CLU_NEOFI
ID CLU_NEOFI Reviewed; 1317 AA.
AC A1D6Y7;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu1 {ECO:0000255|HAMAP-Rule:MF_03013}; Synonyms=tif31;
GN ORFNames=NFIA_066450;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS027690; EAW21481.1; -; Genomic_DNA.
DR RefSeq; XP_001263378.1; XM_001263377.1.
DR AlphaFoldDB; A1D6Y7; -.
DR SMR; A1D6Y7; -.
DR STRING; 36630.CADNFIAP00005514; -.
DR EnsemblFungi; EAW21481; EAW21481; NFIA_066450.
DR GeneID; 4590014; -.
DR KEGG; nfi:NFIA_066450; -.
DR VEuPathDB; FungiDB:NFIA_066450; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR GO; GO:0051640; P:organelle localization; IEA:UniProt.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1317
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366409"
FT DOMAIN 382..626
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1040..1073
FT /note="TPR 1"
FT REPEAT 1082..1115
FT /note="TPR 2"
FT REPEAT 1124..1157
FT /note="TPR 3"
FT REGION 669..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..966
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1317 AA; 146571 MW; 26B17AA68EB6821D CRC64;
MAQTNGDMEH SKGWSGHFAD FSTAQFRRPR SVCSSDETNG SFFLLQRLPK PNQSNSPPMV
NRLKDSRKRR AAVVCRIRDT RDGWFSALVL SSLTSSVIGL FQISVKLPHE PYKIQVMVSS
QEQVQDVRQS IVELPGTFQY TCFHLEFNGK RINDFVELSE VEGLKADSEI VLVEDPYTEK
EARMHMVRIR DLVGAAGDRS DNLHGLNAGL SLHDAVTAEA AADDVKEHSL SKYDITASPS
LETILPRVEA PLPKTVKSIS LSAWNPPPYH LRQKGHLLYL QVTTNEGEQF QITSHVSGFY
VNKCSNHKFD PLPRTTPKKV SAHSLLTLIS KLSPSFNSAF EALQESNNKK DLLTTFPFQN
AIPNSPWLVT PPSSNPNSHQ ADITRSQESY LVSGVDNAET LRDWNEEFQT TRELPRETVQ
DRVFRERLTS KLFADYNEAA ARGAVLVARG EVAPLNPTED RDAQIFVYNN IFYSFGADGV
GTFVSEGGDE AARVAVGKDV LGIKAVNQLD INGLFTPGTV VVDYLGKRIV GQSIVPGIFK
QREPGEHQID YGGVEGKDVV ATHPDFVSVF EKMSKALRIK KHPVWDKEGK RHELEGSVET
KGLLGTDGRK YVLDLYRVTP LDVTWQEEPG SEDYPHRMSV LRLELVEAYW RSKMSQYVKA
EVERRRAAKA QEEAANKEQS SEVTESKEQE SEEKAEEALD QERVDISGFQ LALNPDVCSG
QVPQTEEEKK QWAEDEKEVR DACEFLRSKV IPELIQDLHD GDVGFPMDGQ SLSQLLHKRG
INIRYLGKLA QLSKEKGSRL EALTTLLVQE MIARAFKHIA NRYLRNVPAP FVASCVAHLL
NCLLGADVNP NPSAEIDASL REIYPEGDFS FEKVTPETLR AEVEKQVTVR YRYTLEAEWF
ASLRHLQVLR DIAIKLGLQL GARDYAFTKA QLPAKVPVAN GVNGASHDEG KKKKKKGGDS
KSPSRAVVEE KPVISIVPDD IVNVVPLVKD ASPRSSLAEE ALEAGRISLM QNQKQLGQEL
ILESLSLHEQ IYGILHPEVA KLYHQLSMLY YQTDEKEAAV ELARKAVIVT ERTLGVDSAD
TILAYLNLSL FEHASGNTKA ALVYIKHAMD LWKIIYGSNH PDSITTMNNA AVMLQHLKQY
SDSRKWFEAS LAVCESLFGK QSINTATILF QLAQALALDQ DSKGAVGKMR DAYNIFLNQL
GPNDRNTKEA ETWLEQLTQN AVSIAKHAKD IQARRLRRIN MNPRVTTLGT KVQPQVGQTA
PEASGAKGAA NASMDSRSID ELLKFIEGGD ATSSRSKQKK RAAASNPKLR GSKKSSA
