ID   CM2A2_DICDI             Reviewed;         198 AA.
AC   Q54DB1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Charged multivesicular body protein 2a homolog 2;
DE   AltName: Full=Vacuolar protein-sorting-associated protein 2B;
GN   Name=chmp2a2; Synonyms=vps2B; ORFNames=DDB_G0292400;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III) which is involved in multivesicular
CC       bodies (MVBs) formation and sorting of endosomal cargo proteins into
CC       MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by
CC       invagination and scission from the limiting membrane of the endosome
CC       and are delivered to lysosomes enabling degradation of membrane
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probable core component of the endosomal sorting required for
CC       transport complex III (ESCRT-III). ESCRT-III components are thought to
CC       multimerize to form a flat lattice on the perimeter membrane of the
CC       endosome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; AAFI02000190; EAL61179.1; -; Genomic_DNA.
DR   RefSeq; XP_629585.1; XM_629583.1.
DR   AlphaFoldDB; Q54DB1; -.
DR   SMR; Q54DB1; -.
DR   STRING; 44689.DDB0234176; -.
DR   PaxDb; Q54DB1; -.
DR   EnsemblProtists; EAL61179; EAL61179; DDB_G0292400.
DR   GeneID; 8628645; -.
DR   KEGG; ddi:DDB_G0292400; -.
DR   dictyBase; DDB_G0292400; vps2B.
DR   eggNOG; KOG3230; Eukaryota.
DR   HOGENOM; CLU_069208_1_1_1; -.
DR   InParanoid; Q54DB1; -.
DR   OMA; RYAKKFM; -.
DR   PhylomeDB; Q54DB1; -.
DR   PRO; PR:Q54DB1; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10476; PTHR10476; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..198
FT                   /note="Charged multivesicular body protein 2a homolog 2"
FT                   /id="PRO_0000328592"
FT   COILED          11..42
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   198 AA;  22897 MW;  A34714EB17019A8B CRC64;
     MFLFGKQKTP KEVLRENQRN LNKSMREIDR ERVALQNQEK KIILDIKKMA KQGQMNSAKI
     MAKDLVRTRY HIQKFYEMKT QLQAVSLRIQ TLQSTQAMAE AMKGVTKAMI TMNRQMNLPQ
     FTKIMMEFEQ QSDKMDMKEE MMNDTMDQVM EQDGEEEQSQ EILNQVLDEI GIDLASQLVD
     APTTVGTSVA SKHQVNSG