CLU_EMENI
ID CLU_EMENI Reviewed; 1225 AA.
AC Q5B3H2; C8V9G0;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu1 {ECO:0000255|HAMAP-Rule:MF_03013}; Synonyms=tif31;
GN ORFNames=AN4908;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF76502.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAA60986.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; BN001303; CBF76502.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AACD01000084; EAA60986.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_662512.1; XM_657420.1.
DR AlphaFoldDB; Q5B3H2; -.
DR SMR; Q5B3H2; -.
DR STRING; 162425.CADANIAP00005492; -.
DR EnsemblFungi; EAA60986; EAA60986; AN4908.2.
DR GeneID; 2872707; -.
DR KEGG; ani:AN4908.2; -.
DR VEuPathDB; FungiDB:AN4908; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR InParanoid; Q5B3H2; -.
DR OrthoDB; 60958at2759; -.
DR Proteomes; UP000000560; Chromosome III.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1225
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000419437"
FT DOMAIN 281..532
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 949..982
FT /note="TPR 1"
FT REPEAT 991..1024
FT /note="TPR 2"
FT REPEAT 1033..1066
FT /note="TPR 3"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1153..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1225 AA; 135665 MW; E865423ADBE0BE28 CRC64;
MAQTNGEMEH SKESPEQITN GNNQEVVQED DGAGGLFQIS VKLPHEPYKI QVMVSSQEQV
QDVRQSIVEL PGTFQYTCFH LEFNGKRIND FVELSEVPGL QADSEIVLVE DPYTEKDARM
HVVRLRELLG AAGDRVDTIN GVNAGLSLHD SIAAEAGSEK SEKEHSLAKY DIPGSSSLKT
ILPRSEAPAP KTVKSISLSP WNPPPHHLRQ KGHLLYLQVT TNEGEQFQIT SHVSGFFVNK
CSNSRFDPFP KTIPKKGSAH SLLNLISQLS PSFDAAFKEL QESNNQKDLL TTFPFQNSIP
SSPWLVAPPA SNSLQTTKEL PRETVQDRVF RERLTSKLFA DYNEAAARGA VLVARGEVAP
LNPTEAQDAQ IFVYNNIFYS FGADGVGTFA SEGGDEAARV AVGKDVLGIK AVNQLDINGL
FTPGTIVVDY MGKRIVGQSI VPGIFKQREP GEHQIDYGGV EGKDVVATHP DFVPVFEKLS
KALRIKKHPV WDKDNQRHDL EGSVETKGLL GTDGRKYVLD LYRVTPLDVA WNEEEDGDAY
PHRMSVLRLE LVESYWRAKM SQYVKAEVER RRAAKAEEAA KKEKSSEDTE SKEEGSEEKS
EEALDQERVD ISGFSLALNP DVFSGQIPQT DEEKEQWAQD EKEVRDACDF LRSKVMPELI
QDLHDGDVGF PMDGQSLSQL LHKRGINIRY LGKLATLAKE KGSRLEALST LLVQEMVVRA
FKHITNKYLR NVPAPFAASC VAHLLNCLLG ADVNATPRAE IDSSLREIYP EGDFSFEKVT
PEALRAEIEK QVTLRYRFNL ESQWFNSLRH LQLLRDIAIK LGLQLAARDF VFTKAQAEGL
KVLPVANGVN GTGQDEGSKK KKKNKNGDSG SPARSAAAEK PIVTFTPDDI VNIVPLVKDA
SPRSSLAEEA LEAGRISLMQ NQKQLGQELI LESLSLHEQI YGILHPEVAK LYHQLSMLYY
QTDEKDAAVE LARKAVIVTE RTLGVDSADT ILSYLNLSLF EHASGNTKVA LAYIKHAMDL
WKIIFGSNHP DSITTMNNAA VMLQHLKQYS DSRKWFEASL SVCESLFGKQ SINTATILFQ
LAQALALDQD SKAAVGKMRD AYNIFLSQLG PEDRNTKEAE TWLEQLTQNA VSIAKHAKDI
QARRLRRINM GTRTTLGTQI QPQVGQSTAD VSAPSQASNS SIDSRNIDEL LKFIEGGDTS
SSRTKQKKRA AASNPKLRGS KKSSA
