CLV2_ARATH
ID CLV2_ARATH Reviewed; 720 AA.
AC O80809; Q84JK9; Q84JT8; Q84JU7; Q84K94; Q84VM8; Q84VM9; Q84VN0; Q9SPE8;
AC Q9SPE9;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 143.
DE RecName: Full=Receptor-like protein CLAVATA2 {ECO:0000312|EMBL:AAF02654.1, ECO:0000312|EMBL:AAF02655.1, ECO:0000312|EMBL:AAF02656.1};
DE AltName: Full=Receptor-like protein 10 {ECO:0000303|PubMed:18434605};
DE Short=AtRLP10 {ECO:0000303|PubMed:18434605};
DE Flags: Precursor;
GN Name=CLV2 {ECO:0000312|EMBL:AAF02654.1, ECO:0000312|EMBL:AAF02655.1,
GN ECO:0000312|EMBL:AAF02656.1}; Synonyms=RLP10 {ECO:0000303|PubMed:18434605};
GN OrderedLocusNames=At1g65380 {ECO:0000312|Araport:AT1G65380};
GN ORFNames=T8F5.16 {ECO:0000312|EMBL:AAC27153.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-80; GLY-87; CYS-110;
RP ILE-125; ILE-134; 139-ALA--VAL-142 DELINS PRO-THR-PHE-MET; GLY-148;
RP ASN-157; ILE-162; ASP-168; ILE-178; LEU-178; ARG-227; 244-ILE--ILE-247
RP DELINS VAL-LEU-ASN-LEU; VAL-285; SER-374; ARG-572 AND THR-649, FUNCTION,
RP AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia, cv. Landsberg erecta, and cv. Wassilewskija;
RX PubMed=10521522; DOI=10.2307/3871087;
RA Jeong S., Trotochaud A.E., Clark S.E.;
RT "The Arabidopsis CLAVATA2 gene encodes a receptor-like protein required for
RT the stability of the CLAVATA1 receptor-like kinase.";
RL Plant Cell 11:1925-1934(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-385, AND VARIANTS SER-80; GLY-87;
RP CYS-110; ILE-125; ILE-134; 139-ALA--VAL-142 DELINS PRO-THR-PHE-MET;
RP THR-139; GLY-148; ASN-157; ILE-162; ASP-168; LEU-178; ILE-178; ILE-207;
RP ARG-227; 244-ILE--ILE-247 DELINS VAL-LEU-ASN-LEU; THR-264; VAL-285; CYS-303
RP AND SER-374.
RC STRAIN=cv. An-2, cv. Bla-1, cv. Bs-1, cv. Bu-0, cv. Chi-1, cv. Co-1,
RC cv. Columbia, cv. Cvi-0, cv. El-0, cv. Fi-0, cv. Gr-3, cv. Ita-0, cv. Jl-3,
RC cv. Kas-1, cv. Lan-0, cv. Landsberg erecta, cv. Lisse-2, cv. Lu-1,
RC cv. Pi-0, cv. Sf-1, and cv. Wassilewskija;
RX PubMed=12663546; DOI=10.1093/genetics/163.3.1083;
RA Shepard K.A., Purugganan M.D.;
RT "Molecular population genetics of the Arabidopsis CLAVATA2 region: the
RT genomic scale of variation and selection in a selfing species.";
RL Genetics 163:1083-1095(2003).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=9729492; DOI=10.1242/dev.125.19.3843;
RA Kayes J.M., Clark S.E.;
RT "CLAVATA2, a regulator of meristem and organ development in Arabidopsis.";
RL Development 125:3843-3851(1998).
RN [7]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=16055633; DOI=10.1105/tpc.105.034009;
RA Fiers M., Golemiec E., Xu J., van der Geest L., Heidstra R., Stiekema W.,
RA Liu C.-M.;
RT "The 14-amino acid CLV3, CLE19, and CLE40 peptides trigger consumption of
RT the root meristem in Arabidopsis through a CLAVATA2-dependent pathway.";
RL Plant Cell 17:2542-2553(2005).
