CLU_DROMO
ID CLU_DROMO Reviewed; 1487 AA.
AC B4KT50;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Protein clueless {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=GI20574;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH933808; EDW09570.1; -; Genomic_DNA.
DR RefSeq; XP_002005635.1; XM_002005599.2.
DR AlphaFoldDB; B4KT50; -.
DR SMR; B4KT50; -.
DR STRING; 7230.FBpp0169791; -.
DR EnsemblMetazoa; FBtr0171299; FBpp0169791; FBgn0143310.
DR GeneID; 6579753; -.
DR KEGG; dmo:Dmoj_GI20574; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR InParanoid; B4KT50; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR PhylomeDB; B4KT50; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0031315; C:extrinsic component of mitochondrial outer membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblMetazoa.
DR GO; GO:0072686; C:mitotic spindle; IEA:EnsemblMetazoa.
DR GO; GO:0098799; C:outer mitochondrial membrane protein complex; IEA:EnsemblMetazoa.
DR GO; GO:0003729; F:mRNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0043022; F:ribosome binding; IEA:EnsemblMetazoa.
DR GO; GO:0055059; P:asymmetric neuroblast division; IEA:EnsemblMetazoa.
DR GO; GO:0051646; P:mitochondrion localization; IEA:EnsemblMetazoa.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 2.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1487
FT /note="Protein clueless"
FT /id="PRO_0000366383"
FT DOMAIN 438..680
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1140..1173
FT /note="TPR 1"
FT REPEAT 1266..1299
FT /note="TPR 2"
FT REPEAT 1301..1334
FT /note="TPR 3"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1456..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1040
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 284
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1487 AA; 164596 MW; 21E2AF1ABD70E5E4 CRC64;
MALEIDAKNA AAAATGDGGA PGKAKAKENK SNSNSNNNNV PAAGEKNLVN GSSAATKKKG
KKNRNKSPPQ QDVSAAGAAL SNGHAEKASV NGDAADANAN VLDKKVEEEG ATAAAGATEA
AAEVGSSGDG GAATEGEAAA SGEDVDLDAL HDVGITVNIS SPGADVLSVQ LSSMELVQEI
HQLLMDREET CHRTCFSLQL DNVTLDNFAE LKTIEGLEQG STIRVVEEPY TMREARIHVR
HVRDLLKNLD PADAYNGIDC TSLTYLITIT QGDLLDKKRT RPDSVDCTPP DYVIPGVREP
PLLPLHPNIK NAKGPQALKV LTTSAWNPPP GPRKLHGDLM YLYVVTMEDK RFHISACSKG
FYINQSTDEC FNPKPDNPSH LSHSLIDLLS HISPSFRRAF QTIQKRRTMR HAFERVATPY
QVYQWSAPQL EHTVDAIRAE DAFSSKLGYE EHIPGQTRDW NEELQTTREL PRKTLPERLL
RERAIFKVHG DFVTAATRGA MAVIDGNVLA INPGEDPKMQ MFIWNNIFFS LGFDVRDHYK
ELGGDHAAFV APRYDLHGVR VYNAVDIEGL YTLGTVVIDY RGYRVTAQSI IPGILEREQE
QSVVYGSIDF GKTVLSHPKY LELLRLAGKH LKILPHSVLN ERDEPVELCS SVECKGIIGN
DGRHYILDLL RTFPPDVNFL KLQDVQLSKE LTDMGFPIEH RHKLCCLRQE LLEAFIEDRY
VTFIRIAAVH LQQLNAKKQA EKELPSITEK QEEPEKEQAE KSSAEQPEKE KEKEKDKEDE
QKESKPSPTE TKSAEAMVNA IREAQSNVAV SNEVQAAEVV KRACAAVGSL KEKEFDFRFN
PDVFSPGIRH VDSPESGAQS LAKQKRLVQD AAEFLVLKQI PAFIKEHMAH SSPPIDGQSL
TESLHSHGIN VRYLGKVIKM LSQMPRMDYL HRIAILELIV RATKHIYYTY MQSTEPLHLS
AAISHFLNCL LTTGPVNPAV SSEEVHKKQS RNNGGKHNKH NKSNKSGKPQ STSAAAATQN
GHSSTAANGS ANSAANTAST SGNSNYDWTL VTPRSLWQQI RKEIKSYWNW ELDCDSIESA
CAKYGLLRIS LLRAFCLKVG IQVLLREYNF ESKHKPTFGD DDIVNVFPVV KHISPRATDA
YNFYTTGQAK IQQGLLKEGY ELISEALNLL NNVFGAMHQE NGSCLRMLAR LSYLLGDAQD
ALAIQQRAVI MSERVNGIDH PSTILEYTHL SLYSFANGHV GMSLKLLYRA RYLLVLVCGE
DHPEVALIDS NISLILHALG EYELSLRFIE HALKLNLKYF GNKAMHVAVS YHLMARIQSC
MGDFRSALNN EKETYSIYKS QLGEKHDKTR ESAECLRLLT HEAVALQRKM NDIYSNGKLT
SDLPPIHITP PSMGSVLEML NTINGILFVH ISQKDIVKVR SQIEKHLKTS DESGPNDDNE
VTAALKTFVA AINYNDTEQP KEGSEVEGAT ATQLTNGSED STTTVSS
