CM31_CONLE
ID CM31_CONLE Reviewed; 69 AA.
AC Q5I2P0;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 33.
DE RecName: Full=Conotoxin Lp3.1 {ECO:0000303|PubMed:17042781};
DE Flags: Precursor;
OS Conus leopardus (Leopard cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lithoconus.
OX NCBI_TaxID=101306;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=17042781; DOI=10.1111/j.1742-4658.2006.05493.x;
RA Han Y.-H., Wang Q., Jiang H., Liu L., Xiao C., Yuan D.-D., Shao X.-X.,
RA Dai Q.-Y., Cheng J.-S., Chi C.-W.;
RT "Characterization of novel M-superfamily conotoxins with new disulfide
RT linkage.";
RL FEBS J. 273:4972-4982(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:17042781}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:17042781}.
CC -!- DOMAIN: The cysteine framework is III (CC-C-C-CC) (Probable).
CC Classified in the M-1 branch, since 1 residue stands between the fourth
CC and the fifth cysteine residues. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR EMBL; AY859496; AAW51457.1; -; mRNA.
DR AlphaFoldDB; Q5I2P0; -.
DR ConoServer; 1058; Lp3.1 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Secreted; Signal; Toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..54
FT /evidence="ECO:0000305|PubMed:17042781"
FT /id="PRO_0000289871"
FT PEPTIDE 55..69
FT /note="Conotoxin Lp3.1"
FT /evidence="ECO:0000305|PubMed:17042781"
FT /id="PRO_0000289872"
FT DISULFID 55..67
FT /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT DISULFID 56..65
FT /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT DISULFID 61..68
FT /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT VARIANT 57
FT /note="E -> G (in Lp3.1b)"
SQ SEQUENCE 69 AA; 7943 MW; 42B49218EEA70867 CRC64;
MLKMGVLLFI FLVLFPLTTL ELDTDRPVER HAAIKQDLKP QERRGIRLHA PRDECCEPQW
CDGACDCCS