RN [8]
RP GENE FAMILY.
RX PubMed=15955925; DOI=10.1104/pp.104.054452;
RA Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT "Phylogenomic analysis of the receptor-like proteins of rice and
RT Arabidopsis.";
RL Plant Physiol. 138:611-623(2005).
RN [9]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18434605; DOI=10.1104/pp.108.119487;
RA Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT "A genome-wide functional investigation into the roles of receptor-like
RT proteins in Arabidopsis.";
RL Plant Physiol. 147:503-517(2008).
RN [10]
RP FUNCTION, SUBUNIT, AND INTERACTION WITH CLE PEPTIDES.
RX PubMed=20697738; DOI=10.1007/s00425-010-1236-4;
RA Meng L., Feldman L.J.;
RT "CLE14/CLE20 peptides may interact with CLAVATA2/CORYNE receptor-like
RT kinases to irreversibly inhibit cell division in the root meristem of
RT Arabidopsis.";
RL Planta 232:1061-1074(2010).
RN [11]
RP INTERACTION WITH CRN.
RX PubMed=19843317; DOI=10.1111/j.1365-313x.2009.04049.x;
RA Zhu Y., Wang Y., Li R., Song X., Wang Q., Huang S., Jin J.B., Liu C.-M.,
RA Lin J.;
RT "Analysis of interactions among the CLAVATA3 receptors reveals a direct
RT interaction between CLAVATA2 and CORYNE in Arabidopsis.";
RL Plant J. 61:223-233(2010).
RN [12]
RP INTERACTION WITH CRN; CLV3 AND CLE PEPTIDES.
RX PubMed=20626648; DOI=10.1111/j.1365-313x.2010.04295.x;
RA Guo Y., Han L., Hymes M., Denver R., Clark S.E.;
RT "CLAVATA2 forms a distinct CLE-binding receptor complex regulating
RT Arabidopsis stem cell specification.";
RL Plant J. 63:889-900(2010).
RN [13]
RP FUNCTION, SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=19933383; DOI=10.1104/pp.109.149930;
RA Bleckmann A., Weidtkamp-Peters S., Seidel C.A.M., Simon R.;
RT "Stem cell signaling in Arabidopsis requires CRN to localize CLV2 to the
RT plasma membrane.";
RL Plant Physiol. 152:166-176(2010).
RN [14]
RP FUNCTION.
RX PubMed=19897604; DOI=10.1104/pp.109.148197;
RA Wang G., Long Y., Thomma B.P.H.J., de Wit P.J.G.M., Angenent G.C.,
RA Fiers M.;
RT "Functional analyses of the CLAVATA2-like proteins and their domains that
RT contribute to CLAVATA2 specificity.";
RL Plant Physiol. 152:320-331(2010).
RN [15]
RP SUBUNIT.
RX PubMed=20220313; DOI=10.4161/psb.5.3.10790;
RA Zhu Y., Wan Y., Lin J.;
RT "Multiple receptor complexes assembled for transmitting CLV3 signaling in
RT Arabidopsis.";
RL Plant Signal. Behav. 5:300-302(2010).
RN [16]
RP SUBCELLULAR LOCATION.
RX PubMed=21051944; DOI=10.4161/psb.5.11.13359;
RA Guo Y., Clark S.E.;
RT "Membrane distributions of two ligand-binding receptor complexes in the
RT CLAVATA pathway.";
RL Plant Signal. Behav. 5:1442-1445(2010).
RN [17]
RP DISRUPTION PHENOTYPE.
RX PubMed=21705761; DOI=10.1534/genetics.111.130930;
RA Durbak A.R., Tax F.E.;
RT "CLAVATA signaling pathway receptors of Arabidopsis regulate cell
RT proliferation in fruit organ formation as well as in meristems.";
RL Genetics 189:177-194(2011).
