ID   CM31_CONQU              Reviewed;          71 AA.
AC   Q5EHP1;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Conotoxin Qc3.1;
DE   Flags: Precursor;
OS   Conus quercinus (Oak cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=101313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=17042781; DOI=10.1111/j.1742-4658.2006.05493.x;
RA   Han Y.-H., Wang Q., Jiang H., Liu L., Xiao C., Yuan D.-D., Shao X.-X.,
RA   Dai Q.-Y., Cheng J.-S., Chi C.-W.;
RT   "Characterization of novel M-superfamily conotoxins with new disulfide
RT   linkage.";
RL   FEBS J. 273:4972-4982(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       3 branch, since 3 residues stand between the fourth and the fifth
CC       cysteine residues.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   EMBL; AY880685; AAW78562.1; -; mRNA.
DR   AlphaFoldDB; Q5EHP1; -.
DR   SMR; Q5EHP1; -.
DR   ConoServer; 1083; Qc3.1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..54
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000289875"
FT   PEPTIDE         55..71
FT                   /note="Conotoxin Qc3.1"
FT                   /id="PRO_0000289876"
FT   DISULFID        56..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..70
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..71
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  8019 MW;  84E5C4BE8668063E CRC64;
     MLKMGVVLFT FLVLFPLATL QLDADQPAAR YAENKQDLNP NERKEMMLSA LRQRACCDPD
     WCDAGCYDGC C