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CM31_CONLE
ID   CM31_CONLE              Reviewed;          69 AA.
AC   Q5I2P0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Conotoxin Lp3.1 {ECO:0000303|PubMed:17042781};
DE   Flags: Precursor;
OS   Conus leopardus (Leopard cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lithoconus.
OX   NCBI_TaxID=101306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=17042781; DOI=10.1111/j.1742-4658.2006.05493.x;
RA   Han Y.-H., Wang Q., Jiang H., Liu L., Xiao C., Yuan D.-D., Shao X.-X.,
RA   Dai Q.-Y., Cheng J.-S., Chi C.-W.;
RT   "Characterization of novel M-superfamily conotoxins with new disulfide
RT   linkage.";
RL   FEBS J. 273:4972-4982(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:17042781}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:17042781}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC) (Probable).
CC       Classified in the M-1 branch, since 1 residue stands between the fourth
CC       and the fifth cysteine residues. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   EMBL; AY859496; AAW51457.1; -; mRNA.
DR   AlphaFoldDB; Q5I2P0; -.
DR   ConoServer; 1058; Lp3.1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..54
FT                   /evidence="ECO:0000305|PubMed:17042781"
FT                   /id="PRO_0000289871"
FT   PEPTIDE         55..69
FT                   /note="Conotoxin Lp3.1"
FT                   /evidence="ECO:0000305|PubMed:17042781"
FT                   /id="PRO_0000289872"
FT   DISULFID        55..67
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        56..65
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        61..68
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   VARIANT         57
FT                   /note="E -> G (in Lp3.1b)"
SQ   SEQUENCE   69 AA;  7943 MW;  42B49218EEA70867 CRC64;
     MLKMGVLLFI FLVLFPLTTL ELDTDRPVER HAAIKQDLKP QERRGIRLHA PRDECCEPQW
     CDGACDCCS
 
 
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