RN [18]
RP FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=21265896; DOI=10.1111/j.1365-313x.2010.04433.x;
RA Replogle A., Wang J., Bleckmann A., Hussey R.S., Baum T.J., Sawa S.,
RA Davis E.L., Wang X., Simon R., Mitchum M.G.;
RT "Nematode CLE signaling in Arabidopsis requires CLAVATA2 and CORYNE.";
RL Plant J. 65:430-440(2011).
RN [19]
RP FUNCTION.
RX PubMed=21750229; DOI=10.1104/pp.111.180554;
RA Guo Y., Ni J., Denver R., Wang X., Clark S.E.;
RT "Mechanisms of molecular mimicry of plant CLE peptide ligands by the
RT parasitic nematode Globodera rostochiensis.";
RL Plant Physiol. 157:476-484(2011).
RN [20]
RP REVIEW.
RX PubMed=25064074; DOI=10.1016/j.pbi.2014.07.007;
RA Gust A.A., Felix G.;
RT "Receptor like proteins associate with SOBIR1-type of adaptors to form
RT bimolecular receptor kinases.";
RL Curr. Opin. Plant Biol. 21:104-111(2014).
RN [21]
RP DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, INTERACTION WITH CRN, AND
RP SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=27229734; DOI=10.1093/jxb/erw207;
RA Somssich M., Bleckmann A., Simon R.;
RT "Shared and distinct functions of the pseudokinase CORYNE (CRN) in shoot
RT and root stem cell maintenance of Arabidopsis.";
RL J. Exp. Bot. 67:4901-4915(2016).
RN [22]
RP DISRUPTION PHENOTYPE.
RX PubMed=26990325; DOI=10.1111/nph.13913;
RA Hanemian M., Barlet X., Sorin C., Yadeta K.A., Keller H., Favery B.,
RA Simon R., Thomma B.P., Hartmann C., Crespi M., Marco Y., Tremousaygue D.,
RA Deslandes L.;
RT "Arabidopsis CLAVATA1 and CLAVATA2 receptors contribute to Ralstonia
RT solanacearum pathogenicity through a miR169-dependent pathway.";
RL New Phytol. 211:502-515(2016).
RN [23]
RP FUNCTION, AND INTERACTION WITH CLE14.
RX PubMed=28586647; DOI=10.1016/j.devcel.2017.05.009;
RA Gutierrez-Alanis D., Yong-Villalobos L., Jimenez-Sandoval P.,
RA Alatorre-Cobos F., Oropeza-Aburto A., Mora-Macias J., Sanchez-Rodriguez F.,
RA Cruz-Ramirez A., Herrera-Estrella L.;
RT "Phosphate starvation-dependent iron mobilization induces CLE14 expression
RT to trigger root meristem differentiation through CLV2/PEPR2 signaling.";
RL Dev. Cell 41:555-570(2017).
RN [24]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RC STRAIN=cv. Columbia;
RX PubMed=28607033; DOI=10.15252/embr.201643535;
RA Hazak O., Brandt B., Cattaneo P., Santiago J., Rodriguez-Villalon A.,
RA Hothorn M., Hardtke C.S.;
RT "Perception of root-active CLE peptides requires CORYNE function in the
RT phloem vasculature.";
RL EMBO Rep. 18:1367-1381(2017).
CC -!- FUNCTION: Involved in the perception of CLV3 and CLV3-like (CLE)
CC peptides, that act as extracellular signals regulating meristems
CC maintenance. Required for the sensing of the root CLE peptides (e.g.
