CLU_LODEL
ID CLU_LODEL Reviewed; 1397 AA.
AC A5DWP3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=LELG_01780;
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC YB-4239;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH981525; EDK43601.1; -; Genomic_DNA.
DR RefSeq; XP_001526951.1; XM_001526901.1.
DR AlphaFoldDB; A5DWP3; -.
DR SMR; A5DWP3; -.
DR STRING; 379508.A5DWP3; -.
DR PRIDE; A5DWP3; -.
DR EnsemblFungi; EDK43601; EDK43601; LELG_01780.
DR GeneID; 5234473; -.
DR KEGG; lel:LELG_01780; -.
DR VEuPathDB; FungiDB:LELG_01780; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR InParanoid; A5DWP3; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1397
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366406"
FT REPEAT 30..63
FT /note="TPR 1"
FT DOMAIN 368..640
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 559..595
FT /note="TPR 2"
FT REPEAT 1167..1200
FT /note="TPR 3"
FT REPEAT 1209..1242
FT /note="TPR 4"
FT REGION 158..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1314..1397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1034
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1397 AA; 156684 MW; 00FE3775CE5F71ED CRC64;
MSNGDVVVDA DQQQAQAVVA PQQLELQIKL PSFIDQKGDL KIPSHYEETI TDLKLTLTVI
PKTRSLTNYL ILIQGEHDVE QFGEIVTFGQ IIEELALGEP ECLQIQIREK PYNLAAVYEQ
IIRLREIVGL HYVDKVSQEL GSCGGVTRFN SIKLDPVTAR GEAEKSDTNE EEQEQGKGKV
GKPNEKESGE TKETDSQPEL SREELLQLSD LVKEIEESPE SINFTQATKF DNINGKVKIP
LKSFAVSQWS PVPSFQKTKG DLLYLTVQTL ENETFHITSH FTGFFVNKCS ATTFNPALKT
NEKGRYHKHY LLYELLAQLS PSFTKTIEDN EVKLSESTEH PETYLLPNNS FLAFPWVVNA
SDLKNIPDSS RSQLMLISNG VDGSEIIKEW NNDIQAMKEL PSTNFQERLM RDKLIQKTLF
DFSKTATETA INIIKGNIAP MNPGEEPDKL IYLKNGVFYS AGTSTVDVFD KTGGEEASRY
VSSKDLAAIK IVNRHELKGI STLVTCIVDY MGKRIVCQAP VPGILDAAPP SEEEDDAGAE
QEKKEEGKAE EDEEEEIMEK VLYGLSSDSQ KILEDKSFEK PLKLLSEVFH LKPHGVKLSE
QVKSEGDLVV SKDTKGLKGT DGRKYAIDLY RTTPRDIEFI EAHFKEGEND SYPHGEALIR
HEAVNEWWKR KVSALFAAET EKLEKEGKLE KDGSKGTNSE EKSQIALPID QVSFNPDAFS
SDFESKEDRD EVREISKFIK EKLIPEFIEE CQHQLAPFDG QQLSEQLHRY GINLRYLGYI
AEQVLVKKAE YEESVEKTIK ENEELVKVRE AEKVEKDRRE AEEAEKAKER AAAQPESSSD
DKNQETIENS DAKSKENTES DDKDAEEQPV SKATYELVLA NYDSLYRLAI QEMVARASKH
VLRQIMKETP LELSAKAVAH FHNCLLGGEI NTSPEAEIDP LEASFFSQSA ISFAKLTHKD
VVAQVAKEVG SRFRFTLEEN WIEKLVHLPQ LFREIALKFG IQWKSFDYTF TKQEFEHSQR
EQKQESVVDN VEKKHSKKSK KKSPALPIEN KPTSFARSSI FIADDIVGFV PLVKDSSYKP
TLVDEIFANA RSQLLSGDKD LGMAMLAELV TIYEAIYGKV NSQTAKFYSL VAKVYQELGF
DKEAAIMGRK AVVLSERSCG FDNHDTIAAY MNSAYFELAN SQIANSLKLY LRAMQLWTST
YGKDHPALVN LLTNVADSLY YAKDYESALK LFNAALEACS HLNGQASEIA GLFHFKIANV
LVSQQKIEKS KDSFVAANEI FQKLLGPDDS MTDQTSKYIS NVAMYIEYLK ARQAQSKKSP
PPTQTVAPNA RVSASQASAK VANGNGTGSS KSKKGKKDKS TPQSDPQIAN QSVEDILKFI
EGKSKPNAKS KSKHTKA
