ID   CLU_PICST               Reviewed;        1242 AA.
AC   A3GG12;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE   AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=PICST_80259;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC       factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; AAVQ01000001; EAZ63854.2; -; Genomic_DNA.
DR   RefSeq; XP_001387877.2; XM_001387840.1.
DR   AlphaFoldDB; A3GG12; -.
DR   SMR; A3GG12; -.
DR   STRING; 4924.XP_001387877.2; -.
DR   PRIDE; A3GG12; -.
DR   EnsemblFungi; EAZ63854; EAZ63854; PICST_80259.
DR   GeneID; 4851211; -.
DR   KEGG; pic:PICST_80259; -.
DR   eggNOG; KOG1839; Eukaryota.
DR   HOGENOM; CLU_003256_2_0_1; -.
DR   InParanoid; A3GG12; -.
DR   OMA; VSGFYVN; -.
DR   OrthoDB; 60958at2759; -.
DR   Proteomes; UP000002258; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 2.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS51823; CLU; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1242
FT                   /note="Clustered mitochondria protein homolog"
FT                   /id="PRO_0000366413"
FT   REPEAT          31..64
FT                   /note="TPR 1"
FT   REPEAT          109..143
FT                   /note="TPR 2"
FT   DOMAIN          359..606
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REPEAT          528..561
FT                   /note="TPR 3"
FT   REPEAT          947..980
FT                   /note="TPR 4"
FT   REPEAT          1073..1106
FT                   /note="TPR 5"
FT   REPEAT          1115..1148
FT                   /note="TPR 6"
FT   REPEAT          1150..1179
FT                   /note="TPR 7"
FT   REGION          158..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1189..1214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1242 AA;  139119 MW;  5C56722CF6E5C65D CRC64;
     MSGETPVKPV EVDNDVEALE SAKELSLKID LPACLNAGDS LSIPSNYDET INDLKQALSL
     LPLSRSLTNY TIYINGTNVS DSVDDLTTFS QLFELFQWDS VDLLKVTIKE RAYTLAAVYE
     QISRFREIIG LHYVDRMAED LGVASGVSRL NELTLNAVKE RENQEEKDRN EKSEKDEKDE
     KSEETEESFV LNEEDIKSLK ISAEDLSSTI DIDLAATAAS FNNIHTKIKL PIKSLTISQW
     SPVPAFQKNK GDLLYLTLQT LENETFNITC HFSGFFVNRS STVNFNPEVK VNEKGQVSKN
     YLLVNLVDSL SPSFSKVLEE NELSLSTSSE HPETYLLPNN SFLATPWYID TVHAKNYPDV
     SRSQLPLILN GVDGSDYVKD WNEDFQSVRE LPNTNIQERI LREKLIQKAL FDFTKTATDT
     SVNIIKGNLT PMNPNEEEGK HIYLKNGIFY ASDATSVEVF EATGAEEAAR YVASKDLAGV
     KVLNKADVPG VNNLVTCIVD YLGKRIVCQA PVPGIFNAAA EGEEEKVVYG LSTDGSTISQ
     DKSFEEPLKQ IAEVFHLKPH TVEVSDEIKS ESELLVSKDT KGIKGTDSRK YVIDLYRTTP
     RDIQFTEAHF DASNDTSYPH GESLLRHEAV AEWWKRKVSA LFKAETEKLE KEGKMESKDG
     EKPQIVLPTD QVVFNPDAFS FDSESDEDRE VVRNLSKFVK EKLIEEFLTE FPSQVAPFDG
     QQLTSILHRQ GINMRYLDEQ TKATYEPTLA NYDALYRVTV QEMIARAAKH LLRKLSADVP
     VNLFASFVAH FHNCLLGAAV NAQPAVEIEE LYRSFYPESA FNFTKLNSDQ VIALITKEVF
     LRFRYALPED WSSVLIHPIP LMREIALKFG IQWKAQKYVF TAQEFAAYKE KFATTSKQVE
     TAKSKKKGKK IQVVTEVVSE RDSIFVADDI VNFVPIVKDS SYKASLIDEI FQSARSHIAS
     GEKDVGLSIF NELVAIQEQI YGRVNSETAR FYTLLAQVYS ELGYQSQAAF VSRKAIILSE
     RTTGFDSYDT ITAYLNSGFY EAANFDLINS VSLYNQAVAT WTSVYGKGHP TLINTLTNIA
     ENYSRASQNE SAIKLLESAL EFSKLANGEV SEITGIVTFR LANCLINTSK FDQSLELYRA
     CEATFEKVLG PDDALTKQAS KYVSSIETYV KELAQQAVAS GNSKIKVKSQ TETVKNGKKN
     GKKSAIPQPD PEIASKSIDD ILQFIEGNNP KKSSKKSKKS KK