CLU_YARLI
ID CLU_YARLI Reviewed; 1181 AA.
AC Q6CE38;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013};
GN OrderedLocusNames=YALI0B18810g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CR382128; CAG83327.1; -; Genomic_DNA.
DR RefSeq; XP_501074.1; XM_501074.1.
DR AlphaFoldDB; Q6CE38; -.
DR SMR; Q6CE38; -.
DR STRING; 4952.CAG83327; -.
DR EnsemblFungi; CAG83327; CAG83327; YALI0_B18810g.
DR GeneID; 2906886; -.
DR KEGG; yli:YALI0B18810g; -.
DR VEuPathDB; FungiDB:YALI0_B18810g; -.
DR HOGENOM; CLU_003256_2_0_1; -.
DR InParanoid; Q6CE38; -.
DR OMA; VSGFYVN; -.
DR Proteomes; UP000001300; Chromosome B.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..1181
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366417"
FT DOMAIN 379..622
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REGION 165..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1181 AA; 130611 MW; FC2DFECC9E03B0C4 CRC64;
MTSEQEEVSI LTLQVTFPDP ELPPLSLTVS PEESVQEIRN YIRDAFVQER CITSFTLNLN
GQPIDGFESL AEIEGLESGA TIELTNAPYN EHEARLHVIR VRELAGFSNN SHAAVGQDAG
MTAFNRTEGI DKTPKDYMQE VVETKAQKEA KAKLKAEQKK AKAAAKAEAL AKNEEVSEDE
ESEPEDDTPM KQSTQVLEEN SPMHGFKLEE SKSLQELFPD RQNLPAPALL SLHLSHWNPP
TQAQQLNGEL LYLQCATLEG ESYQIVAHTN GFYVANSTLG SFDPSPKPLM VKTKAKKQNG
GKKGGKKTET EISYVPITTE NMHHSLYDLL VSLSDKFAKK IASNYAELNA AGMLSVVPPT
NCFLANPWLT KPAGFRRPDM ARNQELLSLK NLEGQDDTRE WSEDLQSLKE LPRETINDRV
VRERHLNKTY FDFTEAAVAG AVQVVHGEIQ PINPSEPEAS HIFLHKGIFY SVGADGSGTY
AEIGGDEAAR VASAKDLQAV QQLVQFDFPE IASLCTTVVD YQGKRIVCQS PVPGIFRQPE
NAPPQVKYGS VEGAEEIASE QEFGDAFKPI AAAFRLKTHT VKDANKEHSL HLASDCKGLA
GTDGRKYLLD LYRLAPVDIA FLDANPSYPH QLALLRFEAV EAYFRHQVRA EIKKQSLDED
ETPKFEVEPF YLNPDAFVLP APKEDEDAVR AASEFVSNTI IPEHVEAVIA GFGTTPIDGQ
QLTQSLHGKG IPMRHLASVI AAAKKSDTSK AQFLAELCEQ EIAVRSAKHL LRNEMAKKGA
NPKYVVAHVM NLLLGSTSKV FDTPAGLLAV SDSVNLSVDE AKAAVAAIAK TRFGYDLDTS
IFAKRPVQLL RELSGKLGLQ FLQKEYEFGA EPFAVADVVN ILPVFKTTTF RSKLVEEALE
AARNSVNTDK DVALQLLRES IPLAEQVYGS VNPELTKVYN TASYLAYEMD EALLAADLGR
RACIMSERCS GIDSVDAILN YLNLSLFEHA IGNYVGALHM IKHAVSVWVT VCGTHLHPDI
ITSLSNAITM LTTLKRWNES RQWLEKTIVI TESVANEKAQ APLRFQLAQT MCHEQQYKEA
TDELRRALKL FNAHYGEDDQ NTKDCAVWLK SLTQAAVSIQ RQKLWEQEQG RLARQAPKPT
ATHQKEAPKK ASKKTKGKGK GKDDKGEKLV AELKKKKAGK R
