CM35_CONTS
ID CM35_CONTS Reviewed; 72 AA.
AC Q9BPH9;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 47.
DE RecName: Full=Conotoxin TsMLKM-012;
DE Flags: Precursor;
OS Conus tessulatus (Tessellate cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Tesselliconus.
OX NCBI_TaxID=101317;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL Mol. Biol. Evol. 18:120-131(2001).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:11158371}.
CC -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC 1 branch, since 1 residue stands between the fourth and the fifth
CC cysteine residues. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR EMBL; AF214945; AAG60373.1; -; mRNA.
DR AlphaFoldDB; Q9BPH9; -.
DR ConoServer; 632; Ts3.5 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..54
FT /evidence="ECO:0000250"
FT /id="PRO_0000404884"
FT PEPTIDE 55..72
FT /note="Conotoxin TsMLKM-012"
FT /id="PRO_0000404885"
FT DISULFID 56..68
FT /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT DISULFID 57..66
FT /evidence="ECO:0000250|UniProtKB:Q5EHP3"
FT DISULFID 62..69
FT /evidence="ECO:0000250|UniProtKB:Q5EHP3"
SQ SEQUENCE 72 AA; 8149 MW; F8A582CAD89EC2E7 CRC64;
MLKMGVVLFV FLVLFPLATL QLDADQPVER YAENKQLVSP YERRQIILHA LGQRDCCVMP
WCDGACDCCV SS