CC CLE8, CLE9/CLE10, CLE11, CLE13, CLE14, CLE16, CLE17, CLE18, CLE20,
CC CLE21, CLE25, CLE26, CLE40, CLE41/CLE44 and CLE45), which involves also
CC CRN and leads to root growth regulation, mostly in the phloem and
CC protophloem (PubMed:28607033). Involved in controlling the stem cell
CC population size in shoot and root apical meristems, and during organ
CC development. Promotes the formation of CLV1 multimers. In complex with
CC CRN, perceives secreted CLV3-like effector proteins from plant-
CC parasitic cyst nematodes as ligand mimics of the plant CLE signaling
CC pathway (PubMed:21265896, PubMed:21750229). This recognition is
CC required for proper feeding structure (syncytium) development and
CC ultimately successful nematode infection (PubMed:21265896,
CC PubMed:21750229). CLE14 perception by CLV2/CRN complex triggers root
CC meristem differentiation (PubMed:20697738, PubMed:28586647).
CC {ECO:0000269|PubMed:10521522, ECO:0000269|PubMed:16055633,
CC ECO:0000269|PubMed:19897604, ECO:0000269|PubMed:19933383,
CC ECO:0000269|PubMed:20697738, ECO:0000269|PubMed:21265896,
CC ECO:0000269|PubMed:21750229, ECO:0000269|PubMed:28586647,
CC ECO:0000269|PubMed:28607033, ECO:0000269|PubMed:9729492}.
CC -!- SUBUNIT: Parts of a tetrameric complex made of two CLV2/CRN
CC heterodimers that can interact with CLV3 and CLE peptides. CLV2/CRN
CC heterodimer interacts with CLV1 homodimers. Interacts with CRN; this
CC dimer can interact with BAM3 (PubMed:28607033, PubMed:27229734).
CC Interacts with CLE14 (PubMed:28586647). {ECO:0000269|PubMed:19843317,
CC ECO:0000269|PubMed:19933383, ECO:0000269|PubMed:20220313,
CC ECO:0000269|PubMed:20626648, ECO:0000269|PubMed:20697738,
CC ECO:0000269|PubMed:27229734, ECO:0000269|PubMed:28586647,
CC ECO:0000269|PubMed:28607033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19933383,
CC ECO:0000269|PubMed:21051944, ECO:0000269|PubMed:27229734,
CC ECO:0000269|PubMed:28607033}; Single-pass type I membrane protein
CC {ECO:0000269|PubMed:19933383, ECO:0000269|PubMed:21051944}. Endoplasmic
CC reticulum membrane {ECO:0000269|PubMed:21051944,
CC ECO:0000269|PubMed:27229734, ECO:0000269|PubMed:28607033}; Single-pass
CC type I membrane protein {ECO:0000269|PubMed:21051944}. Note=Requires
CC CRN for export from the endoplasmic reticulum and localization to the
CC plasma membrane. {ECO:0000269|PubMed:19933383,
CC ECO:0000269|PubMed:27229734, ECO:0000269|PubMed:28607033}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in apices (e.g. shoot apical
CC meristem and flower buds), and, to a lower extent, in flowers, leaves,
CC seedlings and siliques. Also expressed in the inner tissues of the
CC proximal root meristem (PubMed:21265896). Expressed throughout the
CC vascular cylinder of root tips (PubMed:28607033).
CC {ECO:0000269|PubMed:10521522, ECO:0000269|PubMed:21265896,
CC ECO:0000269|PubMed:28607033}.
CC -!- DEVELOPMENTAL STAGE: In roots, mostly expressed in the stele and young
CC epidermis cells and, to a weaker extent, in endodermis, cortex and
CC differentiated columella cells. {ECO:0000269|PubMed:27229734}.
CC -!- DISRUPTION PHENOTYPE: Insensitivity to root growth regulation by root
CC CLE peptides (e.g. CLE8, CLE9/CLE10, CLE11, CLE13, CLE14, CLE16, CLE17,
CC CLE18, CLE20, CLE21, CLE25, CLE26, CLE40, CLE41/CLE44 and CLE45)
CC (PubMed:28607033). Impaired interaction with CRN (PubMed:27229734).
