CLU_SCHPO
ID CLU_SCHPO Reviewed; 1173 AA.
AC O59742;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2003, sequence version 3.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu1 {ECO:0000255|HAMAP-Rule:MF_03013}; Synonyms=tif31;
GN ORFNames=SPBC530.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CU329671; CAA19172.3; -; Genomic_DNA.
DR PIR; T40522; T40522.
DR RefSeq; NP_595319.2; NM_001021226.2.
DR AlphaFoldDB; O59742; -.
DR SMR; O59742; -.
DR BioGRID; 277421; 12.
DR STRING; 4896.SPBC530.06c.1; -.
DR PaxDb; O59742; -.
DR EnsemblFungi; SPBC530.06c.1; SPBC530.06c.1:pep; SPBC530.06c.
DR GeneID; 2540905; -.
DR KEGG; spo:SPBC530.06c; -.
DR PomBase; SPBC530.06c; clu1.
DR VEuPathDB; FungiDB:SPBC530.06c; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR InParanoid; O59742; -.
DR OMA; VSGFYVN; -.
DR PhylomeDB; O59742; -.
DR PRO; PR:O59742; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SMART; SM00028; TPR; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1173
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000123556"
FT DOMAIN 316..565
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 984..1017
FT /note="TPR"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 132313 MW; C206D191C84CB1BD CRC64;
MSTIDLPTSS LPGSSGDPSG TEMSHSDVDV SVDIDVIFPD HTQTLSFSLL LSNTIHDVRQ
VILELMLAPP HTCFHLEYKR EKLHSFLEIG QIPHLKLSKT RKIVLEVVLD PYTERESKYH
IYTLLEFLSR KLPSSSTSPG IRAGFCIFPS LNIPSGENLQ IKSSSSLEEI NKIPENIVTQ
SLSYTNLLKK FETSPNPSNN GCFRSLALSG WNPVPAEFVI QGHLLYLTVL TIEGKTYNIT
SHVSGFYVNN CTSTKFDPSP CDDLQSHSLV LLLEQLSPLF KERLHLSLND YKSGDAIAQA
SITGTLPQAP WITFPVPHRA DLSRTQKSEL FPYIENQGNL RDWNEEIQST REMDHEDVQD
RVLRERLTVK TLQDFTDMAV EGAIDMVNGN IPSLNPLEPT ASQMFVHNNI FFSYGRDSVG
IFSTKGGDSA AYSAVGKDIL AIRLLNQFDL SNPSLLGTCV VDYAGHRVVA QTIVPGIFKQ
LENGSSHLIY GKVEGESDFR FDESFEGELS RISDLLHIKK HFFVDGKEKS FPLYTSMDAK
ALKGSDGRTY LMDLYSLFPL DAQFLEVISD EKNEEFPAYP HKLVHVRPEL VQLFYEMKLQ
AFVNANHNAP KKKNLNDSLK SVELEGNGIK LSSEKGKNNV NKVRNDNARF DCGFNPDCFR
SDYIFPPDNK ELYDKDIENS YALSQYLHAE VIPNFVKSLS EPSSFLPIDG VALCRAMHRS
GINIRYLGEI ANIILQKSPN NVILLKLVTS EIFIRSIKHV FRNFLAVVPQ VLRSHLLSHL
LNNLFTVYGY VEPTKPLINE NIANLFFQAT QVIYSINSTS LYSSIKKEAS SRFRFNLTDD
LLHSLNPICI LRGTCLRLGI QISCKDYFSN KSDDKICEEH AVPNGSTKFT GKKGNKKKRN
LGKSQNTTNR QVESEQINIF RPKDILNLMP VIKTCIPYSG LAQESLEACK ACLLQGNKEL
CYNLLNESLS LHEQIYGVLH TEVARAYCQL AMIYHQLEKK EEAVELARKA VIVCERFLGF
DSSETSLAYM NLSLYEFSQK NEMQAVMHMQ HALKLWYLVF GPDHPNTINS FTNLSLMLHG
SEKFIQSQKC LQIAVDLSDK IFGKTTPTAS LYLQLAQLMV LNKDSRSALH AVRVAYDILK
ETLGPDHQNT KEAEHWLSEF TALAVNQERQ SRT
