CLU_SCLS1
ID CLU_SCLS1 Reviewed; 1311 AA.
AC A7ENU3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu1 {ECO:0000255|HAMAP-Rule:MF_03013}; Synonyms=tif31;
GN ORFNames=SS1G_06992;
OS Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS (Whetzelinia sclerotiorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Sclerotinia.
OX NCBI_TaxID=665079;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18683 / 1980 / Ss-1;
RX PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH476629; EDO04509.1; -; Genomic_DNA.
DR RefSeq; XP_001591546.1; XM_001591496.1.
DR AlphaFoldDB; A7ENU3; -.
DR SMR; A7ENU3; -.
DR STRING; 665079.A7ENU3; -.
DR EnsemblFungi; EDO04509; EDO04509; SS1G_06992.
DR GeneID; 5487697; -.
DR KEGG; ssl:SS1G_06992; -.
DR VEuPathDB; FungiDB:sscle_06g052630; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR InParanoid; A7ENU3; -.
DR OMA; VSGFYVN; -.
DR Proteomes; UP000001312; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF05303; DUF727; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1311
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366414"
FT DOMAIN 335..579
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1034..1067
FT /note="TPR 1"
FT REPEAT 1076..1109
FT /note="TPR 2"
FT REPEAT 1118..1151
FT /note="TPR 3"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1236..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1239..1253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1311 AA; 144179 MW; D565C1295CF077AA CRC64;
MAATNEVIPT SENPSDVSGS SQKLATEETA LANGVDHEEE DSGEAGGEVF QLTVVLPREP
HKIPIIVSSQ EAIHDVRQSI IELPGTFQYS CFHLEHKGER INDFVQISEV PGLTADSEIH
LVEDPYTEKE ARIHIVRVRE LIGAAGDRTD TLNGIISGVS LLDSVTSAES TQNGTSTAPS
HPMVGFDFQA SGTLSTLLPK AQEPGPKTIK SISVSPWNPP PYHLRQKGHL LYLQVTTNEG
EQFQITSHVS GFYVNKSSTG KFDPSPKSAP KAHSAHSLLA LLGDLSPSFE DSFKRLQEYN
NTKEPLATFQ ITNATPSNPW IVPSASAPLV AHQADITRTQ ENYLIAGIEN SETLRDWNEE
FQSTRELPKE TVQDRVFRER LTSKLFADYN DAAARGAILV ARGEIAPLNP TEGKDAQIFV
YNNVFFSFGA DGVGTFASEG GDEAARAAVG KDVMGVRMVN QLDIDGLFTP GTVVVDYLGK
RIVGQSIVPG IFKQRDPGEN QIDYGAVDGK DIVASDEKFV SVFEKLSKAL KVKKHAVWDK
DGKRHDLEGS IETKGLLGTD GRKYVLDLYR VTPLDITWME EVGTALDSPK EADVASESAY
PHRMTVIRPE LVEAYWKVKM REWVNGELER KRQAQKTIEP TAEEKEPGAV AEASEASKSD
EPTENGELAK KADESDKDAE PSKPAADQER IDIGDFKFAL NPDAFSGQQP QTDEEKAEFA
EDEQQVRLVC EFLRKTVLPE LVNDLKEGDV GFPMDGQSLS RLLHKRGINI RYLGQVATLA
DGKRLESLRI LAVQEMVSRA FKHVAGNYLR YLPIPLTSSC IAHLLNCLLG TDLNATPKPD
VDEAMAALYP DADLKFKEVS PESLKRDIEA QILRRFRYTL DSTWTAAIKH LQLLREVSLK
LGIQLEMKPY HFTKQSQTEA AAAPPTTNGE ATKDAAPTGK STNGKKKKKN AREGSPASIT
SVNASSPVTF NPDDILNTVP VIKEASPRSS LAEEALEAGR ISLLQDQKKL GQELLLESLS
LHEQIYGILH PEVARVYNSL SMLYYQLDEK EAAMELARKA VIVSERTLGV DNAETLLNYL
NLGLIAHASG ETKLALTYIK HALDLWKVVY GPNHPDSITT INNAAVMLQH LKEYHDSRTW
FEASLKICEE VYGKHSINAA TLLFQLAQAL ALDQDSKSAV NRMRESYNIF LTELGAEDKN
TKEAEKWLEQ LTQNAVSIAK HAKDVQARRN RAGIRVSPRV TLGQTQLQPQ VGQTAEAAAG
RDSRSSRGLD SRSIDELLKF IEGSDQANKN KKRPGRSNPK RRGGAAAAAG K