CC Stem cell proliferation leading to enlarged shoot and flower meristems,
CC as well as alterations in the development of the gynoecia, flower
CC pedicels, and stamens. Reduced sensitivity to CLV3, CLE19 and CLE40
CC peptides. Ectopic fruit organ initiation after floral meristem
CC termination (PubMed:21705761). Enhanced resistance to nematode
CC infection (PubMed:21265896). Enhanced disease resistance response to
CC the bacterial pathogen Ralstonia solanacearum and to the biotrophic
CC oomycete pathogen Hyaloperonospora arabidopsidis (PubMed:26990325).
CC {ECO:0000269|PubMed:16055633, ECO:0000269|PubMed:21265896,
CC ECO:0000269|PubMed:21705761, ECO:0000269|PubMed:26990325,
CC ECO:0000269|PubMed:27229734, ECO:0000269|PubMed:28607033,
CC ECO:0000269|PubMed:9729492}.
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
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DR EMBL; AF177672; AAF02654.1; -; Genomic_DNA.
DR EMBL; AF177673; AAF02655.1; -; Genomic_DNA.
DR EMBL; AF177674; AAF02656.1; -; Genomic_DNA.
DR EMBL; AC004512; AAC27153.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34367.1; -; Genomic_DNA.
DR EMBL; AY065442; AAL38883.1; -; mRNA.
DR EMBL; AY096537; AAM20187.1; -; mRNA.
DR EMBL; AF528591; AAO43328.1; -; Genomic_DNA.
DR EMBL; AF528592; AAO43329.1; -; Genomic_DNA.
DR EMBL; AF528593; AAO43330.1; -; Genomic_DNA.
DR EMBL; AF528594; AAO43331.1; -; Genomic_DNA.
DR EMBL; AF528595; AAO43332.1; -; Genomic_DNA.
DR EMBL; AF528596; AAO43333.1; -; Genomic_DNA.
DR EMBL; AF528597; AAO43334.1; -; Genomic_DNA.
DR EMBL; AF528598; AAO43335.1; -; Genomic_DNA.
DR EMBL; AF528599; AAO43336.1; -; Genomic_DNA.
DR EMBL; AF528600; AAO43337.1; -; Genomic_DNA.
DR EMBL; AF528601; AAO43338.1; -; Genomic_DNA.
DR EMBL; AF528602; AAO43339.1; -; Genomic_DNA.
DR EMBL; AF528603; AAO43340.1; -; Genomic_DNA.
DR EMBL; AF528604; AAO43341.1; -; Genomic_DNA.
DR EMBL; AF528605; AAO43342.1; -; Genomic_DNA.
DR EMBL; AF528606; AAO43343.1; -; Genomic_DNA.
DR EMBL; AF528607; AAO43344.1; -; Genomic_DNA.
DR EMBL; AF528608; AAO43345.1; -; Genomic_DNA.
DR EMBL; AF528609; AAO43346.1; -; Genomic_DNA.
DR EMBL; AF528610; AAO43347.1; -; Genomic_DNA.
DR EMBL; AF528611; AAO43348.1; -; Genomic_DNA.
DR PIR; T02361; T02361.
DR RefSeq; NP_176717.1; NM_105212.3.
DR AlphaFoldDB; O80809; -.
DR SMR; O80809; -.
DR BioGRID; 28070; 8.
DR IntAct; O80809; 4.
DR STRING; 3702.AT1G65380.1; -.
DR PaxDb; O80809; -.
DR PRIDE; O80809; -.
DR ProteomicsDB; 241069; -.
DR EnsemblPlants; AT1G65380.1; AT1G65380.1; AT1G65380.
DR GeneID; 842849; -.
DR Gramene; AT1G65380.1; AT1G65380.1; AT1G65380.
DR KEGG; ath:AT1G65380; -.
DR Araport; AT1G65380; -.
DR TAIR; locus:2206245; AT1G65380.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_4_1; -.
