CLU_DROYA
ID CLU_DROYA Reviewed; 1451 AA.
AC B4P6P7;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Protein clueless {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=GE11763;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CM000158; EDW91974.1; -; Genomic_DNA.
DR RefSeq; XP_002092262.1; XM_002092226.2.
DR AlphaFoldDB; B4P6P7; -.
DR SMR; B4P6P7; -.
DR STRING; 7245.FBpp0256773; -.
DR EnsemblMetazoa; FBtr0258281; FBpp0256773; FBgn0229557.
DR GeneID; 6531463; -.
DR KEGG; dya:Dyak_GE11763; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR PhylomeDB; B4P6P7; -.
DR Proteomes; UP000002282; Chromosome 2R.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0031315; C:extrinsic component of mitochondrial outer membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblMetazoa.
DR GO; GO:0072686; C:mitotic spindle; IEA:EnsemblMetazoa.
DR GO; GO:0098799; C:outer mitochondrial membrane protein complex; IEA:EnsemblMetazoa.
DR GO; GO:0003729; F:mRNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0043022; F:ribosome binding; IEA:EnsemblMetazoa.
DR GO; GO:0055059; P:asymmetric neuroblast division; IEA:EnsemblMetazoa.
DR GO; GO:0051646; P:mitochondrion localization; IEA:EnsemblMetazoa.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphoprotein.
FT CHAIN 1..1451
FT /note="Protein clueless"
FT /id="PRO_0000366388"
FT DOMAIN 424..666
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1431..1451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 270
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1451 AA; 160766 MW; FB3816AF74E1714D CRC64;
MALETEAKNS NATATGDATA TKASSKAKEN NNTAGGKKNL NPIPSQQNSN QNLVNGNGTA
ADGPAGKKKG KKNRNKSPPE PTTEAVLSNG HAEKSTAEYA AEDNADADAN ANVEKPEDGG
APDAEADGED IDLDALQDVG ITVNISSPGA DVLCVQLSSM ELVQEIHQLL MDREETCHRT
CFSLQLDNAT LDNFAELKAI SNLEQGSTIK VVEEPYTMRE ARIHVRHVRD LLKNLDPADA
YNGIDCTSLT YLNTITQGDL LDKKKTRPDS VDCTPPEYVT PGVSEPPLLP LHPNVKNAKG
PQALKVLTTS AWNPPPGPRK LHGDLMYLYV VTMEEKRFHI SACSKGFYIN QSTDDTFNPK
PDNPSHLSHS LIDLLSHISP SFRRAFQTIQ KRRTMRHAFE RVATPYQVYQ WASPTLEHTV
DAIRAEDAFS SKLGYEEHIP GQTRDWNEEL QTTRELPRKT LPERLLRERA IFKVHGDFVT
AATRGAMAVI DGNVLAINPG EDPKMQMFIW NNIFFSLGFD VRDHYKELGG DAAAFVAPRY
DLHGVRVYNA VDVEGLYTLG TVVIDYRGYR VTAQSIIPGI LEREQEQSVV YGSIDFGKTV
LSHPKYLELL RQAGKHLKIL PHAVLNERDE PVELCSSVEC KGIIGNDGRH YILDLLRTFP
PDVNFLKLQD VQLSKELVDM GFPIEHRHKL CCLRQELLEA FIEDRHVSFI RIAAVHLQQL
NAKKQSEKTE GKPVPALEGA DAASKVNGAD KTDVKEEKNE ENEEKAQSTT GESKTAEAMV
NAIREAQSNV ATSNEVQAAE VVKRACAAVG SLKEKEFDFR FNPDVFSPGI RHVDGEEGTC
SSLAKQKVLV QEAAEFLVLK QIPAFIKEHM THSSPPIDGQ SLTESLHSHG INVRYLGKVI
KILGQMPRMD YLHRIAVLEL IVRATKHIYY TYMQNTEPLH LSAAISHFLN CLLTNGPVNP
AVSSEEAHKK RGNGGKHNKH KSSKGGKGQQ QQQTTGNQNG SSSGTSNGSS VSDWTLVTPR
SLWQQIRKEA KVYWDWELDC DSIETAVSKY GILRISLLRA FCLKVGIQVL LREYNFESKH
KPTFGDDDVV NVFPVVKHIS PRATDAYNFY TTGQAKIQQG MFKEGYELIS GALNLLNNVF
GALHQENGSC LRMLARLSYL LGDAQDALAI QQRAVIMSER VNGMDHPSTI LEYTHLSLYS
FANGHVGMSL KLLYRARYLM VLICGEDHPE VALIDSNISL ILHALGEYEL SLRFIEHALK
LNLKYFGDKA MPVALSYHLM ARTQSCMGDF RSALNNEKET YSFYKSQLGE NHEKTRDSAE
CLRLLTQQAV LLQRKMNDIY SSGKLTSDLP PIHITPPSMG SVLDMLNTIN GILFVKISRK
DIVKVRSEIE KHFKADSPEN EVNDAINSIV AAANNNGEAE DADPKDVKEQ AQAGTQLTNG
EKAAATEATS S
