DROER Reviewed; 1452 AA.
AC B3NPV8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Protein clueless {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=GG20578;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH954179; EDV55805.1; -; Genomic_DNA.
DR RefSeq; XP_001975405.1; XM_001975369.2.
DR AlphaFoldDB; B3NPV8; -.
DR SMR; B3NPV8; -.
DR STRING; 7220.FBpp0139124; -.
DR EnsemblMetazoa; FBtr0140632; FBpp0139124; FBgn0112768.
DR GeneID; 6548523; -.
DR KEGG; der:6548523; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR PhylomeDB; B3NPV8; -.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0031315; C:extrinsic component of mitochondrial outer membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblMetazoa.
DR GO; GO:0072686; C:mitotic spindle; IEA:EnsemblMetazoa.
DR GO; GO:0098799; C:outer mitochondrial membrane protein complex; IEA:EnsemblMetazoa.
DR GO; GO:0003729; F:mRNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0043022; F:ribosome binding; IEA:EnsemblMetazoa.
DR GO; GO:0055059; P:asymmetric neuroblast division; IEA:EnsemblMetazoa.
DR GO; GO:0051646; P:mitochondrion localization; IEA:EnsemblMetazoa.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphoprotein.
FT CHAIN 1..1452
FT /note="Protein clueless"
FT /id="PRO_0000366380"
FT DOMAIN 426..668
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1414..1452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..769
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1434..1452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 272
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1452 AA; 160882 MW; A94A7FAED9EAF82D CRC64;
MALETEAKNS NATATSDATA TKASGKAKET NNTAGGKKNL NPIPNSNHQN SNQNLVNGNG
TAADGPAAKK KGKKNRNKSP PEPTTEAVLS NGHAEKSTLV DAVEDNADAD ANANVEKPED
GGAPDAEADG EDIDLDALQD VGITVNISSP GADLLCVQLS SMELVQEIHQ LLMDREETCH
RTCFSLQLDN ATLDNFAELK AISNLEQGST IKVVEEPYTM REARIHVRHV RDLLKNLDPA
DAYNGIDCTS LTYLNTITQG DLLDKKKTRP DSVDCTPPEY VTPGVSEPPL LPLHPNVKNA
KGPQALKVLT TSAWNPPPGP RKLHGDLMYL YVVTMEEKRF HISACSKGFY INQSTDDTFN
PKPDNPSHLS HSLIDLLSHI SPSFRRAFQT IQKRRTMRHA FERVATPYQV YQWASPTLEH
TVDAIRAEDA FSSKLGYEEH IPGQTRDWNE ELQTTRELPR KTLPERLLRE RAIFKVHGDF
VTAATRGAMA VIDGNVLAIN PGEDPKMQMF IWNNIFFSLG FDVRDHYKEL GGDAAAFVAP
RYDLHGVRVY NAVDVEGLYT LGTVVIDYRG YRVTAQSIIP GILEREQEQS VVYGSIDFGK
TVLSHPKYLE LLRQAGKHLK ILPHAVLNER DEPVELCSSV ECKGIIGNDG RHYILDLLRT
FPPDVNFLKL QDVQLSKELV DMGFPIEHRH KLCCLRQELL EAFIEDRHVS FIRIAAVHLQ
QLNAKKQSEK AEGNPVPALE GAEAVSKVNG ADKTDVKEEK NEENEKAQST AGDTKTAEAM
VNAIREAQSN VATSNEVQAA EVVKRACAAV GSLKEKEFDF RFNPDVFSPG IRHVDGEEGT
CSSLAKQKVL VQEAAEFLVL KQIPAFVKEH MTHSSPPIDG QSLTESLHSH GINVRYLGKV
IKILNQMPRM DYLHRIAVLE LIVRATKHIY YTYMQNTEPL HLSAAISHFL NCLLTNGPVN
PAVSSEEAHK KRGNGGKHNK HKSSKGGKGQ QQQQATGNQN GSSSGSSNGS SVSDWTLMTP
RSLWQQIRKE AKVYWDWELD CDSIETAVSK YGILRISLLR AFCLKVGIQV LLREYNFESK
HKPTFGDDDI VNVFPVVKHI SPRATDAYNF YTTGQAKIQQ GMFKEGYELI SGALNLLNNV
FGALHQENGS CLRMLARLSY LLGDAQDALA IQQRAVIMSE RVNGMDHPST ILEYTHLSLY
SFANGHVGMS LKLLYRARYL MVLICGEDHP EVALIDSNIS LILHALGEYE LSLRFIEHAL
KLNLKYFGDK AMPVALSYHL MARTQSCMGD FRSALNNEKE TYSFYKSQLG ENHEKTKDSA
ECLRLLTQQA VLLQRKMNDI YSSGKLTSDL PPIHITPPSM GSVLDMLNTI NGILFVKISR
KDIVKVRSEI EKHFKADSPE NEVNDAISSI VAAANNNGEA EDAVPKDVEE QKEAGTQLTN
GEKAAATEAT SS