DR InParanoid; O80809; -.
DR OMA; PHETRRT; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; O80809; -.
DR PRO; PR:O80809; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O80809; baseline and differential.
DR Genevisible; O80809; AT.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISS:TAIR.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0001653; F:peptide receptor activity; IMP:UniProtKB.
DR GO; GO:0010078; P:maintenance of root meristem identity; IMP:UniProtKB.
DR GO; GO:0048507; P:meristem development; IMP:TAIR.
DR GO; GO:0010088; P:phloem development; IMP:UniProtKB.
DR GO; GO:0045595; P:regulation of cell differentiation; IMP:UniProtKB.
DR GO; GO:0010075; P:regulation of meristem growth; IDA:UniProtKB.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 10.
DR PROSITE; PS51450; LRR; 14.
PE 1: Evidence at protein level;
KW Cell membrane; Developmental protein; Disulfide bond;
KW Endoplasmic reticulum; Glycoprotein; Leucine-rich repeat; Membrane;
KW Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..720
FT /note="Receptor-like protein CLAVATA2"
FT /id="PRO_0000401212"
FT TOPO_DOM 26..686
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 687..707
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 708..720
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 96..122
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 124..144
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 146..168
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 170..194
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 195..217
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 219..238
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 239..263
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 264..287
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 288..311
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 314..338
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 339..362
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 364..386
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 388..410
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 411..436
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 438..458
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 459..482
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 484..506
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 547..571
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 573..594
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 595..617
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 619..641
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REGION 26..92
FT /note="N-cap"
FT /evidence="ECO:0000305|PubMed:10521522"
FT REGION 649..682
FT /note="C-cap/acidic domain"
FT /evidence="ECO:0000305|PubMed:10521522"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 270
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 361
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 398
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 446
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 505
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 578
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 614
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 625
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 60..68
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
FT VARIANT 80
FT /note="L -> S (in strain: cv. Chi-1, cv. Wassilewskija)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 87
FT /note="S -> G (in strain: cv. An-2, cv. Bla-1, cv. Bs-1,
FT cv. Bu-0, cv. Chi-1, cv. Co-1, cv. Cvi-0, cv. El-0, cv. Gr-
FT 3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta,
FT cv. Lisse-2, cv. Lu-1, cv. Pi-0, cv. Sf-1, cv.
FT Wassilewskija)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 110
FT /note="S -> C (in strain: cv. Landsberg erecta)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 125
FT /note="T -> I (in strain: cv. An-2, cv. Bla-1, cv. Bs-1,
FT cv. Chi-1, cv. Cvi-0, cv. Lisse-2, cv. Sf-1, cv.
FT Wassilewskija)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 134
FT /note="V -> I (in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv.
FT Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1,
FT cv. Pi-0)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 139..142
FT /note="ATFV -> PTFM (in strain: cv. Bu-0, cv. Co-1, cv. El-
FT 0, cv. Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv.
FT Lu-1, cv. Pi-0)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 139
FT /note="A -> T (in strain: cv. An-2)"
FT /evidence="ECO:0000269|PubMed:12663546"
FT VARIANT 148
FT /note="R -> G (in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv.
FT Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1,
FT cv. Pi-0)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 157
FT /note="D -> N (in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv.
FT Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1,
FT cv. Pi-0)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 162
FT /note="V -> I (in strain: cv. An-2, cv. Bla-1, cv. Bs-1,
FT cv. Chi-1, cv. Cvi-0, cv. Lisse-2, cv. Sf-1, cv.
FT Wassilewskija)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 168
FT /note="N -> D (in strain: cv. An-2, cv. Bla-1, cv. Bs-1,
FT cv. Bu-0, cv. Chi-1, cv. Co-1, cv. Cvi-0, cv. El-0, cv. Gr-
FT 3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta,
FT cv. Lisse-2, cv. Lu-1, cv. Pi-0, cv. Sf-1, cv.
