ID   CM11_CONTS              Reviewed;          70 AA.
AC   Q9BH51;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Conotoxin TsMLKM-011;
DE   AltName: Full=Conotoxin TsMLKM-013;
DE   Flags: Precursor;
OS   Conus tessulatus (Tessellate cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Tesselliconus.
OX   NCBI_TaxID=101317;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA   Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT   "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL   Mol. Biol. Evol. 18:120-131(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       3 branch, since 3 residues stand between the fourth and the fifth
CC       cysteine residues.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   EMBL; AF214946; AAG60374.1; -; mRNA.
DR   EMBL; AF215091; AAG60512.1; -; mRNA.
DR   AlphaFoldDB; Q9BH51; -.
DR   ConoServer; 633; Ts3.6 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..54
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000315539"
FT   PEPTIDE         55..70
FT                   /note="Conotoxin TsMLKM-011"
FT                   /id="PRO_0000315540"
FT   DISULFID        56..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..68
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..69
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   70 AA;  8061 MW;  BC6AD9C7263DEB7D CRC64;
     MLKMGVVLFV FLVLFPLATL QLDADQPVER YAENKQLVSP YERRQIILHA LGQRQCCDWQ
     WCDGACDCCA