CLU_DROPS
ID CLU_DROPS Reviewed; 1435 AA.
AC Q291J5;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Protein clueless {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=GA21082;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CM000071; EAL25117.2; -; Genomic_DNA.
DR RefSeq; XP_001360542.2; XM_001360505.3.
DR AlphaFoldDB; Q291J5; -.
DR SMR; Q291J5; -.
DR STRING; 7237.FBpp0277597; -.
DR PRIDE; Q291J5; -.
DR EnsemblMetazoa; FBtr0279159; FBpp0277597; FBgn0081070.
DR GeneID; 4803897; -.
DR KEGG; dpo:Dpse_GA21082; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR InParanoid; Q291J5; -.
DR OMA; VSGFYVN; -.
DR Proteomes; UP000001819; Chromosome 3.
DR Bgee; FBgn0081070; Expressed in adult organism and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1435
FT /note="Protein clueless"
FT /id="PRO_0000366385"
FT DOMAIN 420..662
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1096..1129
FT /note="TPR 1"
FT REPEAT 1222..1255
FT /note="TPR 2"
FT REPEAT 1257..1290
FT /note="TPR 3"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1407..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..762
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 266
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1435 AA; 160221 MW; 7F5FE0B32A5342CC CRC64;
MALEMDSKNS NSAVTGDAAA ATTKTNKAKE NNNLAGSKKN QSQNLVNGNG TAADGPATKK
KGKKNRNKSP PVSTDEAALS NGHVEEKKPE GDGDADADAN ANVVAVKDEK AEGGDGADAA
ELDTEDIDLD ALHDAGIHVN ISCPGSELLT VQLSSMELVQ EIHQLLMDRE ESCHRTCFSL
QLDNVTLDNF AELKTIEQLE SGSTIKVVEE PYTMREARIH VRHVRDLLKN LDPADAYNGI
ECTSLTYLNT ITQGDLLDKK KTRPDSVDCT PPDYVTPGVF EPPLLPLHPN FKNAKGPQAL
KVLTTSAWNP PPGPRKLHGD LMYLYVITME EKRYHISACS RGFFINQSTD DTFNPKPDNP
SYLSHSLIDL LSHISPSFRR AFQAIQKRRT LRHAFERVAT PYQVYQWAAP NLEHTVDAIR
AEDAFSSKLG YEEHIPGQTR DWNEELQTTR ELPRKTLPER LLRERAIFKV HGDFVTAATR
GAMAVIDGNV LAINPGEDSK MQMFIWNNIF FSLGFDVRDH YKELGGDYAA YVAPRYDLHG
VRVYNAVDVE GLYTLGTVVI DYRGYRVTAQ SIIPGILERE QEQSVVYGSI DFGKTVLSHP
KYLELLRQAG KHLKILPHSV YNERDEPVEL CSSVECKGII GNDGRHYILD LLRTFPPDVN
FLKLQEVKLS TELVEMGFPI EHRHKLCCLR QELLEAFVED RYVNFIRIAA VHLQQLNAKK
PEETQSEEKK QLPAIEEAEK ENKENLNVNE TPNEKEKDTP VETKNAEAMV NAIREAQSNV
ATSNEIQAAE VVKQACAAVG SMKEKEFDFR FNPDVFSPGI RHVDGEEGTS GSVAKQKLLV
QDAAEFLVVK QIPAFVKEHL SHSSPPIDGQ NLTESLHSHG INVRYLGKVI KALGQMPRMD
YLYRIAVMEL IVRATKHIYY TYMQSTDPMH LSVAISHFLN CLLTNGPINP VVSNDEMHKK
RGGNGGKHNK HKSSKGGKGQ QQPAINQNGG STTSSSSSAN AYDWTLVTPR SLWQQIRKES
KAYWDWDLDC DSMDSAMSKF GIMRICLLRA FCLKVGIQVL LREYNFDSKH KPTFGDDDIV
NVFPVVKHIS PRASDAYNFY TTGQAKIQQG LFKEGYELIS EALNLLNNVF GAMHQENGSC
LRMLARLSYL LGDAQDALAI QQRAVIMSER VNGIDNPSTI LEYTHLSLYS FANGHVGMSL
KLLYRARYLL VLTCGEDHPE VALIDSNISL ILHALGEYEL SLRFIEHALK LNLKYFGNKA
MHVAVSYHLM ARTQSCMGDF RSALNNEKET YSIYKSQLGE KHEKTRDSAE CLRLLTQQAV
LLQRKMNDIY SNGKLTSDLP PIHITPPSMG SVLEMLNTIN GILFVQISQR DIVKVRSEIE
KRMKANTDVN EAIKSMVAAA NNNGESEVLA PQDNNKEQAA TAQQLTNGDK VAVSS