FT Wassilewskija)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 178
FT /note="F -> I (in strain: cv. An-2, cv. Bla-1, cv. Bs-1,
FT cv. Chi-1, cv. Cvi-0, cv. Lisse-2, cv. Sf-1, cv.
FT Wassilewskija)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 178
FT /note="F -> L (in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv.
FT Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta,
FT cv. Lu-1, cv. Pi-0)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 207
FT /note="M -> I (in strain: cv. Ita-0)"
FT /evidence="ECO:0000269|PubMed:12663546"
FT VARIANT 227
FT /note="Q -> R (in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv.
FT Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta,
FT cv. Lu-1, cv. Pi-0)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 244..247
FT /note="ILNI -> VLNL (in strain: cv. Bu-0, cv. Co-1, cv. El-
FT 0, cv. Gr-3, cv. Ita-0, cv. Jl-3, cv. Kas-1, cv. Landsberg
FT erecta, cv. Lu-1, cv. Pi-0)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 264
FT /note="K -> T (in strain: cv. Ita-0)"
FT /evidence="ECO:0000269|PubMed:12663546"
FT VARIANT 285
FT /note="M -> V (in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv.
FT Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1,
FT cv. Pi-0)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 303
FT /note="R -> C (in strain: cv. Ita-0)"
FT /evidence="ECO:0000269|PubMed:12663546"
FT VARIANT 374
FT /note="A -> S (in strain: cv. Bu-0, cv. Co-1, cv. El-0, cv.
FT Gr-3, cv. Jl-3, cv. Kas-1, cv. Landsberg erecta, cv. Lu-1,
FT cv. Pi-0)"
FT /evidence="ECO:0000269|PubMed:10521522,
FT ECO:0000269|PubMed:12663546"
FT VARIANT 572
FT /note="K -> R (in strain: cv. Landsberg erecta)"
FT /evidence="ECO:0000269|PubMed:10521522"
FT VARIANT 649
FT /note="A -> T (in strain: cv. Wassilewskija)"
FT /evidence="ECO:0000269|PubMed:10521522"
SQ SEQUENCE 720 AA; 79228 MW; B5FA831683451831 CRC64;
MIKIADFTLF FFIFVFSPSL PLAQSQLPDL DPQDKASLLI FRVSIHDLNR SLSTWYGSSC
SNWTGLACQN PTGKVLSLTL SGLNLSSQIH PSLCKLSSLQ SLDLSHNNFS GNIPSCFGSL
RNLRTLNLSR NRFVGSIPAT FVSLKELREV VLSENRDLGG VVPHWFGNFS MNLERVDFSF
CSFVGELPES LLYLKSLKYL NLESNNMTGT LRDFQQPLVV LNLASNQFSG TLPCFYASRP
SLSILNIAEN SLVGGLPSCL GSLKELSHLN LSFNGFNYEI SPRLMFSEKL VMLDLSHNGF
SGRLPSRISE TTEKLGLVLL DLSHNSFSGD IPLRITELKS LQALRLSHNL LTGDIPARIG
NLTYLQVIDL SHNALTGSIP LNIVGCFQLL ALMISNNNLS GEIQPELDAL DSLKILDISN
NHISGEIPLT LAGLKSLEIV DISSNNLSGN LNEAITKWSN LKYLSLARNK FSGTLPSWLF
KFDKIQMIDY SSNRFSWFIP DDNLNSTRFK DFQTGGGEGF AEPPGKVEIK ISAAVVAKDE
LSFSYNLLSM VGIDLSDNLL HGEIPEALFR QKNIEYLNLS YNFLEGQLPR LEKLPRLKAL
DLSHNSLSGQ VIGNISAPPG LTLLNLSHNC FSGIITEKEG LGKFPGALAG NPELCVETPG
SKCDPANIDA SQEEIYQNEL VEGPISIWIF CLSAFISFDF GVLGIFCSAR ARSYILQTKA
