ID   CLU_XENTR               Reviewed;        1296 AA.
AC   Q0IHW8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN   Name=cluh {ECO:0000255|HAMAP-Rule:MF_03013};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. Specifically binds mRNAs of nuclear-
CC       encoded mitochondrial proteins in the cytoplasm and regulates transport
CC       or translation of these transcripts close to mitochondria, playing a
CC       role in mitochondrial biogenesis. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC       Cytoplasmic granule {ECO:0000255|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC       Rule:MF_03013}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC122932; AAI22933.1; -; mRNA.
DR   RefSeq; NP_001072577.1; NM_001079109.2.
DR   AlphaFoldDB; Q0IHW8; -.
DR   SMR; Q0IHW8; -.
DR   GeneID; 780032; -.
DR   KEGG; xtr:780032; -.
DR   CTD; 23277; -.
DR   Xenbase; XB-GENE-5874446; cluh.
DR   eggNOG; KOG1839; Eukaryota.
DR   InParanoid; Q0IHW8; -.
DR   OrthoDB; 60958at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR   GO; GO:0048312; P:intracellular distribution of mitochondria; ISS:UniProtKB.
DR   GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 1.25.40.10; -; 2.
DR   Gene3D; 3.30.2280.10; -; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601; PTHR12601; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   SUPFAM; SSF103107; SSF103107; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS51823; CLU; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..1296
FT                   /note="Clustered mitochondria protein homolog"
FT                   /id="PRO_0000366375"
FT   DOMAIN          333..575
FT                   /note="Clu"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT   REPEAT          970..1003
FT                   /note="TPR 1"
FT   REPEAT          1012..1045
FT                   /note="TPR 2"
FT   REPEAT          1096..1129
FT                   /note="TPR 3"
FT   REPEAT          1138..1171
FT                   /note="TPR 4"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1261..1296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          662..689
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   COILED          1242..1274
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
FT   COMPBIAS        10..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1261..1278
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1279..1296
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1296 AA;  146787 MW;  59F4DC7E1D65CCC1 CRC64;
     MTLMNGDGAH EHQAEAEPKQ NGHEMGDQTE EGNEQEVIVI QDTGFTVKVQ VPGVETFSIQ
     VSPQEMVQEI HQVLMDREDT CHRTCFSLQL DGNVLDNFAE LKTIEGFQEG SVLKVVEEPY
     TVREARIHVR HIRDLLKSLD PSDAFNGVDC NSLSFLSVFT DGDLGDSGKK KKKGNELEQI
     DCTPPEYILP GSKERPLSPL QPQNKDWKPL QCLKVFTMSG WNPPPGNRKM HGDLMYLYVI
     TMEDRHVSIT ASTRGFYLNQ STAYNFNPKP ANPSFLSHSL VELLNQVSPT FKKNFAALQK
     KRVQRHPFER IATPFQLYSW TAPQVEHAMD CVRAEDAYTS RLGYEEHIPG QTRDWNEELQ
     TTRELTRKNL PERLLRERAI FKVHSDFTAA ATRGAMAVID GNVMAINPSE ETKMQMFIWN
     NIFFSLGFDV RDHYKDFGGD SAAYVSPTND LNGVRAYNAV DVEGLYTLGT VVVDYRGYRV
     TAQSIIPGIL EREQEQSVIY GSIDFGKTVV SHPKYLELLE KTSRPLKIQK HTVLNDKDEE
     VELCSSVECK GIIGNDGRHY ILDLLRTFPP DLNFLPVEGE TMPEECTKMG FPKEHRHKLC
     CLRQELVDAF VEHRYLLFMK LAAMHLMQQK ASIKDVLGTE ASTASEQLEG NGPSEEKEDL
     DLDGEAQLKQ LEETMAAHKE TVDTRSKEVI LKACQAVGSI SNTSFDIRFN PDIFSPGVRF
     PNESQEEVQN QKQLLKDAAA FVLTCQIPCL IKDCLDHSVV PMDGTTLAEA MHQRGINMRY
     LGKVIDVVRK FPVPSQLDHI YKILISEVIT RSAKHIFKTY LQGVELSALS AAISHFLNCF
     LSSFPNSVAH LQSDELVSKK KSKKRRNRNL GNTDNTAWAN TSPQELWKNI CSEAKSYFDF
     NLECENVDQA MEVYNLQKIS LLREICIKVG IQILLKEYNF DSKHKPTFTE EDILNIFPVV
     KHVNPKATDA FHFFQSGQAK VQQGYLKEGC ELINEALNLF NNVYGAMHVE ICACLRLLAR
     LNYIMGDYSE ALSNQQKAVL MSERIQGVEH PSTVQEYMHL ALYCFANNQV STSLNLLYRA
     RYLMPLVYGE GHPEMALLDS NIGLVLHGVM EYDLSLRFLE NALTINSKYH GVKSLKVALS
     HHLVARVYET KGEFRSALQH EKDGYTIYKN QLGEQHEKTR ESSEYLKYLT QQAVALQRTM
     NEIYKNGSNA NIMPLKFTAP SMTSVLEQLN IINGILFIPL SQKDLEHLKA EVQRRQQLQE
     AIKGAENHEA KTKEPEMSET SDSNINAASV APESSD