ID   CLU_DROGR               Reviewed;        1494 AA.
AC   B4JW99;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Protein clueless {ECO:0000255|HAMAP-Rule:MF_03013};
DE   AltName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=clu {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=GH22778;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; CH916375; EDV98237.1; -; Genomic_DNA.
DR   RefSeq; XP_001995165.1; XM_001995129.1.
DR   AlphaFoldDB; B4JW99; -.
DR   SMR; B4JW99; -.
DR   STRING; 7222.FBpp0156684; -.
DR   eggNOG; KOG1839; Eukaryota.
DR   HOGENOM; CLU_003256_1_0_1; -.
DR   InParanoid; B4JW99; -.
DR   OMA; VSGFYVN; -.
DR   PhylomeDB; B4JW99; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR   GO; GO:0031315; C:extrinsic component of mitochondrial outer membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblMetazoa.
DR   GO; GO:0072686; C:mitotic spindle; IEA:EnsemblMetazoa.
DR   GO; GO:0098799; C:outer mitochondrial membrane protein complex; IEA:EnsemblMetazoa.
DR   GO; GO:0003729; F:mRNA binding; IEA:EnsemblMetazoa.
DR   GO; GO:0043022; F:ribosome binding; IEA:EnsemblMetazoa.
DR   GO; GO:0055059; P:asymmetric neuroblast division; IEA:EnsemblMetazoa.
DR   GO; GO:0051646; P:mitochondrion localization; IEA:EnsemblMetazoa.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.30.2280.10; -; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR007967; GSKIP_dom.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601; PTHR12601; 2.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF05303; DUF727; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS51823; CLU; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1494
FT                   /note="Protein clueless"
FT                   /id="PRO_0000366381"
FT   DOMAIN          432..674
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REPEAT          1138..1171
FT                   /note="TPR 1"
FT   REPEAT          1264..1297
FT                   /note="TPR 2"
FT   REPEAT          1299..1332
FT                   /note="TPR 3"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          733..783
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          969..1044
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1450..1494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        733..775
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        994..1044
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1477..1494
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         278
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1494 AA;  164450 MW;  C80EBBAD7284BCB9 CRC64;
     MALEIDAKNA TAATGDAGGA TGGKAKAKEN KTNNNNNAAG EKNLVNGSSS SSAAAAAKKK
     GKKNRNKSPP QQDAIEAEAG AALSNGHAVN GVGDGDADAA DANANVLADK PDKATAAAEE
     KSATPDDEAA AAVAAGDDAD LDALNDIGIT VNISSPGTDV LSVQLSSMEL VQEIHQLLMD
     REETCHRTCF SLQLDNVTLD NFAELKTIEP LEQGSTIRVV EEPYTMREAR IHVRHVRDLL
     KNLDPADAYN GIDCTSLTYL NTITQGDLLD KKRTRPDSVD CTPPDYVTPG VREPPLLPLH
     PNIKNAKGPQ ALKVLTTSAW NPPPGPRKLH GDLMYLYVVT MEDKRFHISA CSKGFYINQS
     TDDNFNPKPD NPSHLSHSLI DLLSHISPSF RRAFQAIQKR RTMRHAFERV ATPYQVYQWS
     APQLEHTVDA IRAEDAFSSK LGYEEHIPGQ TRDWNEELQT TRELPRKTLP ERLLRERAIF
     KVHGDFVTAA TRGAMAVIDG NVLAINPGED AKMQMFIWNN IFFSLGFDVR DHYKELGGDH
     AAFVAPRYDL HGVRVYNAVD VEGLYTLGTV VIDYRGYRVT AQSIIPGILE REQEQSVVYG
     SIDFGKTVLS HPKYLELLRL AGKHLKILPH SVLNERDEPV ELCSSVECKG IIGNDGRHYI
     LDLLRTFPPD VNFLKLEDVQ MSKDLSEMGF PIEHRHKLCC LRQELLEAFI EDRYVTFIRI
     AAAHLQRLNA KKQADKDLPE EQSTEKPTEQ SAEKDPMEKE QDKEKEKDKE AKPNTSSTET
     KSAEAMVNAI REAQSNVAVS NEVQAAEVVK RACATVGSLK EKEFDFRFNP DVFSPGIRHI
     DGPDGGGQSL AKQKRLVQDA AEFLVLKQIP AFIKEHTAHS SPPIDGQSLT ESLHSHGINV
     RYLGKVIKML GQMPRMDYLH RIAILELIVR ATKHIYYTYM QSTEPLHLSA AISHFLNCLL
     TTGPVNPAVS SEEVHKKQLR NNGGKHNKHN KSSKSQAKPQ SSSSSSSSAA ASTQNGGNNH
     NSNNSTAAAA GAASSSSASN NSSADWTLVT PRSLWQQIRK ETKAYWNFEL DCDSVETAGA
     KYGFLRISLL RAFCLKVGIQ VLLREYNFES KHKPTFGDDD IVNVFPVVKH ISPRATDAYN
     FYTTGQAKIQ QGLLKEGYEL ISEALNLLNN VFGAMHQENG SCLRMLARLS YLLGDAGDAL
     AIQQRAVIMS ERVNGIDHPS TILEYTHLSL YSFANGHVGM SLKLLYRARY LLVLICGEDH
     PEVALIDSNI SLILHALGEY ELSLRFIEHA LKLNRKYFGD KAMHVAVSYH LMARTQSCMG
     DFRSALSNEK ETYSIYKSQM GEKHEKTRES AECLRLLTHE AVALQRKMND IYSNGKLTSD
     LPPIHITPPS MGSVLEMLNT INGILFVHIS QKDIVKVRSE IEKHLKTNTD ENEITDALKT
     IVAAANNNEN ATETTKDEGA AAAGAAPGAG ETPVQLTNGG GEETTATATA TVSS