CM336_CONVE
ID CM336_CONVE Reviewed; 71 AA.
AC Q9BPH6;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Conotoxin VnMLKM-02;
DE Flags: Precursor;
OS Conus ventricosus (Mediterranean cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lautoconus.
OX NCBI_TaxID=117992;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL Mol. Biol. Evol. 18:120-131(2001).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC 3 branch, since 3 residues stand between the fourth and the fifth
CC cysteine residues.
CC -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR EMBL; AF214949; AAG60377.1; -; mRNA.
DR AlphaFoldDB; Q9BPH6; -.
DR SMR; Q9BPH6; -.
DR ConoServer; 636; Vn3.6 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Neurotoxin; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..53
FT /evidence="ECO:0000250"
FT /id="PRO_0000404924"
FT PEPTIDE 56..71
FT /note="Conotoxin VnMLKM-02"
FT /id="PRO_0000404925"
FT DISULFID 56..66
FT /evidence="ECO:0000250"
FT DISULFID 57..70
FT /evidence="ECO:0000250"
FT DISULFID 62..71
FT /evidence="ECO:0000250"
SQ SEQUENCE 71 AA; 8107 MW; 7194A31364123B98 CRC64;
MLKMGVVLFI FLVLFTLATL QLDADQPVER YAENKQLLSP DERRDIILHA LGQRRCCDPD
WCDAGCYDGC C