ID   CLU_VANPO               Reviewed;        1273 AA.
AC   A7TQT8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE   AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=Kpol_460p22;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC       factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; DS480463; EDO15387.1; -; Genomic_DNA.
DR   RefSeq; XP_001643245.1; XM_001643195.1.
DR   AlphaFoldDB; A7TQT8; -.
DR   SMR; A7TQT8; -.
DR   STRING; 436907.A7TQT8; -.
DR   EnsemblFungi; EDO15387; EDO15387; Kpol_460p22.
DR   GeneID; 5543458; -.
DR   KEGG; vpo:Kpol_460p22; -.
DR   eggNOG; KOG1839; Eukaryota.
DR   HOGENOM; CLU_003256_2_0_1; -.
DR   InParanoid; A7TQT8; -.
DR   OMA; VSGFYVN; -.
DR   OrthoDB; 60958at2759; -.
DR   PhylomeDB; A7TQT8; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS51823; CLU; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1273
FT                   /note="Clustered mitochondria protein homolog"
FT                   /id="PRO_0000366416"
FT   DOMAIN          344..599
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REPEAT          981..1013
FT                   /note="TPR 1"
FT   REPEAT          1022..1055
FT                   /note="TPR 2"
FT   REPEAT          1151..1184
FT                   /note="TPR 3"
FT   REGION          1217..1242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1254..1273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1217..1231
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1273 AA;  144521 MW;  F3F6AABEB54F73B4 CRC64;
     MSETGKNSTA ELSAVKVTVK LPESIVHHRS HQKKQQSHNV KETNELSFQF PRETRVQTIL
     DVLSYAQATK YLTNFKLKTV HQILNPEQSI NEIINDEKSN HLNLSIELCP YNTREIVRHV
     LTLRDFIGFA LETEDGISEF SISTGSKFSN IPFMDVKEKQ EEIEEIPRDD NKNLPKKNVL
     KVSQEEKDNF SKEVHSILDS FKYSNSNLKS AYSTISNIVT PCLNSLNLSA FNPVPAFFKT
     KGHILYLHIV TLEGESFHVT AVPSGFYINK SSSNKFDPSM KDVEGITQQD SIKYNLYDLI
     ALHSKKFHSH VEALEKKLAA YQSIEYVKPL TTFLHKPWLV SSLPANNADY SRMQLDSSQY
     ESERNFNDEF QAIRELPTPT VQESIQSERL LSRISHEFTT AAVKGAMSIF YGEMLPLNPE
     SDDQIFLRDN IFYSYVMDAN GSYDGKGGND AAFAASNQDL KTIQILKNLK MKDVYYLLTT
     IIDFGGKRIL AQTPVPGLLS NMGADVITDA DSGEQMIVDK KSEVSVVYGL DEESGKVLAN
     DQFDKSVSEE FSKYLHLKSH DVEGSKISFS YQSKGILGSD KRNYIIDLAN TYPLDVKFAK
     EHFDNAEESK RYPHRQTLLR PELVEKWWNS KVQAEGIEIN KAYDEAKFTY NPDAYQVEGV
     EDVNIQDMSS YLVETVLPSV IEDYATGNVS VPYDGEHLVD TLHINGINVR YLGKLAILAK
     EKLQLQEEVH EKRLKEIEIS NKDYEEWEAS YLKKIEKMII ERQEKVNKLV QEGKEVPKEL
     TEELKLNEDD IRKPTDDAPA VVNTDELLPL IKVTEIEIFA RTMKHILRKY TKDLPVVAIP
     SMIAFVLNLL FGQKYNEVPK PESVDSFYDV DTYEFSKLTR DGLIKEIQLV SELRFRYELA
     ADFVDQFSDA PFILIRSIAR KSGIQFLNKD YFFTKDQFEE FKLSQDKKVR GKLVAPANTF
     TVSDLNMIPR IKDIDYSSVL SDQKWAEGSM LLNEDQNAAL TLFAQAIAIK EEVNGVLHKD
     VAEKYLTLST VYSKLGLTPE AVAFCRKSCA IYERVSGIDS FEMLRSLSNL ALLEFANESP
     YNSALVFKRI VETLESLKIT EKIHHPAALN AFNQLEQMSL GVENTKLTVE LCKQFRSLIV
     SLDGNDTLAY ATLESRIGNL YASINDFHNA MEHISKTPRI FTRELGTNHQ ITAQSRQWVN
     GLSNLMKDAQ QKKKLAAEQA SVNSGSRKKN VNQKADAPKA ELAEKSVDEL LDFIEGGSTE
     KSKKKSSKKK GKK