ID   CLZ7_COCLU              Reviewed;         234 AA.
AC   A0A345BJN6;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   07-NOV-2018, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=C2H2-type zinc-finger transcription factor clz7 {ECO:0000303|PubMed:28605916};
DE   AltName: Full=Squalestatin S1 biosynthesis cluster protein clz2 {ECO:0000303|PubMed:28605916};
DE   AltName: Full=Zaragozic acid A biosynthesis cluster protein 7 {ECO:0000303|PubMed:28605916};
GN   Name=clz7 {ECO:0000303|PubMed:28605916};
OS   Cochliobolus lunatus (Filamentous fungus) (Curvularia lunata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Curvularia.
OX   NCBI_TaxID=5503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 74067;
RX   PubMed=28605916; DOI=10.1021/acs.orglett.7b01534;
RA   Liu N., Hung Y.S., Gao S.S., Hang L., Zou Y., Chooi Y.H., Tang Y.;
RT   "Identification and heterologous production of a benzoyl-primed
RT   tricarboxylic acid polyketide intermediate from the zaragozic acid A
RT   biosynthetic pathway.";
RL   Org. Lett. 19:3560-3563(2017).
CC   -!- FUNCTION: Transcription factor that probably regulates the expression
CC       of the gene cluster that mediates the biosynthesis of squalestatin S1
CC       (SQS1, also known as zaragozic acid A), a heavily oxidized fungal
CC       polyketide that offers potent cholesterol lowering activity by
CC       targeting squalene synthase (SS). {ECO:0000305|PubMed:28605916}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; MF806533; AXF50649.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A345BJN6; -.
DR   SMR; A0A345BJN6; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   SUPFAM; SSF57667; SSF57667; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Repeat; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..234
FT                   /note="C2H2-type zinc-finger transcription factor clz7"
FT                   /id="PRO_0000452632"
FT   ZN_FING         159..184
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         191..223
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          45..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..98
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   234 AA;  26102 MW;  09673CDFE0AC7D3F CRC64;
     MERTSKYAEA IDTASQPETV IRASSVTGQQ GHLNSVDMPL VETWRPEGPR ASQQNHILLS
     PEQEVSQSSN TSPTSESDPQ AFLEASEFPQ NQTKTSRVDP VHMEIDDWAA IDQPMADSAQ
     PDFEDWGDLG DLMPEVLPES SGTSSGAATD NGTAADDENR CWDHGCNGKK FLNHSNLVRH
     RRENGSARPK FICPMCGAYF SRSTARNQHL EKKSCNRVRR YSNGRERPRL RVKD