CM35_CONMR
ID CM35_CONMR Reviewed; 64 AA.
AC P0C1N4;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 29.
DE RecName: Full=Conotoxin Mr3.5;
DE Flags: Precursor;
OS Conus marmoreus (Marble cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX NCBI_TaxID=42752;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=15924437; DOI=10.1021/bi047541b;
RA Corpuz G.P., Jacobsen R.B., Jimenez E.C., Watkins M., Walker C.,
RA Colledge C., Garrett J.E., McDougal O., Li W., Gray W.R., Hillyard D.R.,
RA Rivier J., McIntosh J.M., Cruz L.J., Olivera B.M.;
RT "Definition of the M-conotoxin superfamily: characterization of novel
RT peptides from molluscivorous Conus venoms.";
RL Biochemistry 44:8176-8186(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC 3 branch, since 3 residues stand between the fourth and the fifth
CC cysteine residues.
CC -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C1N4; -.
DR ConoServer; 1468; Mr3.5 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Amidation; Disulfide bond; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..46
FT /evidence="ECO:0000250"
FT /id="PRO_0000246045"
FT PEPTIDE 47..63
FT /note="Conotoxin Mr3.5"
FT /id="PRO_0000246046"
FT MOD_RES 63
FT /note="Cysteine amide"
FT /evidence="ECO:0000250"
FT DISULFID 49..58
FT /evidence="ECO:0000250"
FT DISULFID 50..62
FT /evidence="ECO:0000250"
FT DISULFID 54..63
FT /evidence="ECO:0000250"
SQ SEQUENCE 64 AA; 6907 MW; 2CDD03B1D79B5FEA CRC64;
MSKLGVLLTI CLLLFPLTAL PLDGDQPADQ RAERTQAEKH SLPDPRMGCC PFPCKTSCTT
LCCG