ID   CLU_NEUCR               Reviewed;        1282 AA.
AC   Q7RY84;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 3.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE   AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=clu1 {ECO:0000255|HAMAP-Rule:MF_03013}; Synonyms=tif31;
GN   ORFNames=NCU00021, NCU20005;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC       factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; CM002238; EAA27772.3; -; Genomic_DNA.
DR   RefSeq; XP_957008.3; XM_951915.3.
DR   AlphaFoldDB; Q7RY84; -.
DR   SMR; Q7RY84; -.
DR   STRING; 5141.EFNCRP00000000108; -.
DR   EnsemblFungi; EAA27772; EAA27772; NCU00021.
DR   GeneID; 3873146; -.
DR   KEGG; ncr:NCU00021; -.
DR   VEuPathDB; FungiDB:NCU00021; -.
DR   HOGENOM; CLU_003256_2_0_1; -.
DR   InParanoid; Q7RY84; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS51823; CLU; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1282
FT                   /note="Clustered mitochondria protein homolog"
FT                   /id="PRO_0000366410"
FT   DOMAIN          331..575
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REPEAT          1021..1054
FT                   /note="TPR 1"
FT   REPEAT          1063..1096
FT                   /note="TPR 2"
FT   REPEAT          1105..1138
FT                   /note="TPR 3"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          624..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          913..945
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1257..1282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          623..650
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   COMPBIAS        26..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1282 AA;  142559 MW;  9075DE91D56E3F15 CRC64;
     MADASQATTP AAEGNPVPEV PETQTPPADV NGTTEQEQTE EGAEQALEDQ PFVVTIVLPN
     TTETLDIPVS PMEQIHEIRQ SIIEHPIAIE FSCFHLEFNG KKINDFIQVS DVEGLEHGAQ
     LHLVEDPYTE KEARIHLIRI RELIGASGDR TDTVHGVLAG VSVHDDIVVE NPDAPEAEIK
     EYDFQAPADL AILLPKETGP APKSIKSISL SPWNPPPAYW RQKGHLLYLV IQTNEGEQHH
     VTAHVGGFFV NRCSNAKFDP LPKPAPKDCA SHSLFTLLKK LSPSFEESFK KFQEFSSQKD
     PLATFQVGNT IPSAPWLVPS INSSLIAHEA DNTRSQETYL LGGAENVDSL RDWNEEFQSA
     KELPKETIQD RVFRERLLAK LFADYTDAAA RGAVLVARGE VAPLNPTEDK DAQIFVYNNI
     FFSFGADGVG TFTSEGGDEA ARVATGKDVL GVKLVNQLDI DGLYTPGTVV IDYLGKRIVG
     QSIVPGIFKQ PEAGENQIHY GAVDGKDIVA ADERFAPSFE KLATALRVKK HAVWDKENKR
     HDLEASVEMK GLLGTDGRKY VLDLYRITPL DIAWMEESGP EGSEYPHRMT VLRPELVEAL
     AKQKTREYVQ AELLKRGIIK KPEEKKEGEE ATEEAKTEEI KTEEAEKSEE PKAEETEKTE
     EASESTEVAE KKDEEAAKED ERIDISNFKF ALNPDVFSGQ VPQTEEEKAE MAQDEQDVRD
     ACTYLRDSVI PALLNDLKES DISFPMDGRS LTRLLHRRGI NMRYLGKLAT LSEGTRVECF
     RQLCVREMIA RAFKHVAAKY LRYLPLPLTS ACLAHLLNCF LGFGLNSSPV AEVDEELRKV
     FSDADYSFEQ VTPENLREAM QQEILHRFRF TLEDGWYNQL QHVQMLREVS QKLGVQIQNK
     KYAFVATEGE AEPVAEKPVA PAPAPVEDGN KKKKKKKAAR ETSPVAAAPV ATVPHTFSPD
     DFVNVVPIVK DSTPRSALAE EALEAGRLSI YQNQKKLGED LLLESLSLHE QIYGLVHPEV
     AQMYHTLSQL YYQLGQKDAA VELSRKAAIV AERTVGLDSS ETVLNYLNLS LFLHQRGDSK
     EALLYARHAL DLWKVIYGPD HPDTITTMNN YAVMLQSIKA YHESRRWFEE SLRVCNKVFG
     EQTVHSATLL FQLAQALALD QDAKKAVDRM RESYNIFKTL LGPEDKNTKE AEHWLTQLTH
     NAVSVAKATK ELQARRAKGS LGFSPRNATA GAAGIGSVVP SAVGVDNRNI DELVKFVENS
     EKKKGGKKSK GPSNPKKRGG KA