ID   CLU_MALGO               Reviewed;        1325 AA.
AC   A8QA64;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE   AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=MGL_3623;
OS   Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX   NCBI_TaxID=425265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4612 / CBS 7966;
RX   PubMed=18000048; DOI=10.1073/pnas.0706756104;
RA   Xu J., Saunders C.W., Hu P., Grant R.A., Boekhout T., Kuramae E.E.,
RA   Kronstad J.W., DeAngelis Y.M., Reeder N.L., Johnstone K.R., Leland M.,
RA   Fieno A.M., Begley W.M., Sun Y., Lacey M.P., Chaudhary T., Keough T.,
RA   Chu L., Sears R., Yuan B., Dawson T.L. Jr.;
RT   "Dandruff-associated Malassezia genomes reveal convergent and divergent
RT   virulence traits shared with plant and human fungal pathogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:18730-18735(2007).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC       factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; AAYY01000014; EDP41942.1; -; Genomic_DNA.
DR   RefSeq; XP_001729156.1; XM_001729104.1.
DR   AlphaFoldDB; A8QA64; -.
DR   SMR; A8QA64; -.
DR   STRING; 425265.A8QA64; -.
DR   EnsemblFungi; EDP41942; EDP41942; MGL_3623.
DR   GeneID; 5853462; -.
DR   KEGG; mgl:MGL_3623; -.
DR   VEuPathDB; FungiDB:MGL_3623; -.
DR   InParanoid; A8QA64; -.
DR   OMA; VSGFYVN; -.
DR   OrthoDB; 60958at2759; -.
DR   Proteomes; UP000008837; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS51823; CLU; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..1325
FT                   /note="Clustered mitochondria protein homolog"
FT                   /id="PRO_0000366408"
FT   DOMAIN          311..573
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REGION          893..937
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1032..1063
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1245..1325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        900..920
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1325 AA;  146808 MW;  AFE2699134B983F4 CRC64;
     MAEPESEPNA TFELELFLPG RPLLPKDVKS LGLPETPPSL KVAVTQHETL NDLRITLNDS
     PEGYWLGAFR FRRPDSHTRK GELVNEWEEL QEVFRHDAPH DRILQVSHEP YNETEVRLHI
     QRLRDLLSGT QSDPASVSVD AGATVHDAIV HANEWAHDAH MPAPPKPSWR GWPQDGTAQL
     LPALARYPRV LPKCVRGMAL SAWNPPPKSW ALRGHLLYLS IDTLEGDVLH ITASVNGFFL
     NASSSQKFQP QPHPSKALHS SSLFDLLCAA SPLFLQNFAL LFNDPVSTRD YFSALPVMNS
     LPAAPWLARE PKHESDPMRT QTAFLLTGAM SADTLDGSRD WNEELQSSRE LPRSSLAERL
     MRDRVLNRLY AEFTLAAARV VPRVAAGEVA PMNPADAPAA HMYLYNNLFV TRGTDSVDMY
     RFLGGDAAAH VAVGKDLQGV RRLGNLDIEG LSLLGTVVID WLGERWVVQT VLPGLFRQVA
     ADAAASQSDG STASHVAYGG VEGPDTIHTD PAFHKVLSVA GKSLHVAEHK MRDAQGMEHE
     LCLSVDCKGL RGTDGRMYLL DVSRHTPMDV TWLDHDMEGS VLEGTDTASY PHRLPLLRPE
     LIDAYWDMHL HEFARDKLAR QRASNEASSP STATSSQVDV SDFSLNFHPD AFAEFRTGSG
     DDARVIQPAT DESIPSIAAV RKVSEYLRKE VIVRLISDVA AGLTSAVDGI ALTNRMHARG
     INMRYLGYIA NLSQPSQRDH WDQSVVSKLG SGHEALVQAF RRVVIHEMVV RSAKHCLRTY
     LRALPLMEAA ACIAHFANCF LGTEREPSPV PKMPEVIPAS TASRSESHKP WMSLTPAKLV
     EELRIDIRKR FRFELPMFFL ETELRKPQAL RALCLKMGIQ LAVRDYEFEP EAKHAEGQAA
     APSSNATKEK TTTSSRSGLS KKGKRAFPPP PSKPLRTTTF VPEDVVCVCP LVKTSTPKSS
     LSEDAFEAGR ISFVRGEREI GTELMLESIG FYEQVYGLVH PETGKCYSKF ASFLHHYAAE
     FAIKAARKAS ADSNQGSSSD GDRIGTNDAG SADGSKTEHD DQLPEVVKEV FTLENALRFQ
     RQAVTVSERT LGLDHPETMT QYMNLAMMEQ SSANLDDALR YQERVMQLWQ LLYGRDHPDV
     VHTLSSIALM LQMRQDYEPS LRAYEASHDL AVRLFGPNSI YTGNMAHELS QALILSGDLK
     AAIQVEKEAW RIFQERLGSE DPLTKESQAL LSGLAATAVR AAKQQHAREL VQTRMPSSAR
     STRSSAHHHH HRHLHQQQQN SSSSPHPIPA LANRSIDDLV EYIQGTPGTG SSRAARKRAA
     RAKRS