ID   CLVS1_PONAB             Reviewed;         354 AA.
AC   Q5RCA6;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Clavesin-1;
DE   AltName: Full=Retinaldehyde-binding protein 1-like 1;
GN   Name=CLVS1; Synonyms=RLBP1L1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for normal morphology of late endosomes and/or
CC       lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate
CC       (PtdIns(3,5)P2) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with clathrin heavy chain and gamma-adaptin.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Early
CC       endosome membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle
CC       {ECO:0000250}.
CC   -!- DOMAIN: The CRAL-TRIO domain is required for targeting to the membrane
CC       and for binding PtdIns(3,5)P2. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Binding to PtdIns(3,5)P2 is not required for
CC       localization. {ECO:0000250}.
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DR   EMBL; CR858372; CAH90601.1; -; mRNA.
DR   RefSeq; NP_001125325.1; NM_001131853.1.
DR   RefSeq; XP_009242108.1; XM_009243833.1.
DR   AlphaFoldDB; Q5RCA6; -.
DR   SMR; Q5RCA6; -.
DR   STRING; 9601.ENSPPYP00000020881; -.
DR   Ensembl; ENSPPYT00000021715; ENSPPYP00000020881; ENSPPYG00000018621.
DR   GeneID; 100172224; -.
DR   KEGG; pon:100172224; -.
DR   CTD; 157807; -.
DR   eggNOG; KOG1471; Eukaryota.
DR   GeneTree; ENSGT00940000159947; -.
DR   HOGENOM; CLU_046597_1_3_1; -.
DR   InParanoid; Q5RCA6; -.
DR   OMA; DSAKMTH; -.
DR   OrthoDB; 1182715at2759; -.
DR   Proteomes; UP000001595; Chromosome 8.
DR   GO; GO:0030136; C:clathrin-coated vesicle; ISS:UniProtKB.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; ISS:UniProtKB.
DR   GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR028634; Clavesin-1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   PANTHER; PTHR10174:SF72; PTHR10174:SF72; 1.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF03765; CRAL_TRIO_N; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Endosome; Golgi apparatus; Lipid-binding; Membrane;
KW   Reference proteome.
FT   CHAIN           1..354
FT                   /note="Clavesin-1"
FT                   /id="PRO_0000297657"
FT   DOMAIN          118..279
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   REGION          333..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   354 AA;  40802 MW;  DC3C9E003FF9FDB2 CRC64;
     MGPVSLLPKY QKLNTWNGDL AKMTHLQAGL SPETIEKARL ELNENPDILH QDIQQVRDMI
     ITRPDIGFLR TDDAFILRFL RARKFHQADA FRLLAQYFQY RQLNLDMFKN FKADDPGIKR
     ALIDGFPGVL ENRDHYGRKI LLLFAANWDQ SRNSFTDILR AILLSLEVLI EDPELQINGF
     ILIIDWSNFS FKQASKLTPS ILKLAIEGLQ DSFPARFGGV HFVNQPWYIH ALYTLIKPFL
     KDKTRKRIFL HGNNLNSLHQ LIHPEFLPSE FGGTLPPYDM GTWARTLLGP DYSDENDYTH
     TSYNAMHVKH TSSNLERECS PKLMKRSQSV VEAGTLKHEE KGENENTQPL LALD