CLU_DROWI
ID CLU_DROWI Reviewed; 1441 AA.
AC B4MY63;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Protein clueless {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=GK22132;
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH963894; EDW77052.1; -; Genomic_DNA.
DR RefSeq; XP_002066066.1; XM_002066030.2.
DR AlphaFoldDB; B4MY63; -.
DR SMR; B4MY63; -.
DR STRING; 7260.FBpp0251275; -.
DR PRIDE; B4MY63; -.
DR EnsemblMetazoa; FBtr0252783; FBpp0251275; FBgn0224117.
DR GeneID; 6643348; -.
DR KEGG; dwi:6643348; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR InParanoid; B4MY63; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR PhylomeDB; B4MY63; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0031315; C:extrinsic component of mitochondrial outer membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblMetazoa.
DR GO; GO:0072686; C:mitotic spindle; IEA:EnsemblMetazoa.
DR GO; GO:0098799; C:outer mitochondrial membrane protein complex; IEA:EnsemblMetazoa.
DR GO; GO:0003729; F:mRNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0043022; F:ribosome binding; IEA:EnsemblMetazoa.
DR GO; GO:0055059; P:asymmetric neuroblast division; IEA:EnsemblMetazoa.
DR GO; GO:0051646; P:mitochondrion localization; IEA:EnsemblMetazoa.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1441
FT /note="Protein clueless"
FT /id="PRO_0000366387"
FT DOMAIN 427..669
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1109..1142
FT /note="TPR 1"
FT REPEAT 1235..1268
FT /note="TPR 2"
FT REPEAT 1270..1303
FT /note="TPR 3"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..765
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..1009
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1441 AA; 160067 MW; 5C78AA63C15D42EC CRC64;
MALDIDTKNS SSAATGDANT VKANNNSSAA STGNKKTENL VNGNNNSAAD GPAAKKKGKK
NRNKSPPIAT DAETTEAATT TAVTNGHEGE ALVNGDAVAP DANANVAAND ESESAEQQAA
ENAASSGELE SEDVDLDALH DVGITVNISS PGADIISVQL SSMELVQEIH QLLMDREETC
HRTCFSLQLG NNTLDNFAEL KTVENLEQGS TIKVVEDPYT MREARIHVRH VRDLLKNLDP
TDAYNGIDCT SLTYLNTITQ GDLLDKKKTR PDSVDCTPPE YVTPGVKEPP LLPLHPNIKN
AKGPQALKVL TTSAWNPPPG PRKLHGDLMY LYVVTMEEKR FHISACSKGF FINQSTDENF
NPKPDNPSHL SHSLIDLLST ISPIFRRAFQ TIQKRRTLRH AFERVATPYQ VYQWASPQLE
HTVDAIRAED AFSSKLGYEE HIPGQTRDWN EELQTTRELP RKTLPERLMR ERAIFKVHGD
FVTAATRGAM AVIDGNVLAI NPGEDSKMQM FIWNNIFFSL GFDVRDHYKE LGGDHAAFVA
PRYDLHGVRV YNAVDVEGLY TLGTVVIDYR GYRVTAQSII PGILEREQEQ SVVYGSIDFG
KTVLSHPKYL ELLRQAGKHL KILPHSVLNE RDEPVELCSS VECKGIIGND GRHYILDLLR
TFPPDVNFLK LQDVKLSKEL TEMGFPIEHR HKLCCLRQEL LEAFIEDRYV SFIRIAAVHL
QQLNAKKQDE AKEGTKEPAS ETEKESPPKA ITEKEEEESK DQPTVGETKS AEAMVNAIRE
AQSNMATSNE VQAAEVVKRA CAAVGSLKEK EFDFRFNPDV FSPGIRHVDG EEGTSSSIVK
QKRLVQDAAE FLVLKQIPTF IKEHLAHSSP PIDGQTLTES LHNNGINVRY LGKVIKMLSQ
MPRMEYLYRI ANLELIVRAT KHIYYTYMQG TEPLHLSAAI SHFLNCLLTN GPVNPAISKE
EIHKKRTNTK YNKHKSSKSS GSGSKQSGQT SNQNGTSTSP SSSTASGGTS SNVAIDWTLV
TPRSLWQQIR KEAKAYWDWD LECDAIDIAL TKYGISRISL LRGFCQKVGI QVLLREYNFE
SKHKPTFGDD DIVNVFPVVK HISPRSTDAY NFYTTGQSKI QQGLFKEGYE LISEALNLLN
NVFGAMHQEN GSCLRMLARL SYLLGDAQDA LAIQQRAVIM SERVNGIDHP STILEYTHLS
LYSFANGHVG MSLKLLYRAR YLLVLICGED HPEVALIDSN ISLILHALGE YELSLRFIEH
ALKLNLKYFG AKAMHVAVSY HLMARTQSCM GDFRSALNNE KETYTIYKSQ LGEKHEKTRD
SAECLRLLTQ QAVLLQRKMN DIYSNGKLTS DLPPIHITPP SMGSVLDMLN TINGILFVQI
SQNDIVKVRS EIEKHLKANG EESEVNDAIK SIVDASGNNN GETEALINGG EESTVTVTAT
S
