位置:首页 > 蛋白库 > CLU_MOUSE
CLU_MOUSE
ID   CLU_MOUSE               Reviewed;        1315 AA.
AC   Q5SW19; A8Y5E2; Q3U014; Q3U4M5; Q3V3Q8; Q505Q6; Q6GQX1; Q6PAT1; Q8CHD9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=Cluh; Synonyms=Kiaa0664;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Bone, Dendritic cell, and Spleen;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 226-1315 (ISOFORM 1).
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 81-1315 (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=12465718; DOI=10.1093/dnares/9.5.179;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O.,
RA   Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: I.
RT   The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 9:179-188(2002).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. Specifically binds mRNAs of nuclear-
CC       encoded mitochondrial proteins in the cytoplasm and regulates transport
CC       or translation of these transcripts close to mitochondria, playing a
CC       role in mitochondrial biogenesis. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC       Cytoplasmic granule {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q5SW19-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5SW19-2; Sequence=VSP_036579, VSP_036580;
CC       Name=3;
CC         IsoId=Q5SW19-3; Sequence=VSP_036578;
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH72573.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAE20503.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAE32406.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAE32929.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAE34042.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAI24374.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAP19360.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK036540; BAE20503.1; ALT_INIT; mRNA.
DR   EMBL; AK154146; BAE32406.1; ALT_INIT; mRNA.
DR   EMBL; AK154925; BAE32929.1; ALT_INIT; mRNA.
DR   EMBL; AK157310; BAE34042.1; ALT_INIT; mRNA.
DR   EMBL; AL607024; CAI24374.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL607024; CAP19360.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC060069; AAH60069.1; -; mRNA.
DR   EMBL; BC072573; AAH72573.1; ALT_INIT; mRNA.
DR   EMBL; BC094446; AAH94446.1; -; mRNA.
DR   EMBL; AB093256; BAC41440.3; -; Transcribed_RNA.
DR   RefSeq; NP_001074627.1; NM_001081158.2.
DR   RefSeq; XP_006534416.1; XM_006534353.3. [Q5SW19-1]
DR   RefSeq; XP_006534417.1; XM_006534354.3.
DR   AlphaFoldDB; Q5SW19; -.
DR   SMR; Q5SW19; -.
DR   BioGRID; 216526; 223.
DR   IntAct; Q5SW19; 3.
DR   STRING; 10090.ENSMUSP00000090593; -.
DR   iPTMnet; Q5SW19; -.
DR   PhosphoSitePlus; Q5SW19; -.
DR   SwissPalm; Q5SW19; -.
DR   EPD; Q5SW19; -.
DR   jPOST; Q5SW19; -.
DR   MaxQB; Q5SW19; -.
DR   PaxDb; Q5SW19; -.
DR   PeptideAtlas; Q5SW19; -.
DR   PRIDE; Q5SW19; -.
DR   ProteomicsDB; 283530; -. [Q5SW19-1]
DR   ProteomicsDB; 283531; -. [Q5SW19-2]
DR   ProteomicsDB; 283532; -. [Q5SW19-3]
DR   GeneID; 74148; -.
DR   KEGG; mmu:74148; -.
DR   UCSC; uc007kca.1; mouse. [Q5SW19-1]
DR   CTD; 23277; -.
DR   MGI; MGI:1921398; Cluh.
DR   eggNOG; KOG1839; Eukaryota.
DR   InParanoid; Q5SW19; -.
DR   OrthoDB; 60958at2759; -.
DR   PhylomeDB; Q5SW19; -.
DR   TreeFam; TF300565; -.
DR   BioGRID-ORCS; 74148; 10 hits in 74 CRISPR screens.
DR   ChiTaRS; Cluh; mouse.
DR   PRO; PR:Q5SW19; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q5SW19; protein.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR   GO; GO:0048312; P:intracellular distribution of mitochondria; ISS:UniProtKB.
DR   GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.30.2280.10; -; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS51823; CLU; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasm; Phosphoprotein; Reference proteome;
KW   Repeat; TPR repeat.
