CLU_DROVI
ID CLU_DROVI Reviewed; 1465 AA.
AC B4LQ23;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Protein clueless {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=GJ21424;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH940648; EDW60346.1; -; Genomic_DNA.
DR RefSeq; XP_002049153.1; XM_002049117.2.
DR AlphaFoldDB; B4LQ23; -.
DR SMR; B4LQ23; -.
DR STRING; 7244.FBpp0235841; -.
DR EnsemblMetazoa; FBtr0237349; FBpp0235841; FBgn0208550.
DR GeneID; 6626877; -.
DR KEGG; dvi:6626877; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR InParanoid; B4LQ23; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR PhylomeDB; B4LQ23; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0031315; C:extrinsic component of mitochondrial outer membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblMetazoa.
DR GO; GO:0072686; C:mitotic spindle; IEA:EnsemblMetazoa.
DR GO; GO:0098799; C:outer mitochondrial membrane protein complex; IEA:EnsemblMetazoa.
DR GO; GO:0003729; F:mRNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0043022; F:ribosome binding; IEA:EnsemblMetazoa.
DR GO; GO:0055059; P:asymmetric neuroblast division; IEA:EnsemblMetazoa.
DR GO; GO:0051646; P:mitochondrion localization; IEA:EnsemblMetazoa.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1465
FT /note="Protein clueless"
FT /id="PRO_0000366386"
FT DOMAIN 427..669
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1114..1147
FT /note="TPR 1"
FT REPEAT 1240..1273
FT /note="TPR 2"
FT REPEAT 1275..1308
FT /note="TPR 3"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1428..1465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1465 AA; 161824 MW; B3F6A71773E33A0D CRC64;
MALEIDAKNA AATGDAGTIG KAKAKENKNH NNNNNAPAAG EKNLVNGSSA ATKKKGKKNR
NKSPPQNAVE AEASAALSNG HSENGDAADA NANVLAEKGE GVAAGAVVGD GAEGGASAEG
AVAEGDAAAA GEDVDLDALH DIGITVNISS PGTDVLSVQL SSMELVQEIH QLLMDREETC
HRTCFSLQLD NVTLDNFAEL KTIESLEQGS TIRVVEEPYT MREARIHVRH VRDLLKNLDP
ADAYNGIDCT SLTYLNTITQ GDLLDKKRTR PDSVDCTPPD YVTPGVREPP LLPLHPNIKN
AKGPQALKVL TTSAWNPPPG PRKLHGDLMY LYVVTMEDKR FHISACSKGF YINQSTDECF
NPKPDNPSHL SHSLIDLLSH ISPSFRRAFQ AIQKRRTMRH AFERVATPYQ VYQWAAPQLE
HTVDAIRAED AFSSKLGYEE HIPGQTRDWN EELQTTRELP RKTLPERLLR ERAIFKVHGD
FVTAATRGAM AVIDGNVLAI NPGEDAKMQM FIWNNIFFSL GFDVRDHYKE LGGDHAAFVA
PRYDLHGVRV YNAVDIEGLY TLGTVVIDYR GYRVTAQSII PGILEREQEQ SVVYGSIDFG
KTVLSHPKYL ELLRQAGKHL KILPHSVLNE RDEPVELCSS VECKGIIGND GRHYILDLLR
TFPPDVNFLK LQDVQLSKEL TEMGFPIEHR HKLCCLRQEL LEAFIEDRYV TFIRIAAVHL
QQLNAKKQAA TANAEKELPA IAEKQEEPNE EQPEKTEEQP AEKEESKPTP SETKSAEAMV
NAIREAQSNV AVSNEVQAAE VVKRACAAVG SLKEKEFDFR FNPDVFSPGI RHVDGPDGGV
QSLAKQKRLV QDAAEFLVLK QIPAFIKEHM AHSSPPIDGQ SLTESLHSHG INVRYLGKVI
KMLGQMPRMD YLHRIAILEI IVRATKHIYY TYMQSTEPLH LSAAISHFLN CLLTTGPVNP
AVSSDELHKK QPRNNSGKHN KHKAAKASKP QAAAAQNGNA TAAGSGGAGA TTSGATSSNS
DWTLVTPRSL WQQIRKEVKA YWNWELDCDS IESAGAKYGL LRISLLRAFC LKVGIQVLLR
EYNFESKHKP TFGDDDIVNV FPVVKHISPR ATDAYNFYTT GQAKIQQGML KEGYELISEA
LNLLNNVFGA MHQENDSCLR MLARLSYLLG DAQDALAIQQ RAVIMSERVN GIDHPSTILE
YTHLSLYSFA NGHVGMSLKL LYRARYLLVL ICGEDHPEVA LIDSNISLIL HALGEYELSL
RFIEHALKLN LKYFGNKAMH VAVSYHLMAR IQSCMGDFRS ALNNEKETYS IYKSQLGEKH
EKTRESAECL RLLTHEAVAL QRKMNDIYSN GKLTSDLPPI HITPPSMGSV LEMLNTINGI
LFVHISQKDI VKVRSEIEKH LKTNTDENDV PDESEITSAL KTIVAAVNNN DNASETEQPK
DEASAAGTPT QLTNGSEEST ATVSS
