ID   CM315_CONBU             Reviewed;          76 AA.
AC   P0CY73;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Conotoxin Bu15;
DE   Flags: Precursor;
OS   Conus bullatus (Bubble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Textilia.
OX   NCBI_TaxID=89438;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=21266071; DOI=10.1186/1471-2164-12-60;
RA   Hu H., Bandyopadhyay P.K., Olivera B.M., Yandell M.;
RT   "Characterization of the Conus bullatus genome and its venom-duct
RT   transcriptome.";
RL   BMC Genomics 12:60-60(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21266071}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       1 branch, since 1 residue stands between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CY73; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..43
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000409962"
FT   PEPTIDE         44..76
FT                   /note="Conotoxin Bu15"
FT                   /id="PRO_0000409963"
FT   DISULFID        51..65
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        52..63
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        57..66
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
SQ   SEQUENCE   76 AA;  8626 MW;  1B17531176941C0B CRC64;
     MLKMGVLLFT FLVLFPLATL QLDADQPVER YADNKQDLNP DERMIFLFGG CCRMSSCQPP
     PVCNCCAKQD LNPDER