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CLU_DROPE
ID   CLU_DROPE               Reviewed;        1435 AA.
AC   B4GAM1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Protein clueless {ECO:0000255|HAMAP-Rule:MF_03013};
DE   AltName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=clu {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=GL11405;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; CH479181; EDW31973.1; -; Genomic_DNA.
DR   RefSeq; XP_002016083.1; XM_002016047.1.
DR   AlphaFoldDB; B4GAM1; -.
DR   SMR; B4GAM1; -.
DR   STRING; 7234.FBpp0175512; -.
DR   EnsemblMetazoa; FBtr0177020; FBpp0175512; FBgn0149014.
DR   GeneID; 6590515; -.
DR   KEGG; dpe:6590515; -.
DR   eggNOG; KOG1839; Eukaryota.
DR   HOGENOM; CLU_003256_1_0_1; -.
DR   OMA; VSGFYVN; -.
DR   PhylomeDB; B4GAM1; -.
DR   Proteomes; UP000008744; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR   GO; GO:0031315; C:extrinsic component of mitochondrial outer membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblMetazoa.
DR   GO; GO:0072686; C:mitotic spindle; IEA:EnsemblMetazoa.
DR   GO; GO:0098799; C:outer mitochondrial membrane protein complex; IEA:EnsemblMetazoa.
DR   GO; GO:0003729; F:mRNA binding; IEA:EnsemblMetazoa.
DR   GO; GO:0043022; F:ribosome binding; IEA:EnsemblMetazoa.
DR   GO; GO:0055059; P:asymmetric neuroblast division; IEA:EnsemblMetazoa.
DR   GO; GO:0051646; P:mitochondrion localization; IEA:EnsemblMetazoa.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 2.
DR   Gene3D; 3.30.2280.10; -; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR007967; GSKIP_dom.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF05303; DUF727; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS51823; CLU; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1435
FT                   /note="Protein clueless"
FT                   /id="PRO_0000366384"
FT   DOMAIN          420..662
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REPEAT          1096..1129
FT                   /note="TPR 1"
FT   REPEAT          1222..1255
FT                   /note="TPR 2"
FT   REPEAT          1257..1290
FT                   /note="TPR 3"
FT   REGION          1..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          719..762
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          952..998
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1407..1435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..95
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        721..762
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        976..998
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         266
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1435 AA;  160351 MW;  8095C6B00A9D349E CRC64;
     MALEMDSKNS NSAVTGDAAA ATTKTNKAKE NNNLAGSKKN QSQNLVNGNG TAADGPATKK
     KGKKNRNKSP PVSTDEAALS NGHVEEKKPE GDGDADADAN ANVVAVKDEK AEGGDEADAA
     ELDTEDIDLD ALHDAGIHVN ISCPGSELLT VQLSSMELVQ EIHQLLMDRE ESCHRTCFSL
     QLDNVTLDNF AELKTIEQLE SGSTIKVVEE PYTMREARIH VRHVRDLLKN LDPADAYNGI
     ECTSLTYLNT ITQGDLLDKK KTRPDSVDCT PPDYVTPGVF EPPLLPLHPN FKNAKGPQAL
     KVLTTSAWNP PPGPRKLHGD LMYLYVITME EKRYHISACS RGFFINQSTD DTFNPKPDNP
     SYLSHSLIDL LSHISPSFRR AFQAIQKRRT LRHAFERVAT PYQVYQWAAP NLEHTVDAIR
     AEDAFSSKLG YEEHIPGQTR DWNEELQTTR ELPRKTLPER LLRERAIFKV HGDFVTAATR
     GAMAVIDGNV LAINPGEDSK MQMFIWNNIF FSLGFDVRDH YKELGGDYAA YVAPRYDLHG
     VRVYNAVDVE GLYTLGTVVI DYRGYRVTAQ SIIPGILERE QEQSVVYGSI DFGKTVLSHP
     KYLELLRQAG KHLKILPHSV YNERDEPVEL CSSVECKGII GNDGRHYILD LLRTFPPDVN
     FLKLQEVKLS TELVEMGFPI EHRHKLCCLR QELLEAFVED RYVNFIRIAA VHLQQLNAKK
     PEETQSEEKK QLPAIEEAEK ENKENLNVNE TPNEKEKDTP VETKNAEAMV NAIREAQSNV
     ATSNEIQAAE VVKQACAAVG SMKEKEFDFR FNPDVFSPGI RHVDGEEGTS GSVAKQKLLV
     QDAAEFLVVK QIPAFVKEHL SHSSPPIDGQ NLTESLHSHG INVRYLGKVI KTLGQMPRMD
     YLYRIAVMEL IVRATKHIYY TYMQSTDPMH LSVAISHFLN CLLTNGPINP VVSNDEMHKK
     RGGNGGKHNK HKSSKGGKGQ QQPAINQNGG STTSSSSSAN AYDWTLVTPR SLWQQIRKES
     KAYWDWDLDC DSMDSAMNKF GIMRICLLRA FCLKVGIQVL LREYNFDSKH KPTFGDDDIV
     NVFPVVKHIS PRASDAYNFY TTGQAKIQQG LFKEGYELIS EALNLLNNVF GAMHQENGSC
     LRMLARLSYL LGDAQDALAI QQRAVIMSER VNGIDNPSTI LEYTHLSLYS FANGHVGMSL
     KLLYRARYLL VLTCGEDHPE VALIDSNISL ILHALGEYEL SLRFIEHALK LNLKYFGNKA
     MHVAVSYHLM ARTQSCMGDF RSALNNEKET YSIYKSQLGE KHEKTRDSAE CLRLLTQQAV
     LLQRKMNDIY SNGKLTSDLP PIHITPPSMG SVLEMLNTIN GILFVQISQR DIVKVRSEIE
     KRMKANTDVN EAIKSMVAAA NNNGESEVLA PQDNNKEQAA TAQQLTNGDK VAVSS
 
 
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