FT   CHAIN           1..1315
FT                   /note="Clustered mitochondria protein homolog"
FT                   /id="PRO_0000366373"
FT   DOMAIN          335..577
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REPEAT          980..1013
FT                   /note="TPR 1"
FT   REPEAT          1022..1055
FT                   /note="TPR 2"
FT   REPEAT          1106..1139
FT                   /note="TPR 3"
FT   REPEAT          1148..1181
FT                   /note="TPR 4"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          638..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1268..1315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        638..656
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1268..1295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         279
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75153"
FT   MOD_RES         281
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75153"
FT   MOD_RES         655
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75153"
FT   MOD_RES         725
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75153"
FT   VAR_SEQ         761..811
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_036578"
FT   VAR_SEQ         762..856
FT                   /note="KDCTEYAVLPMDGATLAEVMRQRGINMRYLGKVLDLVLRSPARDQLDHIYKI
FT                   GIGELITRSAKHIFKTYLQGVELSGLSAAISHFLNCFLSSYPN -> REGLKGWVGAAE
FT                   RGCCPLVPPVPWFLDHIENLLVTSALASPSLAHWQCPISQRRRQI (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_036579"
FT   VAR_SEQ         857..1315
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_036580"
FT   CONFLICT        412
FT                   /note="E -> D (in Ref. 3; AAH72573)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        817
FT                   /note="E -> D (in Ref. 1; BAE32406)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1284
FT                   /note="A -> APE (in Ref. 1; BAE34042 and 4; BAC41440)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1315 AA;  148068 MW;  868CC53BDA8E3A65 CRC64;
     MLLNGDCSEN LKKEEGTSEP PRENGLDEGE PGDETTGQEV IVIQDTGFSV KILAPGIEPF
     SLQVSPQEMV QEIHQVLMDR EDTCHRTCFS LHLDGNMLDH FSELRSVEGL QEGSVLRVVE
     EPYTVREARI HVRHVRDLLK SLDPSDAFNG VDCNSLSFLS VFTDGDLGDS GKRKKGLEMD
     PIDCTPPEYI LPGSRERPLC PLQPQNRDWK PLQCLKVLTM SGWNPPPGNR KMHGDLMYLF
     VITAEDRQVS ITASTRGFYL NQSTAYHFNP KPASPRFLSH SLVELLNQIS PTFKKNFAVL
     QKKRVQRHPF ERIATPFQVY SWTAPQAEHA MDCVRAEDAY TSRLGYEEHI PGQTRDWNEE
     LQTTRELPRK NLPERLLRER AIFKVHSDFT AAATRGAMAV IDGNVMAINP SEETKMQMFI
     WNNIFFSLGF DVRDHYKDFG GDVAAYVAPT NDLNGVRTYN AVDVEGLYTL GTVVVDYRGY
     RVTAQSIIPG ILERDQEQSV IYGSIDFGKT VVSHPRYLEL LERTSRPLKI LRHRVLNDRD
     EEVELCSSVE CKGIIGNDGR HYILDLLRTF PPDLNFLPVP GEELPEECSR AGFPRTHRHK
     LCCLRQELVD AFVEHRYLLF MKLAALQLMQ QKASKVETTT SLENGGLPSS AETKSEDSIG
     PEAGCEEEGS SVSGLAKVKE LAETIASDDG TVDPRSREVI RNACKAVGSI SSTAFDIRFN
     PDIFSPGVRF PESCQDEVRD QKQLLKDAAA FLLSCQIPGL VKDCTEYAVL PMDGATLAEV
     MRQRGINMRY LGKVLDLVLR SPARDQLDHI YKIGIGELIT RSAKHIFKTY LQGVELSGLS
     AAISHFLNCF LSSYPNPVAH LPADELLSKK RNKRRKNRPP GAADNTAWAV MTPQELWKNI
     CHEAKNYFDF TLECDSVDQA VETYGLQKIT LLREISLKTG IQILLKEYSF DSRHKPAFTE
     EDVLNIFPVV KHVNPKASDA FHFFQSGQAK VQQGFLKEGC ELINEALNLF NNVYGAMHVE
     ICACLRLLAR LHYIMGDYAE ALSNQQKAVL MSERVMGIEH PNTIQEYMHL ALYCFASSQL
     STALSLLYRA RYLMLLVFGE DHPEMALLDN NIGLVLHGVM EYDLSLRFLE NALAVTTKYH
     GPKALKVALS HHLVARVYES KAEFRSALQH EKEGYTIYKT QLGEDHEKTK ESSEYLKCLT
     QQAVALQRTM NEIYRNGSSA NIPPLKFTAP SMTSVLEQLN VINGILFIPL SQKDLENLKA
     EVARRHQLQE ANRNRDKAEE QPMAPEPEPE PERAVEDMGS PQTAKEGPSS LNLQG
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024