CLU_PICGU
ID CLU_PICGU Reviewed; 1271 AA.
AC A5DLU8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=PGUG_04249;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH408159; EDK40151.2; -; Genomic_DNA.
DR RefSeq; XP_001483520.1; XM_001483470.1.
DR AlphaFoldDB; A5DLU8; -.
DR SMR; A5DLU8; -.
DR STRING; 4929.XP_001483520.1; -.
DR EnsemblFungi; EDK40151; EDK40151; PGUG_04249.
DR GeneID; 5125167; -.
DR KEGG; pgu:PGUG_04249; -.
DR VEuPathDB; FungiDB:PGUG_04249; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR InParanoid; A5DLU8; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1271
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366412"
FT REPEAT 104..138
FT /note="TPR 1"
FT DOMAIN 329..580
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 502..535
FT /note="TPR 2"
FT REPEAT 1067..1100
FT /note="TPR 3"
FT REPEAT 1109..1142
FT /note="TPR 4"
FT REPEAT 1151..1184
FT /note="TPR 5"
FT REGION 729..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1271 AA; 143586 MW; 7317A16CB52AADB7 CRC64;
MTEDNAEGQE TALSSQNLVS VEITLPKDVS GASKPLTVKM AESDTISDLT STLGLLSSMR
DLTNYYVFYR NTNISETFDE LCPISEVISA LRVESQPNVK LELRHKPYTL AAVYEHLNKF
REVIGLHFID RRAFELGELS GVGKFDQLQL SQVPDQKEDE KEKVDLGEDD KASISSICDR
ILDETKLDLS EYGKFYDIYS DLQVPIKSLT ISQWSPVSPK EAVRGDLLYL TLQTLENDTY
HITCHLSGFF VNSCSTVNFN PARKPSHEPK FLFFDLVSSL SPAFAKTIAR NEEILANSSR
YAESYLIPSH TSGSYPWLVD TSAISRKPDQ SRPQLSILNN GVDGSDNVKD WNEDFQAIRE
LPSGTVNERI LRERLAIKLV SEFTKQATET AVNIIKGNLT PMNPNESVEQ HIYMRNGIFY
SSGVNATGAF DETGGNEAAR YAAAKDLAGV KLLNRIDAKG IYHLATCVVD YMGRRIVCQA
PVPGILNDPI VESDEAPADK VCYGLSTDGT KVYSDSQFHE ALKPIAEAFH MKPHKVTLPN
GFKTKEDIAL SKDSKGIRGT DGRNYVIDLY RSTPLDIDFI EKHWRPEHSD SYPHRETVLR
HEAVEEWWRR RALAIFKSET ERLEAEQGAK KNEGESEKPQ ILLDAQKVSF NPDAFTHDEV
DEEDKEVVRE MSLFVTKQLI EEFVEESKKQ LCPFDGSHLS SLLHKAGINL RYLGLIATRA
QESLEAFEQE EKSKIEDNEK AIEEEKKEEK TEKKEEKEEK ADEEKSENEE DKTKPEEPSK
GVFDPIKANL NSVRLLAIQE MIARAVKHIF RSFAHTLSSY LLPYFVAHFH NCLLGSQVSS
KPEISIDETL TAFADPDALR FITLDHQQVV SMVEEEVLLR FRFELPENWI NAVSPITMMR
EISHKFGIQW KTQGYAFTAE GFKEFQQSTE NIIVHKQKSS KKSKKRSSPS VEEVFKRKTI
FVADDIISFT PSVKSSSYKA TLLDEIFEAA RGKIAAEEKD SGVTLLNELV SIYEQIYGVV
HPETSNFYSV LSQFYSDLGF TTEASEVARK ACVLFERTAG FDSFETISSY INSAYFEAAN
SSYVNAFKLY EKALGDWDFV FGSHHPSSVT TLTNLAEILA QLKITDKANR LFSAALELSE
KINGEDSQIT AMIHYRFAGT LVNENRFDEA LGHFEKAHTT FSRHIDPNDR LTKDCSNYVA
NLKTYIAYMK QQAKDKNKPK KVKAPPVPPQ ATTKKSKNKS KMAQTQISKL HLNSSTRFSS
SSRVKPRLKK K
