CLU_KLULA
ID CLU_KLULA Reviewed; 1269 AA.
AC Q6CIN0;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013};
GN OrderedLocusNames=KLLA0F25322g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CR382126; CAG98917.1; -; Genomic_DNA.
DR RefSeq; XP_456209.1; XM_456209.1.
DR AlphaFoldDB; Q6CIN0; -.
DR SMR; Q6CIN0; -.
DR STRING; 28985.XP_456209.1; -.
DR EnsemblFungi; CAG98917; CAG98917; KLLA0_F25322g.
DR GeneID; 2895162; -.
DR KEGG; kla:KLLA0_F25322g; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR InParanoid; Q6CIN0; -.
DR OMA; VSGFYVN; -.
DR Proteomes; UP000000598; Chromosome F.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:EnsemblFungi.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1269
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366405"
FT DOMAIN 297..552
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1020..1053
FT /note="TPR 1"
FT REPEAT 1147..1180
FT /note="TPR 2"
FT REGION 958..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1211..1242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1269 AA; 143418 MW; ACA63B452EC28333 CRC64;
MSADNIEVIV KGTPSYTKSK NSDIKYQLGK ESNVSHLRTF LSFEESTKFY TSYDLIENSR
VVDDEDVLGD LAGNGSSLTF QFKPKAYNLV TAVQHIVGLR ETLGFSSELE DGISEFAISS
GSQFQDMSLE PNSEKSNGSE TTISDQEKVK FLQTCNELLE STNTDFNIAS LKTGNLLVTP
VLKSLHFSAY NPVPAFYKNK GHLLYLQAST LENETFHITT SISGFYVNKS SSVKFDPSPK
DEFEPKFNLI DLLTQVSKKF HQHVTSLRNK LSSTDSAQYV KPASCFLSKP WLVSQLPSNN
GDFMRTQLEH FNNDDERNFC DEFQAIKDLE INSSYDRLKN EKITAGLIHE FNSEAVKGAM
AIFNNELTPI DPGTTGENAV YFHKSLIFSF VADVSGTYSS IGGNEAAYAV ANQDLQIINS
LNRLGLKGIR HCLTAIIDYA GHRLLVQSPV PGLLTPVGVN IIVDEEDKEV AEPMETLISV
NYGYDDFVAT LKFDEKFHEK VCEFSKNFYL KEHKVEEVDL RISSKSKGIF GVDQRAYILD
LANTNPVDIE FVKAHYDDVK ENKYPHRQVL LRRELVERWR AEKIAASGKT LQEASEDVSF
IYNPDAYVID GVEDENVADM SKFLNDTVLT LFLEDILKGN SNIPYDGQHL TDLFHTNGVN
MRYLGKAIEF VKAKYEDQKQ ERAKYLSKIE QENKEYQDWE TGYLVKVEKL IKERQEEINK
YVQQGKEVPS KLKEQIQLDK ADLKEPVRNE GCTVEVDQFE GLIAVCELEM IARSIKHIFR
QQSKKLSSPT LVPHLVAFFL NLLFGKSYNE SVTVENLDAL FDINELEFAQ YTREQLIEEV
RVQAKLRFRY DLTSEWFDIN EKRFSKYALI RAIAQKFGIQ LINKEYFFTK EQYEKWKQAQ
DKKLRSKIVD PKQTFSINDF SLRPVIKGAE FQSLIAEELW IQGASLVNAV SVEEEEAEKK
KEESKKAAAD GEDAGSSGAT SKEEEQAKER AKKMNEALTL LGQSIAFRED IFGLVHPSLV
SSYLLLSNMY SRLGQYSQAV TFCNKAALLS ERCYGVDSFE TVRILSNLAY LEYGQGSIYN
SALVLKKVHE LLKLLAPFVH SGRVNVFNLL FQIAASTEDK KVQIKILNKL SELLLKITGS
EETLPYGQNE SRIANLYTSL DDMSHALSHI EKAKSIFSKE LGLNDQTTLT SKQWSETIKG
IITKQQQEKK LASAQQATKP ANISQKKGKK SSSSSPALTN KSVDELLQFI EGPGASKSSK
KSKKKHTKN
