ID   CM34_CONLT              Reviewed;          70 AA.
AC   Q2I2Q2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Conotoxin Lt3.4;
DE   AltName: Full=Lt3d;
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16908117; DOI=10.1016/j.ygeno.2006.06.014;
RA   Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L.,
RA   Dong M., Chen S., Xu A.;
RT   "Diversity and evolution of conotoxins based on gene expression profiling
RT   of Conus litteratus.";
RL   Genomics 88:809-819(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:16908117}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       1 branch, since 1 residue stands between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   EMBL; DQ345380; ABC74988.1; -; mRNA.
DR   AlphaFoldDB; Q2I2Q2; -.
DR   PRIDE; Q2I2Q2; -.
DR   ConoServer; 1166; LtIIID precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Pyrrolidone carboxylic acid; Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..54
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000315531"
FT   PEPTIDE         55..70
FT                   /note="Conotoxin Lt3.4"
FT                   /id="PRO_0000315532"
FT   MOD_RES         55
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..68
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        57..66
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT   DISULFID        62..69
FT                   /evidence="ECO:0000250|UniProtKB:Q5EHP3"
SQ   SEQUENCE   70 AA;  8440 MW;  6BC997BEFB356213 CRC64;
     MLKMGVLLFT FLVLFPLAMF QLDADQPVER YAENKQDLNR DERMKIMLSA LRQRQCCDWE
     WCDELCSCCW